Abstract
An earlier chapter in this volume (Gordon) has described pathophysiological processes that lead to the generation of extracellular or circulating adenine nucleotides and adenosine. It also summarized the interactions of purines with the endothelial cell surface, reviewing the features of the adenosine transporter and ectonucleotidase enzymes that together constitute a system for regulating the concentrations of purines in plasma; and it outlined the types of purinoceptor (P1, recognizing adenosine; and P2, recognizing ATP or ADP) present on endothelium. In this chapter, we shall discuss further the characterization of the purinoceptors, describing what is currently known of purinoceptor-mediated signal transduction systems in endothelium, and suggesting avenues for future exploration of this topic.
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References
Benham, C.D. and Tsien, R.W. A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle. Nature. 328:275–278, 1987.
Brotherton, A.F.A. and Hoak, J.C. Prostacyclin biosynthesis is limited by deactivation of cyclooxygenase. J. Clin. Invest. 72:1255–1261, 1983.
Burnstock, G. A basis for distinguishing two types of purinergic receptor. In: Cell membrane receptors for drugs and hormones. eds. Bolis, L. and Straub, RW. New York, Raven Press, pp.107–118, 1978.
Burnstock, G. and Kennedy, C. Is there a basis for distinguishing two types of P2-purinocep-tor? Gen. Pharmacol. 16:433–440, 1985.
DeMey, J.G. and Vanhoutte, P.M. Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries. J.Physiol. 316:347–355, 1981.
Drummond, A.H. and Maclntyre, D.E. Protein-kinase C as a bidirectional regulator of cell function. Trends. Pharmacol Sci. 6: 233–234, 1985.
Forsberg, E.J., Feuerstein, G., Shohami, E. and Pollard, M.B. Adenosine triphosphate stimulates inositol phospholipid metabolism and prostacyclin formation in adrenal medullary endothelial cells by means of P2-purinergic receptors. Proc. Natl Acad. Sci U.S.A. 84:5630–5634, 1987.
Goldman, S., Dickinson, E. and Slakey, L. Effect of adenosine on synthesis and release of cyclic AMP by cultured vascular cells from swine. J. Cyc. Nucl. Prot. Phos. Res.. 9:69–78, 1983.
Gordon, J.L. and Martin, W. Endothelium-dependent relaxation of the pig aorta: relationship to stimulation of 86Rb efflux from isolated endothelial cells. Br. J. Pharmacol. 79:537–541, 1983.
Hallam, T.J. and Pearson, J.D. Exogenous ATP raises cytoplasmic free calcium in fura-2 loaded piglet aortic endothelial cells. FEBS Lett. 176:139–143, 1986.
Hallam, T.J., Pearson, J.D. and Needham, L.A. Thrombin-stimulated elevation of human endothelial cell cytoplasmic free calcium concentration causes prostacyclin production. Biochem. J. 251:243–249, 1988.
Halldorsson, H., Kjeld, M. and Thorgeirsson, G. Role of phosphoinositides in the regulation of endothelial prostacyclin production. Arteriosclerosis. 8:147–154, 1988.
Hamilton, K.K. and Sims, P.J. Changes in cytosolic Ca2+ associated with von Willebrand factor release in human endothelial cells exposed to histamine. J. Clin. Invest. 79:600–608, 1987.
Jaffe, E.A., Grulich, J., Weksler, B.B., Hampel, G. and Watanabe, K. Correlation between thrombin-induced prostacyclin production and inositol trisphosphate and cytosolic free calcium levels in cultured human endothelial cells. J. Biol Chem. 262:8557–8565, 1987.
Kai, H., Kanaide, H., Matsumoto, T., Shogakiuchi, Y. and Nakamura, M. Adenosine decreases intracellular free calcium concentrations in cultured vascular smooth muscle cells from rat aorta. FEBS Lett. 212:219–222, 1987.
Kroll, K., Schrader, J. and Mollmann, D. Endothelial activation by adenosine and coronary flow regulation in the guinea pig heart. In: Topics and Perspectives In Adenosine Research, ed. by Gerlach, E. and Becker, BF; Berlin, Springer-Verlag, pp.470–478, 1987.
Kurtz, A. Adenosine stimulates guanylate cyclase activity in vascular smooth muscle cells. J. Biol Chem. 262:6296–6300, 1987.
Lambert, T.L., Kent, R.S. and Whorton, A.R. Bradykinin stimulation of inositol polyphosphate production in porcine aortic endothelial cells. J. Biol Chem. 257:7151–7154, 1986.
Lewis, M.J. and Henderson, A.H. A phorbol ester inhibits the release of endothelial-derived relaxing factor. Eur. J. Pharmacol 137:167–171,1987.
Long, C.J. and Stone, T.W. The release of endothelium-derived relaxant factor is calcium dependent. Blood Vessels. 22:205–208, 1985.
Luckhoff, A. and Busse, R. Increased free calcium in endothelial cells under stimulation with adenine nucleotides. J. Cell. Physiol 126:414–420, 1986.
Martin, W., Cusack, N.J., Carleton, J.S. and Gordon, J.L. Specificity of P2-purinoceptor that mediates endothelium-dependent relaxation of the pig aorta. Eur. J. Pharmacol. 108:295–299, 1985.
Nawroth, P.P., Stern, D.M., Kaplan, K.L. and Nossel, H.L. Prostacyclin production by perturbed bovine aortic endothelial cells in culture. Blood. 64:801–806, 1984.
Needham, L., Cusack, N.J., Pearson, J.D. and Gordon, J.L. Characteristics of the P2 purinoceptor that mediates endothelial prostacyclin production. Eur. J. Pharmacol. 134:199–209, 1987.
Nees, S., Des Rosiers, C. and Bock, M. Adenosine receptors at the coronary endothelium: functional implications. In: Topics and Perspectives In Adenosine Research. eds. Gerlach, E. and Becker, B.F; Berlin, Springer-Verlag, pp.454–467, 1987.
Pearson, J.D., Slakey, L.L. and Gordon, J.L. Stimulation of prostaglandin production through purinoceptors on cultured porcine aortic endothelial cells. Biochem. J. 214:273–276, 1983.
Pirotton, S., Erneux, C. and Boeynaems, J.M. Dual role of GTP-binding proteins in the control of endothelial prostacyclin. Biochem. Biophys. Res. Commun. 147:1113–1120, 1987a.
Pirotton, S., Rapse, E., Demolie, D., Erneux, L. and Boeynaems, J.M. Involvement of inositol 1,4,5-trisphosphate and calcium in the actions of adenine nucleotides on aortic endothelial cells. J. Biol Chem. 262:17461–17467, 1987b.
Rotrosen, G. and Gallin, J.I. Histamine type I receptor occupancy increases endothelial cytoplasmic calcium, reduces F-actin and promotes albumin diffusion across cultured endothelial monolayers. J. Cell Biol 103:2379–2387, 1986.
Schrader, J., Kroll, K., Henrich, M. and Piper, H.M. Coronary and myocardial adenosine receptors. Biomed Biochim. Acta. 46:S421–S426, 1987.
Singer, H.A. and Peach, M.J. Calcium and endothelial mediated vascular smooth muscle relaxation in rabbit aorta. Hypertension. 4:(Suppl.II), 19–25, 1984.
Toothill, V.J., Needham, L., Gordon, J.L. and Pearson, J.D. Desensitization of agonist-stimulated prostacyclin release in human umbilical vein endothelial cells. Eur. J. Pharmacol. 157:189–196, 1988.
Van Coevorden, A. and Boeynaems, J.M. Physiological concentrations of ADP stimulate the release of prostacyclin from bovine aortic endothelial cells. Prostaglandins. 27:615–626, 1984.
Weinheimer, G., Wagner, B. and Osswald, H. Interference of phorbol esters with endothelium-dependent vascular smooth muscle relaxation. Eur. J. Pharmacol. 130:319–322, 1986.
Weksler, B.B., Ley, C.W. and Jaffe, E.A. Stimulation of endothelial prostacyclin production by thrombin, trypsin and the ionophore A23187. J. Clin. Invest. 62:923–930, 1978.
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© 1989 Plenum Press, New York
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Pearson, J.D., Carter, T.D. (1989). Transduction of Purinoceptor-Mediated Endothelial Cell Responses. In: Catravas, J.D., Gillis, C.N., Ryan, U.S. (eds) Vascular Endothelium. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8532-5_19
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DOI: https://doi.org/10.1007/978-1-4684-8532-5_19
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