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ACTH-Secreting Adenomas

  • Chapter
The Pituitary Adenoma

Abstract

Cushing’s syndrome refers to the clinical and biochemical manifestations due to hypercortisolism of any cause. Hypercortisolism may be due to (1) pharmacological administration of glucocorticoids or adrenocorticotropic hormone (ACTH); (2) excessive, autonomous secretion by an adrenal adenoma or carcinoma; (3) excessive adrenal secretion secondary to increased pituitary secretion of ACTH; or (4) excessive adrenal secretion secondary to the ectopic secretion of ACTH or possibly corticotropin-releasing factor (CRF) by a neoplasm. Cushing’s disease specifically refers to the entity of excess ACTH secretion by the pituitary with resultant bilateral adrenal hyperplasia and hypercortisolism. Because therapeutic modalities for these entities are different, careful endocrinological and radiological evaluations are needed to differentiate between them.

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  1. Department of Medicine, Division of Endocrinology, Tufts-New England Medical Center Hospital, Tufts University School of Medicine, Boston, Massachusetts, 02111, USA

    Mark E. Molitch

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  1. New England Medical Center Hospital, Boston, Massachusetts, USA

    Kalmon D. Post M. D. , Ivor M. D. Jackson M. D.  & Seymour Reichlin M. D., Ph. D. ,  & 

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Molitch, M.E. (1980). ACTH-Secreting Adenomas. In: Post, K.D., Jackson, I.M.D., Reichlin, S. (eds) The Pituitary Adenoma. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3668-6_7

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