Skip to main content
SpringerLink
Log in

Oxygen Supply and Microcirculation of the Brain Cortex

  • Chapter
Oxygen Transport to Tissue VII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 191))

Abstract

The actual oxygen supply of the brain is, as in other organs, dependent on the arterial oxygen capacity, the rate of local blood flow, the diffusion conditions within the organ and the oxygen consumption of the tissue. All these parameters may change under different physiological or pathological conditions and thus influence the O2 supply of the brain. In the following minireview I will focus on the following points.

with support of Deutsche Forschungsgemeinschaft Le 517/1–1

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Baumgärtl, H., and Lübbers, D. W., 1973, Platinum needle electrode for Polarographic measurement of oxygen and hydrogen, in; “Oxygen Supply, Theoretical and Practical Aspects of Oxygen Supply and Microcirculation of Tissue,” M. Kessler, D. F. Bruley, L. C. Clark jr., D. W. Lübbers, I. A. Silver, J. Strauss, eds., Urban & Schwarzenberg, München-Berlin-Wien, pp. 130–136.

    Google Scholar 

  • Betz, E., and Czornai, M., 1978, Action and interaction of perivascular H+, K+, and Ca++ on pial arteries, Pflügers Arch., 374:67–72.

    Article  PubMed  CAS  Google Scholar 

  • Betz, E., Enzenross, H. G., and Vlahow, V., 1973, Interaction of H+ and Ca++ in the regulation of local pial vascular resistance, Pflügers Arch., 343:79–88.

    Article  PubMed  CAS  Google Scholar 

  • Bruley, D. F., Bicher, H. E., Reneau, D. D., and Knisely, M. H., 1971, Dynamics of tissue oxygen supply during circulatory failure, 6th Europ. Conf. on Microcirculation, Aalborg 1970, Karger, Basel, pp. 193–196.

    Google Scholar 

  • Cahn, R., and Leniger-Follert, E., 1983, Effect of isovolemic hemodilution on oxygen supply and electrocorticogram in cat brain during focal ischemia and in normal tissue, Int. J. Microcirc: Clin. Exp., 2:297–313.

    Google Scholar 

  • Clark, L. C. jr., 1956, Monitor and control of blood tissue oxygen tension, Trans. Soc. Art. Int. Organs, 2:41.

    Google Scholar 

  • Erdmann, W., Kunke, St., and Krell, W., 1973, Tissue pO2 and cell function — an experimental study with multimicroelectrodes in the rat brain, in: “Oxygen Supply, Theoretical and Practical Aspects of Oxygen Supply and Microcirculation of Tissue,” M. Kessler, D. F. Bruley, L. C. Clark jr., D. W. Lübbers, I. A. Silver, J. Strauss, eds., Urban & Schwarzenberg, München-Berlin-Wien, pp. 169–174.

    Google Scholar 

  • Gronczewski, J., and Leniger-Follert, E., 1984, Relationship between microflow, local tissue pO2 and extracellular activities of potassium and hydrogen ions in the cat brain during intraarterial infusion of ammonium acetate, Adv. Exp. Med. Biol., 169:291–296.

    Article  PubMed  CAS  Google Scholar 

  • Grote, J., Zimmer, K., and Schubert, R., 1981, Effects of severe arterial hypocapnia on regional blood flow regulation, tissue pO2 and metabolism in the brain cortex of cats, Pflügers Arch., 391: 195–199.

    Article  PubMed  CAS  Google Scholar 

  • Grunewald, W., and Sowa, W., 1977, Capillary structures and O2 supply to tissue. An analysis with a digital diffusion model applied to the skeletal muscle. Rev. Physiol. Biochem. Pharmacol., 77:149–209.

    Article  PubMed  CAS  Google Scholar 

  • Harper, A. M., 1966, Autoregulation of cerebral blood flow: influence of the arterial blood pressure on the blood flow through the cerebral cortex, J. Neurol. Neurosurg. Psychiat., 29:398–403.

    Article  PubMed  CAS  Google Scholar 

  • Katsaros, B., 1965, Der Effekt der Durchtrennung der Sinusnerven auf die Atmung der narkotisierten Katze bei konstant gehaltenem arteriellen Druck und seine Abhängigkeit vom CO2-Druck, Pflügers Arch., 282:179–185.

    Article  CAS  Google Scholar 

  • Kessler, M., Höper, J., and Simon, W., 1974, Methodology and application of multiple ion selective surface electrode (pH, pK, pNa, pCa, pCl) for tissue measurements, Fed. Proc., 33: 279.

    Google Scholar 

  • Kessler, M., 1974, Lebenserhaltende Mechanismen bei Sauerstoffmangel und bei Störungen der Organdurchblutung. Mitteilg. Max-Planck-Ges. 444–463.

    Google Scholar 

  • Kessler, M., Lübbers, D.W., 1966, Aufbau und Anwendungsmöglichkeit verschiedener pO2-Elektroden, Pflügers Arch., 291:82.

    Google Scholar 

  • Krogh, A., 1918/1919, The rate of diffusion of gases through animal tissues with some remarks on the coefficient of invasion. J. Physiol., 52:391–408.

    Google Scholar 

  • Krolicki, L., and Leniger-Follert, E., 1980, Oxygen supply of the brain cortex (rat) during severe hypoglycemia, Pflügers Arch., 387:121–126.

    Article  PubMed  CAS  Google Scholar 

  • Kuschinsky, W., and Wahl, M., 1978, Local chemical and neurogenic regulation of cerebral vascular resistance, Physiol. Rev., 58: 656–689.

    PubMed  CAS  Google Scholar 

  • Kuschinsky, W., Wahl, M., Bosse, O., and Thurau, K., 1972, Perivascular potassium and pH as determinants of local pial arterial diameter in cats. A microapplication study, Circ. Res., 31: 240–247.

    Article  PubMed  CAS  Google Scholar 

  • Leniger-Follert, E., 1984, Mechanisms of regulation of cerebral microflow during bicuculline-induced seizures in anaesthetized cats, J. Cereb. Blood Flow Metab., 4:150–165.

    Article  PubMed  CAS  Google Scholar 

  • Leniger-Follert, E., and Danz, C., 1981, The role of extracellular potassium and hydrogen activities in the brain cortex for regulation of cerebral microcirculation in the cat during generalized seizures and specific sensory stimulation, in; “Progress in Enzyme and Ion-Selective Electrodes,” D. W. Lübbers, H. Acker, R. P. Buck, G. Eisenman, M. Kessler and W. Simon, eds., Springer-Verlag, Berlin-Heidelberg-New York, pp. 100–105.

    Chapter  Google Scholar 

  • Leniger-Follert, E., Gronczewski, J., and Danz, C., 1984, Regulation of microflow in the cat brain during insulin induced hypoglycemia, Adv. Exp. Med. Biol., 169:297–303.

    Article  PubMed  CAS  Google Scholar 

  • Leniger-Follert, E., and Hossmann, K.-A., 1979, Simultaneous measurements of microflow and evoked potentials in the somatomotor cortex of the cat brain during specific sensory activation, Pflügers Arch., 380:85–89.

    Article  PubMed  CAS  Google Scholar 

  • Leniger-Follert, E., and Lübbers, D. W., 1976, Behavior of micro-flow and local pO2 of the brain cortex during and after direct electrical stimulation. A contribution to the problem of metabolic regulation of microcirculation in the brain, Pflügers Arch.,366:39–44.

    Article  PubMed  CAS  Google Scholar 

  • Leniger-Follert, E., Lübbers, D. W., Wrabetz, W., 1975, Regulation of local tissue pO2 of the brain cortex at different arterial 02 pressures, Pflügers Arch., 359:81–95.

    Article  PubMed  CAS  Google Scholar 

  • Lübbers, D. W., 1977, Die Bedeutung des lokalen Gewebesauerstoffdruckes und des pO2-Histogrammes für die Beurteilung der SauerStoffversorgung eines Organes, Prak. Anästhesie. Wiederbelebung und Intensivtherapie, 12:183–193.

    Google Scholar 

  • Lübbers, D. W., 1981, Grundlagen und Bedeutung der lokalen Sauerstoffdruckmessung und des pO2-Histogramms für die Beurteilung der Sauerstoffversorgung der Organe und des Organismus, in: “Messung des Gewebesauerstoffdruckes bei Patienten,” A. M. Ehrly, ed., Gerhard Witzstrock, Baden-Baden-Köln-New York, pp. 11–21.

    Google Scholar 

  • Metzger, H., 1973, pO2 histograms of threedimensional systems with homogeneous and inhomogeneous microcirculation — a digital computer study, in: “Oxygen Supply, Theoretical and Practical Aspects of Oxygen Supply and Microcirculation of Tissue,” M. Kessler, D. F. Bruley, L. C. Clark jr., D. W. Lübbers, I. A. Silver, J. Strauss, eds., Urban & Schwarzen-berg, München-Berlin-Wien, pp. 18–24.

    Google Scholar 

  • Metzger, H., Heuber-Metzger, S., Steinacker, A., and Strüber, J., 1980, Staining pO2 measurement sites in the rat brain cortex and quantitative morphometry of the surrounding capillaries, Pflügers Arch., 388:21–27.

    Article  PubMed  CAS  Google Scholar 

  • Norberg, K., and Siesjö, B. K., 1976, Oxidative metabolism of the cerebral cortex of the rat in severe insulin-induced hypoglycemia, J. Neurochem., 26:345–352.

    Article  PubMed  CAS  Google Scholar 

  • Silver, I. A., 1965, Some observations on the cerebral cortex with an ultramicro, membrane-covered oxygen electrode, Med. Electron. Biol. Engng., 3:377–387.

    Article  CAS  Google Scholar 

  • Smith, R. H., Guilbeau E. J., and Reneau, D. D., 1977, The oxygen tension field within a discrete volume of cerebral cortex, Microvasc. Res., 13:233–240.

    Article  PubMed  CAS  Google Scholar 

  • Thews, G., 1960, Die Sauerstoffdiffusion im Gehirn, Pflügers Arch., 271:197–226.

    Article  CAS  Google Scholar 

  • Wahl, M., Deetjen, P., Thurau, K., Ingvar, D. H., and Lassen, N. A., 1970, Micropuncture evaluation of the importance of perivascular pH for the arteriolar diameter on the brain surface, Pflügers Arch., 316:152–163.

    Article  PubMed  CAS  Google Scholar 

  • Wahl, M., and Kuschinsky, W., 1979, Unimportance of perivascular H+ and K+ activities for the adjustment of pial artery diameter during changes in arterial blood flow pressure in cats, Pflügers Arch., 382:203–208.

    Article  PubMed  CAS  Google Scholar 

  • Whalen, W. F., Canfield, R., and Nair, P., 1970, Effects of breathing O2 or O2 + CO2 and of the injection of neurohumors on the PO2 of cat cerebral cortex, Stroke, 1:194–200.

    Article  PubMed  CAS  Google Scholar 

  • Whalen, W. F., Riley, J., and Nair, P., 1967, A microelectrode for measuring intracellular PO2, J. Appl. Physiol., 23:798–801.

    PubMed  CAS  Google Scholar 

  • Wiernsperger, N., Gygax, P., and Meier-Ruge, W., 1978, Changes in cerebrocortical pO2 distribution, rCBF and EEG during hypovolemic shock, Adv. Exp. Med. Biol., 94:605–610.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Max-Planck-Institut für Systemphysiologie, Rheinlanddamm 201, 4600, Dortmund 1, Germany

    Elfriede Leniger-Follert

Authors
  1. Elfriede Leniger-Follert
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Nijmegen, Nijmegen, The Netherlands

    F. Kreuzer  & Z. Turek  & 

  2. University of Alabama at Birmingham, Birmingham, Alabama, USA

    S. M. Cain

  3. Northwestern University, Evanston, Illinois, USA

    T. K. Goldstick

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Plenum Press, New York

About this chapter

Cite this chapter

Leniger-Follert, E. (1985). Oxygen Supply and Microcirculation of the Brain Cortex. In: Kreuzer, F., Cain, S.M., Turek, Z., Goldstick, T.K. (eds) Oxygen Transport to Tissue VII. Advances in Experimental Medicine and Biology, vol 191. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3291-6_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-3291-6_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3293-0

  • Online ISBN: 978-1-4684-3291-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation