Central Cholinergic Mechanisms and Adaptive Dysfunctions

1. Front Matter

   Pages i-x

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2. Historical Overview of Research on Cholinergic Systems and Behavior

   • David M. Warburton, Keith Wesnes

   Pages 1-35

3. Cholinergic Pathways in the Brain

   • Susan E. Robinson

   Pages 37-61

4. Functions of Central Cholinergic Systems in the Brain-Behavior

   • Albert Wauquier, G. H. C. Clincke

   Pages 63-103

5. New Aspects on the Functional Role of Acetylcholine in the Basal Ganglia System

   • Jørgen Scheel-Krüger

   Pages 105-139

6. Central Cholinergic Involvement in Learning and Memory

   • David G. Spencer Jr., Harbans Lal

   Pages 141-159

7. Cholinergic Mechanisms in Aggressive Behavior

   • Robert Bell, Kenneth Brown

   Pages 161-192

8. Cholinergic Mechanisms, Schizophrenia, and Neuropsychiatric Adaptive Dysfunctions

   • Alexander G. Karczmar, Daniel L. Richardson

   Pages 193-221

9. Acetylcholine and Attentional Disorder

   • David M. Warburton, Keith Wesnes

   Pages 223-245

10. Pharmacology of Central Cholinergic Mechanisms and Schizophrenic Disorders

    • Man Mohan Singh, Stanley R. Kay

    Pages 247-308

11. Brain Cholinergic Systems and the Pathogenesis of Affective Disorders

    • David S. Janowsky, Samuel Craig Risch, Lewis L. Judd, Leighton Y. Huey, Donal C. Parker

    Pages 309-333

12. Cholinergic Neuropsychopharmacology and Neuropathology of Dementias

    • Konrad C. Retz, Harbans Lal

    Pages 335-352

13. Cholinergic Mechanisms, Adaptive Brain Processes and Psychopathology

    • Man Mohan Singh

    Pages 353-397

14. Back Matter

    Pages 399-408

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Although serious interest in studying the role of central cho­ linergic processes in psychopathology is just beginning to emerge, experimental literature on the part played by cholinergic mechanisms in brain behavior. reiations is quite extensive. During the past thirty years, cholinergic research has contributed significantly to the characterization and differentiation of adaptive mechanisms in­ volved in input selection, perception, cortical, autonomic and behav­ ioral activation, learning, memory, and inhibitory control of behav­ ioral outputs. To say that dysfunction of one or more of these mech­ anisms may be at the root of neuropsychiatric illnesses such as schiz­ ophrenia would be stating the obvious. This book examines the part cholinergic processes might play in dysfunctions of the adaptive processes involved in higher brain func­ tions and their significance for the pathogenesis, classification, etiology, and treatment of psychopathological conditions. In a series of wide ranging reviews of the available information, the subject is discussed from a variety of perspectives, using data derived from both experimental and clinical research. The purpose is not so much to determine whether cholinergic excess or deficiency is causal in this or that neuropsychiatric syndrome, but rather to try to understand the disease mechanisms in terms of adaptive processes in which cholinergic systems seem to play an important part.

• behavior
• brain
• classification
• clinical research
• dementia
• etiology
• memory
• neuropathology
• pathogenesis
• pathology
• perception
• psychopathology
• research
• schizophrenia
• treatment

• Southern Illinois University School of Medicine, Springfield, USA

  Man Mohan Singh

• University of Reading, Reading, UK

  David M. Warburton

• Texas College of Osteopathic Medicine, Fort Worth, USA

  Harbans Lal

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