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Protein Oxidation and Proteolytic Degradation General Aspects and Relationship to Cataract Formation

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Antioxidants in Therapy and Preventive Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 264))

Abstract

The past few years have seen an explosion of knowledge on the subject of intracellular protein degradation. The view that lysosomes (or rather intra-lysosomal proteases) are primarily responsible for degrading intracellular proteins has now been discredited, and a large number of cytoplasmic proteolytic enzymes have been discovered. It now appears that lysosomes are mostly responsible for the degradation of cellular organelles, whereas most cytoplasmic proteins are degraded by soluble, cytoplasmic proteinases, proteases, and peptidases.1

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Authors and Affiliations

  1. Institute for Toxicology & Department of Biochemistry, The University of Southern California, Los Angeles, California, USA

    Kelvin J. A. Davies

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Editors and Affiliations

  1. Centre National de la Recherche Scientifique, University of Paris, Paris, France

    Ingrid Emerit

  2. Dept. of Physiology Anatomy, University of California, Berkeley, Berkeley, California, 94720, USA

    Lester Packer

  3. Institut Gustave-Roussy, 94800, Villejuif, France

    Christian Auclair

  4. Groupe de Recherche Radicaux Libres, Institut Biomédical des Cordeliers, 15, Rue de l’Ecole de Médecine, 75006, Paris, France

    Ingrid Emerit

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© 1990 Plenum Press, New York

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Davies, K.J.A. (1990). Protein Oxidation and Proteolytic Degradation General Aspects and Relationship to Cataract Formation. In: Emerit, I., Packer, L., Auclair, C. (eds) Antioxidants in Therapy and Preventive Medicine. Advances in Experimental Medicine and Biology, vol 264. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5730-8_77

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  • DOI: https://doi.org/10.1007/978-1-4684-5730-8_77

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