Vascular Endothelium

Receptors and Transduction Mechanisms

  • John D. Catravas
  • C. Norman Gillis
  • Una S. Ryan

Table of contents

  1. Front Matter
    Pages i-xii
  2. Properties of Endothelial Cell Plasmalemma

  3. Receptors

    1. Front Matter
      Pages 67-67
    2. John L. Gordon
      Pages 69-75
    3. John D. Catravas, Alain B. Legrand, Una S. Ryan, Robert S. Aronstam
      Pages 77-88
    4. Ruth Korth, M. Hirafuji, J. Bidault, B. Canton, F. Russo-Marie, J. Benveniste
      Pages 89-98
    5. Michael E. Maragoudakis
      Pages 111-120
    6. Nicholas A. Kefalides, Zahra Ziaie
      Pages 129-139
    7. Elisabetta Dejana, G. Conforti, A. Zanetti, M. G. Lampugnani, P. C. Marchisio
      Pages 141-147
    8. Jan A. van Mourik, Jacques C. Giltay, Albert E. G. Kr. von dem Borne
      Pages 149-154
  4. Messengers

About this book

Introduction

Beyond their obvious role of a barrier between blood and tissue, vascular endothelial cells are now firmly established as active and essential participants in a host of crucial physiological and pathophysiological functions. Probably the two most important factors responsible for promoting the current knowledge of endothelial functions are 1) observations in the late sixties-early seventies that many non-ventilatory properties of the lung could be attributed to the pulmonary endothelium and 2) the establishment, in the early and mid-seventies of procedures for routine culture of vascular endothelial cells. Many of these endothelial functions require the presence of receptors on the surface of the plasma membrane. There is now evidence for the existence among others of muscarinic, a-and /3-adrenergic, purine, insulin, histamine, bradykinin, lipoprotein, thrombin, paf, fibronectin, vitronectin, interleukin and albumin receptors. For some of these ligands, there is evidence only for the existence of endothelial binding sites. Traditionally, agonist binding must elicit a response for the binding site to be considered a receptor and, in some cases, the nature of the response resulting from the interaction of a substance with the endothelium remains unclear. It is beyond the scope of this introduction to even enumerate the various endothelial homeostatic processes. This monograph contains the proceedings of the Advanced Studies Institute on "Vascular Endothelium: Receptors and Transduction Mechanisms" held in Porto Carras, Greece from June 18-29, 1988.

Keywords

Calcium Plasma Purine cell membrane cells cytokine endothelium lipoprotein pharmacology phosphorylation plasma membrane protein receptor receptors tissue

Editors and affiliations

  • John D. Catravas
    • 1
  • C. Norman Gillis
    • 2
  • Una S. Ryan
    • 3
  1. 1.Medical College of GeorgiaAugustaUSA
  2. 2.Yale University School of MedicineNew HavenUSA
  3. 3.University of Miami School of MedicineMiamiUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4684-8532-5
  • Copyright Information Springer-Verlag US 1989
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-8534-9
  • Online ISBN 978-1-4684-8532-5
  • About this book