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Brain Cholinergic Systems and the Pathogenesis of Affective Disorders

  • Chapter
Central Cholinergic Mechanisms and Adaptive Dysfunctions

Abstract

Extreme and debilitating fluctuations in mood have long been thought to involve chemical imbalances in the central nervous system. The role of catecholamines in the affective disorders has been emphasized since the pioneering work by Schildkraut and Kety (1967) and others, who noted that drugs which elevate mood and which are effective in the treatment of depression facilitate catecholaminergic transmission in the brain, and conversely, that drugs which may produce depression and that are used in the treatment of manic behavior tend to antagonize the synaptic actions of dopamine and norepinephrine. Measurements of catecholamine metabolites in the urine and cerebrospinal fluid of manic and depressed patients have also produced some evidence consistent with the view that depression is associated with reduced catecholaminergic synaptic transmission (Schildkraut, 1973; Schildkraut and Kety, 1967).

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Author information

Authors and Affiliations

  1. Psychiatry Service, San Diego Veterans Administration Medical Center, San Diego, California, 12161, USA

    David S. Janowsky, Samuel Craig Risch & Leighton Y. Huey

  2. Department of Psychiatry, University of California, San Diego, La Jolla, California, 92093, USA

    David S. Janowsky, Samuel Craig Risch, Lewis L. Judd & Leighton Y. Huey

  3. Department of Medicine San Diego Veterans Administration Medical Center, University of California, San Diego, La Jolla, California, 92093, USA

    Donal C. Parker

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  1. David S. Janowsky
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  2. Samuel Craig Risch
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  3. Lewis L. Judd
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  4. Leighton Y. Huey
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Editor information

Editors and Affiliations

  1. Southern Illinois University School of Medicine, Springfield, Illinois, USA

    Man Mohan Singh

  2. University of Reading, Reading, UK

    David M. Warburton

  3. Texas College of Osteopathic Medicine, Fort Worth, Texas, USA

    Harbans Lal

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Janowsky, D.S., Risch, S.C., Judd, L.L., Huey, L.Y., Parker, D.C. (1985). Brain Cholinergic Systems and the Pathogenesis of Affective Disorders. In: Singh, M.M., Warburton, D.M., Lal, H. (eds) Central Cholinergic Mechanisms and Adaptive Dysfunctions. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1218-5_10

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  • DOI: https://doi.org/10.1007/978-1-4684-1218-5_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1220-8

  • Online ISBN: 978-1-4684-1218-5

  • eBook Packages: Springer Book Archive

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