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Studies on the Mechanism of Action of Tityustoxin

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Animal, Plant, and Microbial Toxins

Abstract

The contraction of the isolated rat ileum produced by purified scorpion toxin (tityustoxin or TsTX) was explained by the release of acetylchohne and probably substance P, whereas the relaxation of the atropine-treated rat duodenum depended on an adrenergic mechanism (Cunha-Melo et al., 1973). As our understanding of the toxin actions remains incomplete, it was decided to reinvestigate the subject. Preliminary reports have been presented elsewhere (Calixto et al., 1971; Calixto and Freire-Maia, 1972; Freire-Maia et al., 1973; Freire-Maia et al., 1974; Futuro-Neto et al., 1974).

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© 1976 Plenum Press, New York

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Freire-Maia, L. et al. (1976). Studies on the Mechanism of Action of Tityustoxin. In: Ohsaka, A., Hayashi, K., Sawai, Y., Murata, R., Funatsu, M., Tamiya, N. (eds) Animal, Plant, and Microbial Toxins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0889-8_24

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  • DOI: https://doi.org/10.1007/978-1-4684-0889-8_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-0891-1

  • Online ISBN: 978-1-4684-0889-8

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