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The Contribution of Basal Forebrain to Limbic — Motor Integration and the Mediation of Motivation to Action

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The Basal Forebrain

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 295))

Abstract

A major approach of our laboratory has been the use of electrophysiological recording techniques to investigate the effects on the electrical activity of neurons of the basal forebrain of electrical stimulation of the amygdala and hippocampus. As shown in Fig. 1, highly reliable electrophysiological responses to inputs from these two prominent limbic structures are excitation of accumbens neurons and inhibition of subpallidal neurons. Since the ventral striatum receives strong mesolimbic dopamine projections we have also investigated the effects on these electrophysiological responses of dopamine, either applied exogenously to accumbens neurons by micro-iontophoresis, or released endogenously from electrical stimulation of the ventral tegmental area of the midbrain. Dopamine has been shown to modulate the excitatory responses of accumbens neurons to stimulation of the amygdala and hippocampus and, in turn, to influence the electrophysiological responses of subpallidal neurons. The functional implications for limbic-motor integration of the interaction of dopamine inputs to the accumbens with inputs from amygdala and hippocampus have been investigated in complementary behavioral experiments. Before considering the results of our research in more detail some background is needed.

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Authors and Affiliations

  1. Department of Physiology, University of Western Ontario, N6A 5C1, London, Ontario, Canada

    Gordon J. Mogenson

  2. Neuroscience Unit, Ottawa Civic Hospital, Loeb Research Institute, 1053 Carling Avenue, K1Y 4E9, Ottawa, Ontario, Canada

    Charles R. Yang

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  1. Gordon J. Mogenson
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Editors and Affiliations

  1. Loyola University of Chicago, Stritch School of Medicine, Maywood, Illinois, USA

    T. Celeste Napier

  2. College of Veterinary Medicine, Washington State University, Pullman, Washington, USA

    Peter W. Kalivas

  3. Loyola University of Chicago, Stritch School of Medicine, Maywood, Illinois, USA

    Israel Hanin

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© 1991 Plenum Press, New York

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Mogenson, G.J., Yang, C.R. (1991). The Contribution of Basal Forebrain to Limbic — Motor Integration and the Mediation of Motivation to Action. In: Napier, T.C., Kalivas, P.W., Hanin, I. (eds) The Basal Forebrain. Advances in Experimental Medicine and Biology, vol 295. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0145-6_14

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