Summary
Local tissue oxygen pressure (Po 2)was recorded with a platinum multiwire surface electrode at adjacent sites of the cat cortex under steady-state conditions and with different arterial oxygen supply. SimultaneouslyPo 2in the sinus sagittalis was continuously recorded through the vascular wall in some experiments. Under normoxic and steady-state conditions localPo 2values varied between 0 Torr and almost arterial levels of 90 Torr. This was in accordance with the assumption of a diffusive transport of oxygen in tissue. With increased arterial oxygen supply local tissuePo 2reacted quite differently at adjacent sites. Linear increases in local tissuePo 2as compared to arterialPo 2as well as constant levels, very small increases and even small decreases were recorded. Constancy or small changes, respectively, of localPo 2(=localPo 2regulation) may be caused by changes in microflow, but changes in oxygen consumption cannot be excluded completely. The regulation of localPo 2could be abolished by adding CO2 to the gas mixture or by producing tissue anoxia. With severely reduced arterial oxygen supply local tissuePo 2dropped down to hypoxic or anoxic levels at all sites measured.
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Betz, E.: Spontane Schwankungen der Gehirndurchblutung in Narkose und im Wachzustand. Ärztl. Forsch.21, 88–89 (1967)
Bicher, H. I.: Autoregulation of oxygen supply to brain tissue. In: Oxygen Transport to Tissue, Vol. 37 A, eds. H. I. Bicher and D. F. Bruley, pp. 215–222. Advanc. exp. Med. Biol. New York: Plenum Press 1973
Bicher, H. I.: Brain oxygen autoregulation: A protective reflex to hypoxia? Microvasc. Res.8, 291–313 (1974)
Bicher, H. I., Bruley, D., Reneau, D. D., Knisely, M.: Regulatory mechanisms of brain oxygen supply. In: Oxygen supply. Theoretical and practical aspects of oxygen supply and microcirculation of tissue, eds. M. Kessler, D. F. Bruley, L. C. Clark, Jr., D. W. Lübbers, I. A. Silver, and J. Strauss, pp. 180–185. München-Berlin-Wien: Urban & Schwarzenberg 1973
Bruley, D. F., Reneau, D. D., Bicher, H. I., Knisely, M. H.: Modeling cerebral tissue oxygenation with autoregulation. In: Oxygen supply. Theoretical and practical aspects of oxygen supply and microcirculation, eds. M. Kessler, D. F. Bruley, L. C. Clark, Jr., D. W. Lübbers, I. A. Silver, and J. Strauss, pp. 32–39. München-Berlin-Wien: Urban & Schwarzenberg 1973
Clark, L. C., Jr.: Monitor and control of blood tissue oxygen tension. Trans. Soc. Art. Int. Organs2, 41 (1956)
Erdmann, W., Kunke, St., Krell, W.: TissuePo 2and cell function—An experimental study with multimicroelectrodes in the rat brain. In: Oxygen supply. Theoretical and practical aspects of oxygen supply and microcirculation of tissue, eds. M. Kessler, D. F. Bruley, L. C. Clark, Jr., D. W. Lübbers, I. A. Silver, and J. Strauss, pp. 169–174. München-Berlin-Wien: Urban & Schwarzenberg 1973
Grunewald, W.: Digitale Simulation eines räumlichen Diffusionsmodells der O2-Versorgung biologischer Gewebe. Pflügers Arch.309, 266–284 (1969)
Ingvar, D. H., Lübbers, D. W., Siesjö, B.: Measurement of oxygen tension on the surface of the cerebral cortex of the cat during hyperoxia and hypoxia. Acta physiol. scand.48, 373–381 (1960)
Kessler, M., Lübbers, D. W.: Aufbau und Anwendungsmöglichkeiten verschiedenerPo 2-Elektroden.Pflügers Arch. ges. Physiol.291, R32 (1966)
Kety, S. S., Schmidt, C. F.: The effects of altered arterial tensions of carbon dioxide and oxygen on cerebral blood flow and cerebral oxygen consumption of normal young men. J. clin. Invest.27, 484–492 (1948)
Knaust, Kr.: Sauerstoffversorgung des hämoglobinfrei perfundierten Meerschweinchengehirns bei Normo- und Hypothermie. Diss., Marburg 1967
Leniger-Follert, E., Lübbers, D. W.: On continuous transparietal measurement of arterial and venousPo 2.Pflügers Arch.347, R42 (1974)
Leniger-Follert, E., Lübbers, D. W.: Interdependence of capillary flow and regional blood flow of the brain. Stroke4, 327–328 (1973)
Lübbers, D. W.: Kritische Sauerstoffversorgung und Mikrozirkulation. In: Marburger Jahrbuch 1966/67, ed. C. G. Wendt, pp. 305–319. Marburg: Elwert 1967
Lübbers, D. W.: The oxygen pressure field in the brain and its significance for the normal and critical oxygen supply of the brain. In: Oxygen transport in blood and tissue, eds. D. W. Lübbers, U. C. Luft, G. Thews, and E. Witzleb, pp. 67–92. Berlin-Heidelberg-New York: Springer 1968
Lübbers, D. W., Baumgärtl, H., Fabel, H., Huch, A., Kessler, M., Kunze, K., Riemann, H., Seiler, D., Schuchhardt, S.: Principle and construction of various platinum electrodes. In: Oxygen pressure recording in gases, fluids and tissues, ed. F. Kreuzer. Progr. Resp. Res.3, 136–146 (1969)
Lübbers, D. W., Stosseck, K.: Quantitative Bestimmung der lokalen Durchblutung durch elektrochemisch im Gewebe erzeugten Wasserstoff. Naturwissenschaften57, 311–312 (1970)
Metzger, H., Erdmann, W., Thews, G.: Effect of short periods of hypoxia, hyperoxia, and hypercapnia on brain O2 supply. J. appl. Physiol.31, 751–759 (1971)
Nair, P., Whalen, W. J., Buerk, D.:Po 2of cat cerebral cortex: Response to breathing N2 and 100% O2. Microvasc. Res.9, 158–165 (1975)
Opitz, E., Thews, G.: Einfluß von Frequenz und Faserdicke auf die Sauerstoffversorgung des menschlichen Herzmuskels. Arch. Kreisl.-Forsch.18, 137–163 (1952)
Schaertlin, C. E.: Polarographische Messung der Sauerstoffspannung im Hirnblut bei Hypoxie. Helv. physiol. pharmacol. Acta19, 255–262 (1961)
Severinghaus, J. W.: Discussion in Alfred Benzon Symposium on the working brain, Copenhagen May 26–30, 1974 (in press)
Silver, I. A.: Brain oxygen tension and cellular activity. In: Oxygen supply. Theoretical and practica laspects of oxygen supply and microcirculation of tissue, eds. M. Kessler, D. F. Bruley, L. C. Clark, Jr., D. W. Lübbers, I. A. Silver, and J. Strauss, pp. 186–188. München-Berlin-Wien: Urban & Schwarzenberg 1973
Stosseck, K., Lübbers, D. W., Cottin, N.: Determination of local blood flow (microflow) by electrochemically generated hydrogen. Construction and application of the measuring probe. Pflügers Arch.348, 225–238 (1974)
Whalen, W. J., Ganfield, R., Nair, P.: Effects of breathing O2 or O2+CO2 and of the injection of neurohumors on thePo 2of cat cerebral cortex. Stroke1, 194–200 (1970)
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Parts of the results were reported at the 3rd Tbilisi Symposium on Brain Blood Supply, June 5–7, 1974, and at the Alfred Benzon Symposium VIII on The Working Brain, Copenhagen, May 26–30, 1974.
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Leniger-Follert, E., Lübbers, D.W. & Wrabetz, W. Regulation of local tissuePo 2of the brain cortex at different arterial O2 pressures. Pflugers Arch. 359, 81–95 (1975). https://doi.org/10.1007/BF00581279
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DOI: https://doi.org/10.1007/BF00581279