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Immunoengineering: Prospects for Correction of Age-Related Immunodeficiency States

  • Chapter
Immunology and Aging

Part of the book series: Comprehensive Immunology ((COMIMUN,volume 1))

Abstract

The term immunoengineering in the context used here refers to procedures that may serve to ameliorate the immunologic abnormalities associated with aging. Such amelioration would be important for both theoretical and practical reasons. From the standpoint of theory, it has been repeatedly emphasized that the only valid test of an aging hypothesis requires significant extension of the life span of long-lived strains of animals, including extension of the longest-lived or tenth decile survivorship (Walford, 1969, 1974). Considered in these terms, life span cannot be extended merely by eliminating specific diseases (Strehler, 1975). A major extension of longest-lived survivorship by measures that can only be interpreted immunologically would constitute formal proof of the immunologic theory of aging, at least in terms of pathogenesis (Walford, 1974).

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Authors and Affiliations

  1. Department of Pathology, UCLA School of Medicine, Los Angeles, California, USA

    Roy L. Walford, Patricia J. Meredith & Kay E. Cheney

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  1. Roy L. Walford
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  2. Patricia J. Meredith
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  3. Kay E. Cheney
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Editors and Affiliations

  1. Baltimore City Hospitals, Baltimore, Maryland, USA

    Takashi Makinodan

  2. Veterans Administration Wadsworth Hospital Center, USA

    Takashi Makinodan

  3. University of California, Los Angeles, USA

    Takashi Makinodan

  4. Sidney Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA

    Edmond Yunis

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© 1977 Plenum Publishing Corporation

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Walford, R.L., Meredith, P.J., Cheney, K.E. (1977). Immunoengineering: Prospects for Correction of Age-Related Immunodeficiency States. In: Makinodan, T., Yunis, E. (eds) Immunology and Aging. Comprehensive Immunology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2541-3_13

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  • DOI: https://doi.org/10.1007/978-1-4684-2541-3_13

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