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Hemopexin, The Heme-Binding Serum β-Glycoprotein

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Structure and Function of Plasma Proteins

Abstract

Hemopexin, a heme-binding serum protein, was first described by Neale et al in 1958.1 The high carbohydrate content and immunoelectrophoretic identity of this macromolecule led to its designation by Schultze et al. 2 as β1B-glycoprotein. The name “hemopexin”, given by Grabar et al.,3 reflects the ability of the protein to bind heme† in an equimolar ratio.4,5 The other serum protein which binds metalloporphyrins, although with lower affinity,6 is albumin. In several of the following sections, the two proteins will be compared.

From the Department of Biochemistry, Scripps Clinic and Research Foundation, and the Division of Pediatric Hematology, Department of Pediatrics, University of California at San Diego, La Jolla, Ca. 92037.

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  1. Scripps Clinic and Research Foundation, La Jolla, California, 92037, USA

    Ursula Muller-Eberhard & Ham Heng Liem

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  1. Ursula Muller-Eberhard
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  1. Clinical Research Centre, Watford Road, Harrow, Middlesex, UK

    A. C. Allison

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Muller-Eberhard, U., Liem, H.H. (1974). Hemopexin, The Heme-Binding Serum β-Glycoprotein. In: Allison, A.C. (eds) Structure and Function of Plasma Proteins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2676-2_2

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  • DOI: https://doi.org/10.1007/978-1-4684-2676-2_2

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