Abstract
Natural glucocorticosteroids and synthetic antiinflammatory steroids (“steroids” for brevity) are widely used in the treatment of allergic and inflammatory conditions however the mechanism of their immunosuppressive and anti-inflammatory actions remains unknown. Steroids do not significantly affect antibody production in man but seem to prevent macrophages from responding to lymphokines that are elaborated by T lymphocytes (Claman, 1975). Steroids potentiate stimulatory effects of catecholamines and PGE1 on accumulation of cyclic-AMP in human leucocytes and lymphocytes (Parker et al. 1973; Mendelsohn et al., 1973), and if so, this might result in a decreased liberation of eosinophil chemo-tactic factor of anaphylaxis (ECF-A), slow reacting substance of anaphylaxis (SRS-A) and histamine from appropriate cells (Kaliner and Austen, 1975). Indeed, steroids depress the release of histamine from anaphylactic guinea pig lungs (Gryglewski et al., 1975) and from other tissues (Kurihara and Shibata, 1975). Early reports that steroids impair the formation of kinins has not been confirmed (Eisen et al., 1968).
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ANDERSON, A.D., BROCKLEHURST, W.E., and WILLIS, A.L., 1971, Evidence for the role of lysosomes in the formation of prostaglandins during carrageenin-induced inflammation in rat. Pharmacol. Res. Commun. 3: 13.
BONILLA, C.A., and DUPONT, D., 1976, Fatty acid and prostaglandin composition of left ventricular myocardium from dexamethasone-treated dogs with severe low output syndrom. Prostaglandins 11: 935.
CHANG, J., LEWIS, G.P., and PIPER, P.D., 1975, The effects of anti-inflammatory steroids on levels of prostaglandins in adipose tissue in vitro.Proc. Br. Pharmacol. Soc. 17–19 December, p. 342P.
CLAMAN, H.N., 1975, How corticosteroids work. J. Allergy Clin. Immunol. 55: 145.
EISEN, V., GREENBAUM, L., and LEWIS, G.P., 1968, Kinins and anti-inflammatory steroids. Br. 3. Pharmac. 34; 169.
FERREIRA, S.H., MONCADA, S., and VANE J.R., 1971, Indometacin and aspirin abolish prostaglandin release from the spleen. Nature New Biol. 231: 237.
FLOMAN, Y., FLOMAN, N., and ZOR, U., 1976, Inhibition of prostaglandin E release by anti-inflammatory steroids. Prostaglandins 11: 591.
FLOWER, R.J., 1974, Drugs which inhibit prostaglandin biosynthesis. Pharmac. Rev. 26: 33.
FLOWER, R., GRYGLEWSKI, R., HERBACZYńSKA-CEDRO, K., and VANE, J.R., 1972, Effects of anti-inflammatory drugs on prostaglandin biosynthesis. Nature New Biology 238: 104.
FLOWER, R.J., and BLACKWELL, G.J., 1976, The importance of phospholipase A2 in prostaglandin biosynthesis. Biochem. Pharmacol. 25: 285.
FLOWER, R.J., HARVEY, E.A., MONCADA, S., NIJKAMP, F., and VANE, J.R., A communication during the Meeting of Br. Pharmacol. Soc. 1–2 April, 1976, in Chelsea College. Proc. Br. Pharmacol. Soc. p.47.
GREAVES, M.W., KINGSTON, W.P., and PRETTY K., 1975, Action of a series of non-steroid and steroid antiinflammatory drugs on prostaglandin synthesis by microsomal fraction of rat skin. Brit. J. Pharmacol. 53: 470P.
GREAVES, M.W., and MCDONALD-GIBSON W., 1972a, Inhibition of prostaglandin biosynthesis by corticosteroids. Br. Med. J. 1: 83.
GREAVES, M.W., and MCDONALD-GIBSON, W., 1972b, Prostaglandin biosynthesis by human skin and its inhibition by corticosteroids. Br. J. Pharmac. 46: 172.
GREESON, T.P., LEVARI, N.E., and FREEDMAN, R.I.., 1973, Corticosteroid-induced vasoconstriction studied by xenon-133 clereance. J. Invest. Dermatol. 61: 242.
GRODZIńSKA, L., PANCZENKO, B., and GRYGLEWSKI, R.J., 1976, Release of prostaglandin-like material from perfused mesenteric blood vessels of rabbits. O. Pharm. Pharmac. 28: 40.
GRYGLEWSKI, R.J., 1976, Steroid hormones anti-inflammatory steroids and prostaglandins. Pharmacol. Res. Commun. 8: 337.
GRYGLEWSKI, R.J., and KORBUT, R., 1975, Prostaglandin feedback mechanism limits vasoconstrictor action of norepinephrine in perfused rabbit ear. Experientia 31: 89.
GRYGLEWSKI, R.J., and KORBUT, R., 1976, Bioassay of histamine in the presence of prostaglandins. Br. J. Pharmac. 56: 39.
GRYGLEWSKI, R.J., PANCZENKO, B., KORBUT, R., GRODZIńSKA, L., and OCETKIEWICZ, A., 1975, Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pig. Prostaglandins 10: 343.
GRYGLEWSKI, R.J., and OCETKIEWICZ, A., 1974, A release of prostaglandins may be responsible for acute tolerance to norepinephrine infusions. Prostaglandins 8: 31.
HERBACZYńSKA-CEDRO, K., and STASZEWSKA-BARCZAK, J., 1976, Adrenocortical hormones and the release of prostaglandin-like substances, in the symposium on prostaglandins, Second Congress of Hungarian Pharmacological Society (J. Knoll and K. Keleman, eds.), p. 157, Akademiai Kiado, Budapest.
KALINER, M., and AUSTEN, K.F., 1975, Immunologic release of chemical mediators from human tissues in: Annual Review of Pharmacology, (H.W. Elliot, R. George and R. Okum, eds.), p. 177. Annual Review Inc. California.
KANTROWITZ, F., ROBINSON, D.R., McQUIRE, M.B., and LEVINE, L., 1975, Corticosteroids inhibit prostaglandin production by rheumatoid synovia. Nature 258: 737.
KURIHARA, N., and SHIBATA, K., 1975, Effects of corticosteroids on the release of mediators in anaphylaxis of sensitized guinea pig tissues. Japan J. Pharmacol. 25: 181.
LEGRANDE, C.E., SORENSON, K., and BUHRLEY, L.E., 1975, Mechanism and interactions in testicular steroidogenesis and prostaglandin synthesis. J. Steroidal. Biochem. 6: 1081.
LEWIS, G.P., and PIPER, P.J., 1975, Inhibition of release of prostaglandins as an explanation of some of the actions of anti-inflammatory corticosteroids. Nature 254: 308.
LEWIS, G.P., and PIPER, P.J., 1976a, Inhibition of prostaglandin release by anti-inflammatory steroids, in: Advances in Prostaglandin and Thromboxane Research, Vol. 1 (B. Samuelsson and R. Paoletti, eds.), p. 121, Raven Press, New York.
LEWIS, G.P., and PIPER, P.J., 1976b, The action of corticosteroids on the prostaglandin system, in: The role of prostaglandins in inflammation. Proceedings of a workshop held during the VIIIth European Rheumatology Congress, Helsinki 1975, p. 148. (G. P. Lewis, ed.), Hans Huber Pub. Bern-Stuttgard-Vienna.
McINTRIE, F.C., 1973, Histamine release by antigen-antibody reactions, in: Histamine and Antihistamines, Vol. 1 (M. Schachter, ed.), p. 45, Pergamon Press, Oxford-New York-Toronto.
MENDELSOHN, J., MUTIER, M.M., and BOONE, R.F., 1973, Enhanced effects of prostaglandin E1 and dibutyryl cyclic AMP on human lymphocytes in the presence of Cortisol. J. Clin. Invest. 52: 2129.
PALMER, M.A., PIPER, P.J., and VANE, J.R., 1973, Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea pig lungs. Br. O. Pharmac. 49: 226.
PAOLETTI, R., and PUGLISI, L., 1973, Lipid metabolism, in: The Prostaglandins, Vol. 1 (P.W. Ramwell, ed.), p. 317, Plenum Press, New York-London.
PARKER, C.W., HUBER, M.G., and BAUMANN, M.L., 1973, Alterations in cyclic AMP metabolism in human bronchial asthma. III. Leukocyte and lymphocyte responses to steroids. J. Clin. Invest. 52: 1342.
PATRONO, C., CIABATTONI, G., GRECO, F., and GROSSI-BELLONI, D., 1976, Comparative evaluation of the inhibitory effects of aspirin-like drugs on prostaglandin production by human platelets and synovial tissue, in: Advances in Prostaglandin and Thromboxane Research, Vol. 1 (B. Samuelsson and R. Paoletti, eds.), p.125, Raven Press, New York.
PIPER, P.J., and VANE, J.R., 1969, Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs. Nature 233: 29.
PIPER, P.J., and VANE, J.R., 1971, The release of prostaglandins from lung and other tissues. N.Y. Acad. Sci. 180: 363.
RAHMAN, Y.E., VERHAGEN, J., and VAN DER WIEL, D.F.M., 1970, Evidence of a membrane-bound phospholipase A in rat liver lysosomes. Biochim. Biophys. Res. Commun. 38: 670.
SMITH, A.D., and WINKLER, H., 1968, Lysosomal phospho-lipases A. and A2 of bovine adrenal medulla. Biochern. J. 108: 867.
SMITH, J.B., and WILLIS, A.L., 1971, Aspirin selectively inhibits prostaglandin production in human platelets. Nature New Biol. 231: 235.
SVENSSON, J., HAMBERG, M., and SAMUELSSON, B., 1975, Prostaglandin endoperoxides IX. Characterization of rabbit aorta contracting substance (RCS) from guinea pig lung and human platelets. Acta Physiol. Scand. 94: 222.
TASHJIAN, A.H., VOELKEL, E.F., McDONOUGH, J., and LEVINE, L., 1975, Hydrocortisone inhibits prostaglandin production by mouse fibrosarcoma cells. Nature 258: 739.
VANE, J.R., 1971, Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biol. 231: 232.
VARGAFTIG, B.B., 1974, Search for common mechanisms underlying the various effects of putative inflammatory mediators, in: The Prostaglandins, Vol. 2. (P.W. Ramwell, ed.), p. 205. Plenum Press, New York -London.
WEISSMANN, G., 1973, Effect of corticosteroids on the stability and fusion of biomembranes, in: Asthma (A. Austen and L.M. Lichtenstein, eds.), p. 221. Academic Press, New York and London.
WEISSMANN, G., 1964, Labilization and stabilization of lysosomes. Fed. Proc. 23: 1038.
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Gryglewski, R.D., Korbut, R., Dembińska-Kieć, A. (1977). Influence of Anti-Inflammatory Steroids on Prostaglandin and Thromboxane Release from Tissues. In: Berti, F., Samuelsson, B., Velo, G.P. (eds) Prostaglandins and Thromboxanes. NATO Advanced Study Institutes Series, vol 13. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2778-3_25
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