Antioxidants in Therapy and Preventive Medicine

  • Ingrid Emerit
  • Lester Packer
  • Christian Auclair

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Superoxide Dismutase

    1. K. Grabitz, E. Freye, R. Prior, R. Kolvenbach, W. Sandmann
      Pages 13-16
    2. Heinz Redl, Camille Lieners, Soheyl Bahrami, Günther Schlag, Ignaz P. T. van Bebber, R. Jan A. Goris
      Pages 17-27
  3. Copper Complexes and Other Sod Mimicks

    1. Gidon Czapski, Sara Goldstein
      Pages 45-50
    2. Ulrich Weser, Ralf Miesel, Margot Linss
      Pages 51-57
    3. John J. R. Sorenson, Lee S. F. Soderberg, Max L. Baker, John B. Barnett, Louis W. Chang, Hamid Salari et al.
      Pages 69-77
    4. D. M. Miller, D. DeSilva, L. Pickart, S. D. Aust
      Pages 79-84
    5. Amram Samuni, Ahn Min, C. Murali Krishna, James B. Mitchell, Angelo Russo
      Pages 85-92
  4. Antioxidant Vitamins

    1. Lester Packer, Sharon Landvik
      Pages 93-103
    2. Alessandro F. Casini, Emilia Maellaro, Barbara Del Bello, Mario Comporti
      Pages 105-110
    3. Stephan Kaiser, Paolo Di Mascio, Michael E. Murphy, Helmut Sies
      Pages 117-124
    4. Marc Conti, Martine Couturier, Frédérique Lemonnier, Alain Lemonnier
      Pages 125-128
    5. Mariette Gerber, Sylvia Richardson, François Favier, André Crastes De Paulet
      Pages 129-132
    6. L. G. Alcindor, H. Antebi, M. Fadel-Khadra, M-C. Piot, Y. Giudicelli, R. Nordmann
      Pages 133-137

About this book

Introduction

Twenty years ago, the enzyme superoxide dismutase which uses the superoxide radical anion as its specific substrate was reported. With this discovery was born a new scientific field, in which oxygen, necessary for aerobi c 1 ife on thi s planet, had to be cons i dered also in terms of its toxicity and stresses. This stimulated the search for knowledge of active oxygen species in biology and medicine. Superoxide and other reactive oxygen species are now implicated in many disease processes. Major advances have been achieved during these past years with respect to free radical generation and mechanisms of free radical action in causing tissue injury. In parallel, the possibil ity of influencing free radical related disease processes by antioxidant treatment was studied in various in vitro and in vivo systems. This was the unique theme of a conference organized in Paris by the Society for Free Radical Research (December 9-10, 1988) which brought together experts from basic sciences and clinicians in order to evaluate the current status of antioxidant therapy. The conference emphasized fundamental processes in antioxidant action. Among the major topics were superoxide dismutase (SOD) and low molecular weight substances with such activity, called SOD mimics. Other antioxidant enzymes were also considered. Antioxidant vitamins, in particular vitamins E and C, other naturally occurri ng antioxidants and vari ous synthet i c antioxidants were included in the presentations as there is now a rapidly developing series of compounds with potentially interesting clinical applications.

Keywords

antioxidant biology enzyme enzymes preventive medicine research toxicity

Editors and affiliations

  • Ingrid Emerit
    • 1
    • 4
  • Lester Packer
    • 2
  • Christian Auclair
    • 3
  1. 1.Centre National de la Recherche ScientifiqueUniversity of ParisParisFrance
  2. 2.Dept. of Physiology AnatomyUniversity of California, BerkeleyBerkeleyUSA
  3. 3.Institut Gustave-RoussyVillejuifFrance
  4. 4.Groupe de Recherche Radicaux LibresInstitut Biomédical des CordeliersParisFrance

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4684-5730-8
  • Copyright Information Springer-Verlag US 1990
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-5732-2
  • Online ISBN 978-1-4684-5730-8
  • Series Print ISSN 0065-2598
  • About this book