Central Cholinergic Mechanisms and Adaptive Dysfunctions

  • Man Mohan Singh
  • David M. Warburton
  • Harbans Lal

Table of contents

  1. Front Matter
    Pages i-x
  2. David M. Warburton, Keith Wesnes
    Pages 1-35
  3. Susan E. Robinson
    Pages 37-61
  4. Albert Wauquier, G. H. C. Clincke
    Pages 63-103
  5. David G. Spencer Jr., Harbans Lal
    Pages 141-159
  6. Robert Bell, Kenneth Brown
    Pages 161-192
  7. Alexander G. Karczmar, Daniel L. Richardson
    Pages 193-221
  8. David M. Warburton, Keith Wesnes
    Pages 223-245
  9. David S. Janowsky, Samuel Craig Risch, Lewis L. Judd, Leighton Y. Huey, Donal C. Parker
    Pages 309-333
  10. Back Matter
    Pages 399-408

About this book

Introduction

Although serious interest in studying the role of central cho­ linergic processes in psychopathology is just beginning to emerge, experimental literature on the part played by cholinergic mechanisms in brain behavior. reiations is quite extensive. During the past thirty years, cholinergic research has contributed significantly to the characterization and differentiation of adaptive mechanisms in­ volved in input selection, perception, cortical, autonomic and behav­ ioral activation, learning, memory, and inhibitory control of behav­ ioral outputs. To say that dysfunction of one or more of these mech­ anisms may be at the root of neuropsychiatric illnesses such as schiz­ ophrenia would be stating the obvious. This book examines the part cholinergic processes might play in dysfunctions of the adaptive processes involved in higher brain func­ tions and their significance for the pathogenesis, classification, etiology, and treatment of psychopathological conditions. In a series of wide ranging reviews of the available information, the subject is discussed from a variety of perspectives, using data derived from both experimental and clinical research. The purpose is not so much to determine whether cholinergic excess or deficiency is causal in this or that neuropsychiatric syndrome, but rather to try to understand the disease mechanisms in terms of adaptive processes in which cholinergic systems seem to play an important part.

Keywords

behavior brain classification clinical research dementia etiology memory neuropathology pathogenesis pathology perception psychopathology research schizophrenia treatment

Editors and affiliations

  • Man Mohan Singh
    • 1
  • David M. Warburton
    • 2
  • Harbans Lal
    • 3
  1. 1.Southern Illinois University School of MedicineSpringfieldUSA
  2. 2.University of ReadingReadingUK
  3. 3.Texas College of Osteopathic MedicineFort WorthUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4684-1218-5
  • Copyright Information Springer-Verlag US 1985
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-1220-8
  • Online ISBN 978-1-4684-1218-5
  • About this book