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Penetration of Antimicrobial Agents into Cerebrospinal Fluid

Pharmacokinetic and Clinical Aspects

  • Chapter
Neurobiology of Cerebrospinal Fluid 1

Abstract

Most often, bacterial and fungal infections in the central nervous system are life-threatening infections that require acute antimicrobial treatment. These disorders are rarely self-limited, secondary to the limited ability of the immune reactions of the cerebrospinal fluid (CSF) to eliminate pathogenic organisms. Even in the presence of meningeal inflammation, the CSF contains less than 0.1% of the number of circulating immunocompetent leukocytes found in peripheral blood, and scant quantities of immunoglobulins. Thus, the rapid achievement of therapeutic CSF concentrations of appropriate antibiotics is imperative for the successful treatment of meningitis.

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Authors and Affiliations

  1. Department of Infectious Diseases, East Hospital, University of Gothenburg, S-41685, Gothenburg, Sweden

    Ragnar Norrby M.D. Ph.D.

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  1. Ragnar Norrby M.D. Ph.D.
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  1. Division of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104, USA

    James H. Wood M.D. (Consultant) (Consultant)

  2. Pediatric Oncology Branch, National Cancer Institute National National Institutes of Health, Bethesda, Maryland, 20205, USA

    James H. Wood M.D. (Consultant) (Consultant)

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© 1980 Plenum Press, New York

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Norrby, R. (1980). Penetration of Antimicrobial Agents into Cerebrospinal Fluid. In: Wood, J.H. (eds) Neurobiology of Cerebrospinal Fluid 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1039-6_32

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  • DOI: https://doi.org/10.1007/978-1-4684-1039-6_32

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