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Molecular Basis of Rhabdovirus Replication

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The Molecular Basis of Viral Replication

Part of the book series: NATO ASI Series ((NSSA,volume 136))

Abstract

A virus was originally classified as a rhabdovirus if it displayed a distinctive elongated morphology (1). Rhabdo means rod-like and all rhabdoviruses have a bacilliform or conical appearance. Over 60 different viruses currently comprise the rhabdovirus group and some members are listed in Table 1 (2). Many of these viruses are transmitted to their plant or vertebrate hosts by insects and, therefore, must be able to successfully infect and replicate in both invertebrate and vertebrate or invertebrate and plant cells. However, transmission by an arthropod vector is not a mandatory requirement for classification as a rhabdovirus since rabies virus is most commonly spread by direct animal contact via the bite of an infected vertebrate. Many viruses in the rhabdovirus group are of interest because as pathogens of livestock (vesicular stomatitis), fish (spring viremia of carp), or plants (lettuce necrotic yellows), they have a significant economic impact. Others, such as rabies virus are feared because they are virulent human pathogens. In humans (and most animals), once a rabies virus infection is established and symptoms appear, there is no effective treatment and death invariably follows due to destruction of the central nervous system. Aside from the obvious importance of rhabdoviruses as pathogens, certain members of the group have generated considerable interest as models for viral replication, glycoprotein biosynthesis, and membrane structure. Vesicular stomatitis virus (VSV) has been particularly useful in this regard because it can be easily propagated to high titers in tissue culture.

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Author information

Authors and Affiliations

  1. University of Virginia, Charlottesville, VA, 22908, USA

    Suzanne U. Emerson & Manfred Schubert

  2. National Institutes of Health, Bethesda, MA, 20892, USA

    Suzanne U. Emerson & Manfred Schubert

Authors
  1. Suzanne U. Emerson
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  2. Manfred Schubert
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Editor information

Editors and Affiliations

  1. The Institute for Virology, University of Rome, Rome, Italy

    R. Perez Bercoff

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© 1987 Plenum Press, New York

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Emerson, S.U., Schubert, M. (1987). Molecular Basis of Rhabdovirus Replication. In: Bercoff, R.P. (eds) The Molecular Basis of Viral Replication. NATO ASI Series, vol 136. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5350-8_11

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  • DOI: https://doi.org/10.1007/978-1-4684-5350-8_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5352-2

  • Online ISBN: 978-1-4684-5350-8

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