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Clinical Aspects of Gastrointestinal Mucus

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Mucus in Health and Disease—II

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 144))

Abstract

In his Croonian Lecture of 1964,1 Sir Howard Florey attributed three significant functions to gastrointestinal mucus: protection of the underlying mucosa from chemical and physical injury, lubrication of the mucosal surface to facilitate passage of luminal ingredients and the removal of parasites by binding and entrapment. In re-reading Florey’s seminal contribution to this field, one is struck by the little our understanding of the fundamental functions of mucus has expanded in the intervening years. To a great extent even the three “Floreyian” roles for this “slimey secretion” remain articles of faith, buttressed at best, by indirect and circumstantial pieces of evidence which lack convincing bite. If I can use a phrase turned by a Torontonian philosopher, Marshall McLuhan, it may be as true of mucus as of modern communication that “the medium is the message”. If so, we will probably never understand function fully until the structural and organizational complexities of mucus are unravelled.

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References

  1. H. Florey, Mucin and the protection of the body, Proc. Roy. Soc. London, Series B, 143: 147 (1955).

    Article  CAS  Google Scholar 

  2. J. Schrager, and M. D. G. Oates, The isolation and composition of the major glycoprotein from human gastric aspirates, Gut 12: 559 (1971).

    Article  PubMed  CAS  Google Scholar 

  3. D. Snary, and A. Allen, Studies on gastric mucoproteins. The isolation and characterization of the mucoprotein of the water-soluble mucus from pig cardiac gastric mucosa, Biochem. J. 123: 845 (1971).

    PubMed  CAS  Google Scholar 

  4. J. Forstner, N. Taichman, V. Kalnins, and G. Forstner, Intestinal goblet cell mucus: isolation and identification by immunofluorescence of a goblet cell glycoprotein, J. Cell. Sci. 12: 585 (1973).

    PubMed  CAS  Google Scholar 

  5. I. Jabbal, D. I. C. Kells, G. Forstner, and J. Forstner. Human intestinal goblet cell mucin, Can. J. Biochem. 54: 707 (1976).

    Article  PubMed  CAS  Google Scholar 

  6. T. Marshall, and A. Allen, The isolation and characterization of the high-molecular-weight glycoprotein from pig colonic mucus, Biochem. J. 173: 569 (1978).

    PubMed  CAS  Google Scholar 

  7. V. L. N. Murty, F. Downs, and W. Pigman, Rat colonic, mucus glycoprotein, Carb. Res. 6: 139 (1978).

    Google Scholar 

  8. B. L. Slomiany, V. Murty, and A. Slomiany, Isolation and characterization of oligosaccharides from rat colonic mucus glycoprotein, J. Biol. Chem. 255: 9719 (1980).

    PubMed  CAS  Google Scholar 

  9. B. L. Slomiany, and K. Meyer, Oligosaccharides produced by acetolysis of blood group A (A+H) sulfated glycoproteins from hog gastric mucin, J. Biol. Chem. 248: 2290 (1973).

    PubMed  CAS  Google Scholar 

  10. W. Newman, and E. A. Kabat, Immunological studies on blood groups. Structures and immunochemical properties of nine oligosaccharides for β-active blood group substances of horse gastric mucosae, Arch. Biochem. Biophys. 172: 535 (1976).

    Article  CAS  Google Scholar 

  11. V. Derevitskaya, N. Arbatsky, and N. Kochetkov, The structure of carbohydrate chains of blood group substance, Eur. J. Biochem. 86: 423 (1978).

    Article  PubMed  CAS  Google Scholar 

  12. M. D. G. Oates, A. Rosbottom, and J. Schrager, Further investigations into the structure of human gastric mucin. Carb. Res. 34: 115 (1974).

    Article  CAS  Google Scholar 

  13. D. Carlson, Structures and immunochemical properties of oligosaccharides isolated from pig submaxillary mucins, J. Biol. Chem. 243: 616 (1968).

    PubMed  CAS  Google Scholar 

  14. T. Beyer, J. Rearick, J. Paulson, J. P. Prieels, J. E. Sadler, and R. L. Hill, Biosynthesis of mammalian glycoproteins. Glycosylation pathways in the synthesis of the nonreducing terminal sequence, J. Biol. Chem. 254: 12531 (1979).

    PubMed  CAS  Google Scholar 

  15. J. F. Forstner, I. Jabbal, R. Qureshi, D. Kells, and G. G. Forstner, The role of disulphide bonds in human intestinal mucin, Biochem. J. 181: 725 (1979).

    PubMed  CAS  Google Scholar 

  16. S. J. List, B. P. Findlay, G. G. Forstner, and J. F. Forstner, Enhancement of the viscosity of mucin by serum albumin, Biochem. J. 175: 565 (1978).

    PubMed  CAS  Google Scholar 

  17. J. R. Clamp, and M. Gough, Study of the oligosaccharide units from mucus glycoproteins of meconium from normal infants and from cases of cystic fibrosis with meconium ileus, J. Path. 126: 197 (1978).

    Article  Google Scholar 

  18. A. Allen, M. Mantle, and J. Pearson, The structure and properties of mucus glycoproteins, in: “Proceedings of the 8th International Congress on Cystic Fibrosis,” J. M. Sturgess, ed., Imperial Press Ltd, Toronto (1980).

    Google Scholar 

  19. J. Bara, A. Paul-Gardias, F. Loisillier, and P. Burtin, Isolation of a sulfated glycopeptide antigen from human gastric tumors, Int. J. Cancer 21: 133 (1978).

    Article  PubMed  CAS  Google Scholar 

  20. D. V. Gold, and F. Miller, A Mucoprotein with colon-specific determinants, Tissue Antigens 11: 362 (1978).

    Article  PubMed  CAS  Google Scholar 

  21. R. Qureshi, G. G. Forstner, and J. F. Forstner, Radioimmunoassay of human intestinal goblet cell mucin, J. Clin. Invest. 64: 1149 (1979).

    Article  PubMed  CAS  Google Scholar 

  22. N. G. Heatley, Mucosubstance as a barrier to diffusion, Gastroent. 37: 313 (1959).

    CAS  Google Scholar 

  23. J. Machin, Osmotic gradients across snail epidermis. Evidence for a water barrier, Science 183: 759 (1974).

    Article  PubMed  CAS  Google Scholar 

  24. V. Negus, Mucus, Proc. Roy. Soc. Med. 60: 75 (1967).

    PubMed  CAS  Google Scholar 

  25. B. E. Lukie, Studies of mucus permeability, Mod. Prob. Paed. 19: 46 (1977).

    CAS  Google Scholar 

  26. F. Nimmerfall, and J. Rosenthaler, Significance of the goblet-cell mucin layer, the outermost luminal barrier to passage through the gut wall, Biochem. Biophys. Res. Comm. 94: 960 (1980).

    Article  PubMed  CAS  Google Scholar 

  27. J. Nakamura, K. Shima, T. Kimura, S. Muranishi, and H. Sezaki, Intestinal mucus in the absorption of quinine and water-soluble dyes from the rat small intestine, Chem. Pharm. Bull. 26: 857 (1978).

    Article  PubMed  CAS  Google Scholar 

  28. M. P. Braybrooks, B. W. Barry, and E. T. Abbs, The effect of mucin on the bioavailability of tetracycline from the gastrointestinal tract, in vivo, in vitro correlations, J. Pharm. Pharmacol. Commun. 27: 508 (1975).

    CAS  Google Scholar 

  29. I. W. Kellaway, and C. Marriot, The influence of mucin on the bioavailability of tetracycline, J. Pharm. Pharmacol. Commun. 27: 281 (1975).

    CAS  Google Scholar 

  30. E. G. Lovering, and D. B. Black, Drug permeation through membranes III: Effect of pH and various substances on permeation of phenylbutazone through everted rat intestine and poly-dimethyl-siloxane, J. Pharmac. Sci. 63: 671 (1974).

    Article  CAS  Google Scholar 

  31. J. F. Forstner, and G. G. Forstner, Calcium binding to intestinal goblet cell mucin, Biochim. Biophys. Acta 386: 283 (1975).

    PubMed  CAS  Google Scholar 

  32. J. F. Forstner, and G. G. Forstner, Effects of calcium on intestinal mucin. Implications for cystic fibrosis, Pediat. Res. 10: 609 (1976).

    Article  PubMed  CAS  Google Scholar 

  33. J. R. Coleman, and L. B. Young, Metal binding by intestinal mucus, in: “Scanning Electron Microscopy II”, A. M. F. O’Hare, ed., S. E. M. Inc., Ill. (1979).

    Google Scholar 

  34. A. Albert, and C. W. Rees, Avidity of the tetracyclines for the cations of metals, Nature 177: 433 (1956).

    Article  PubMed  CAS  Google Scholar 

  35. P. W. Kent, and A. Allen, The biosynthesis of intestinal mucins, Biochem. J. 106: 645 (1968).

    PubMed  CAS  Google Scholar 

  36. B. E. Lukie, and G. G. Forstner, Synthesis of intestinal glycoproteins. Inhibition of (I– 14C) glucosamine incorporation by sodium salicylate in vitro, Biochim. Biophys. Acta 283: 380 (1972).

    Article  Google Scholar 

  37. B. E. Lukie, and G. G. Forstner. Synthesis of intestinal glycoproteins. Inhibition of (I–14C) glucosamine incorporation by phenylbutazone in vitro, Biochim. Biophys. Acta 338: 345 (1974).

    Article  CAS  Google Scholar 

  38. R. Menguy, and A. E. Thompson, Regulation of secretion of mucus from the gastric antrum, Ann. N.Y. Acad. Sci. 140: 797 (1967).

    Article  PubMed  CAS  Google Scholar 

  39. W. Domschke, S. Domschke, M, Classen, and L. Demling, Some properties of mucus in patients with gastric ulcer. Effects of treatment with carbonoxolone. Scand. J. Gastroent. 7: 647 (1972).

    Article  PubMed  CAS  Google Scholar 

  40. J. S. Shillingford, W. E. Lindup, and D. V. Parke, The effects of carbonoxolone on the biosynthesis of gastric glycoproteins in the rat and ferret, Biochem. Soc. Trans. 2: 1104 (1974).

    CAS  Google Scholar 

  41. J. P. Bolton, D. Palmer, and M. Cohen, Stimulation of mucus and non parietal cell secretion by E2 prostaglandins, Am. J. Dig. Dis. 23: 359 (1978).

    Article  PubMed  CAS  Google Scholar 

  42. A. Robert, Antisecretory antiulcer cytoprotective and diarrheogenic properties of the prostaglandins, Adv. Prostag. Thrombox. Res. 2: 507 (1976).

    CAS  Google Scholar 

  43. W. Domschke, S. Domschke, J. Hagel, L. Demling, and D. N. Croft, Gastric epithelial cell turnover, mucus production and healing of gastric ulcers with carbonoxolone, Gut 18: 817 (1977).

    Article  PubMed  CAS  Google Scholar 

  44. J. E. Nozamis, and A. Robert, Gastric mucus may mediate the cytoprotective effect of prostaglandins, Gastroent. 78: 1228 (1980).

    Google Scholar 

  45. M. Guslandi, M. Cambielli, L. Bierti, and A. Tittobello, Relapse of duodenal ulceration after cimetidine treatment, Brit. Med. J. 1: 718 (1978). (Letter).

    Article  PubMed  CAS  Google Scholar 

  46. R. S. Cathcart, C. T. Fitts, J. McAlhany, and S. S. Spicer, Histochemical changes in gastric mucosubstances with acute and chronic ulcer disease, Surgery 180: 1 (1974).

    Google Scholar 

  47. N. B. Roberts, and W. H. Taylor, The inactivation by carbon-oxylone of individual human pepsinogens and pepsins, Clin. Sci. Mol. Med. 45: 213 (1973).

    PubMed  CAS  Google Scholar 

  48. Y. Mikuni-Takagaki, and K. Hotta, Characterization of peptic inhibitory activity associated with sulphated glycoproteins isolated from gastric mucosa, Biochim. Biophys. Acta 584: 288, (1979).

    Article  CAS  Google Scholar 

  49. M. I. Filipe, and C. Fenger, Histochemical characteristics of mucins in the small intestine. A comparative study of normal mucosa, benign epithelial tumours and carcinoma, Histochem. J. 11: 277 (1979).

    Article  PubMed  CAS  Google Scholar 

  50. Y. S. Kim, A. Bella, Jr., J. S. Whitehead, R. Isaacs, and L. Remer, Studies on the binding of amylopectin sulfate with gastric mucin, Gastroent. 69: 138 (1975).

    CAS  Google Scholar 

  51. M. N. Guentzel, L. H. Field, E. R. Eubanks, and L. J. Barry, Use of fluorescent antibody in studies of immunity to cholera, Inf. Immun. 15: 539 (1977).

    CAS  Google Scholar 

  52. H. U. Bertschinger, J. W. Moon, and S. C. Whipp, Association of E. coli with intestinal epithelium, Inf. Immun. 5: 595 (1972).

    CAS  Google Scholar 

  53. R. C. Williams, and R. J. Gibbons, Inhibition of streptococcal attachment to receptors on human buccal epithelial cells by antigenically similar salivary glycoproteins, Inf. Immun. 11: 711 (1975).

    CAS  Google Scholar 

  54. D. R. Strombeck, and D. Harrold, Binding of cholera toxin to mucins and inhibition by gastric mucin. Inf. Immun. 10: 1266 (1974).

    CAS  Google Scholar 

  55. R. di Girolamo, J. Liston, and J, Matches, Ionic binding: the mechanism of viral uptake by shellfish mucus, Appl. Environ. Microbiol. 33: 19 (1977).

    PubMed  Google Scholar 

  56. D. C. Savage, Factors involved in colonization of the gut epithelial surface, Am. J. Clin. Nutr. 31: 131 (1978).

    Google Scholar 

  57. L. E. Hoskins, and E. T. Boulding, Degradation of blood group antigens in human colon ecosystems, J. Clin. Invest. 57: 63 (1976).

    Article  PubMed  CAS  Google Scholar 

  58. L. E. Hoskins, and E. T. Boulding, Degradation of blood group antigens in human colon ecosystems. J. Clin. Invest. 57: 74 (1976).

    Article  PubMed  CAS  Google Scholar 

  59. R. Winsnes, T. Midtveldt, and A. Trippestad, Rat intestinal glycoprotein lowering bactericidal activity of serum on 32P-labelled E. Coli, Acta Path. Microbiol. Scand. Sect. C, 84: 77 (1976).

    CAS  Google Scholar 

  60. H. R. P. Miller, and Y. Nawa, Immune regulation of intestinal goblet cell differentiation, Nouv. Rev. Fr. Hematol. 21: 31 (1979).

    PubMed  CAS  Google Scholar 

  61. H. R. P. Miller, and Y. Nawa, Nippostrongylus brasiliensis: intestinal goblet cell response in adoptively immunized rats, Exper. Parasit. 47: 81 (1979).

    Article  CAS  Google Scholar 

  62. W. A. Walker, and M. Wu, Stimulation by immune complexes of mucus release from goblet cell of the rat small intestine, Science 97: 370 (1977).

    Article  Google Scholar 

  63. A. D. Befus, N. Johnston, and J. Bienemstock, Nippostrongylus brasielensis: mast cells and histamine levels in tissues of infected and normal rats. Exper. Parasit. 48: 1 (1979).

    Article  CAS  Google Scholar 

  64. J. Forstner, B. Maxwell, and N. Roomi, Intestinal secretions of mucin in chronically reserpinized rats. Am. J. Physiol. (In press).

    Google Scholar 

  65. B. J. Underdown, I. C. Roberts-Thomson, R. F. Anders, and G. F. Mitchell, Giardiasis in mice: studies on the characteristics of chronic infection in C3H/He mice, J. Immunol. 126: 669 (1981).

    PubMed  CAS  Google Scholar 

  66. S. Coles, Regulation of the secretory cycles of mucous and serous cells in the human bronchial gland, in: “Mucus in Health and Disease,” M. Elstein and D.V. Parke, eds., Plenum Press, London (1977).

    Google Scholar 

  67. J. T. Gallagher, P. W. Kent, R. Phipps, and P. Richardson, Influence of pilocarpine and ammonia vapour on the secretion and structure of cat tracheal mucins, in: “Mucus in Health and Disease,” M. Elstein and D.V. Parke, eds., Plenum Press, London (1977).

    Google Scholar 

  68. R. D. Specian, and M. R. Neutra, (personal communication).

    Google Scholar 

  69. D. L. Freed, and C. H. Buckley, Mucotractive effect of lectin, Lancet 1: 585 (1978).

    Article  PubMed  CAS  Google Scholar 

  70. A. M. Lake, K. J. Block, M. R. Neutra, and W. A, Walker, Intestinal goblet cell mucus release, J. Immunol. 112: 834 (1979).

    Google Scholar 

  71. G. Forstner, M. Shih, and B. Lukie, Cyclic AMP and intestinal glycoprotein synthesis: the effect of β-adrenergic agents, theophylline, and dibutyryl cyclic AMP, Can. J. Physiol. Pharmacol. 51: 122 (1973).

    Article  PubMed  CAS  Google Scholar 

  72. H. L. Elliot, C. C. J. Carpenter, R. B. Sack, and J. H. Yardley., Small bowel morphology in experimental canine cholera, A light and electron microscopic study, Lab. Invest. 22: 112 (1970).

    Google Scholar 

  73. H. W. Moon, S. C. Whipp, and A. L, Baetz, Comparative effects of enterotoxin from Escherichia coli and Vibrio cholerae on rabbit and swine small intestine, Lab. Invest. 25: 133 (1971).

    PubMed  CAS  Google Scholar 

  74. J. H. Yardley, T. M. Bayless, E. H. Leubbers, C. H. Holland, and T. R. Hendrix, Goblet cell mucus in the small intestine. Findings after net fluid production due to cholera toxin and hypertonic solutions, Johns Hopkins Med. J. 130–131: 1 (1972).

    Google Scholar 

  75. S. E. Steinberg, J. G. Banwell, J. H. Yardley, G. T. Keusch, and T. R. Hendrix, Comparison of secretory and histological effects of Shigella and cholera enterotoxins in rabbit jejunum, Gastroent. 68: 309 (1975).

    CAS  Google Scholar 

  76. H. P. Sherr, B. R. Mertens, and R. Broock, Cholera toxin-induced glycoprotein secretion in rabbit small intestine, Gastroent. 77: 18 (1979).

    CAS  Google Scholar 

  77. R. J. Gibbons, and I. Dankers, Lectin-like constituents of foods which react with components of serum, saliva and streptococcus mutans, Appl. Environ. Bacteriol. (In press).

    Google Scholar 

  78. J. F. Forstner, N. W. Roomi, R. E. F. Fahim, and G. G. Forstner, Cholera toxin stimulates secretion of immunoreactive mucin, Am. J. Physiol. 3: G10 (1981).

    Google Scholar 

  79. R. D. Specian, and M. R. Neutra, Mucous granule transport and secretion: effects of colchicine and cytochalasin B, J. Cell Biol. 87: 278 (1980).

    Google Scholar 

  80. J. R. Martinez, E. Adelstein, D. Quissell, and G. Barbero, The chronically reserpinized rat as a possible model for cystic fibrosis. 1. Submaxillary gland morphology and ultrastructure, Pediat. Res. 9: 463 (1975).

    Article  PubMed  CAS  Google Scholar 

  81. T. P. Mawhinney, M. S. Feather, I. Q. Martinez, and G. J. Barbero, The chronically reserpinized rat as an animal model for cystic fibrosis: acute effect of isoproterenol and pilocarpine upon pulmonary lavage fluid, Pediat. Res. 13: 760 (1979).

    Article  PubMed  CAS  Google Scholar 

  82. M. E. Setser, S. S. Spicer, J. A. V. Simpson, M. Adamson, and J. R. Martinez, The effects of reserpine on the ultra-structure and secondary response of rat exocrine pancreas, Exper. Mol. Pathol. 31: 413 (1979).

    Article  CAS  Google Scholar 

  83. T. P. Mawhinney, J. R. Martinez, M. S. Feather and G. J. Barbero, Effects of kinin, peptides and prostaglandins on glycoprotein release by the perfused trachea of control and reserpine treated rats, presented at the 21st annual meeting of the Cystic Fibrosis Club, San Antonio, Texas, April 29, 1980 (abstract).

    Google Scholar 

  84. R. Frates, J. Last and T. Kaizu, Mucus glycoproteins secreted by cultured airway tissue from human subjects with and without cystic fibrosis, presented at the 20th annual meeting of the Cystic Fibrosis Club, Atlanta, Georgia, May 1, 1979 (abstract).

    Google Scholar 

  85. M. R. Neutra, R. J. Grand, and J. S. Trier, Glycoprotein synthesis, transport and secretion by epithelial cells of human rectal mucosa, Lab. Invest. 36: 535 (1977).

    PubMed  CAS  Google Scholar 

  86. S. M. Morrissey, and M. C. Tymvios, Acid mucins in human intestinal goblet cells, J. Path. 126: 197 (1978).

    Article  PubMed  CAS  Google Scholar 

  87. Z. Dische, P. Di Sant’Agnese, C. Pallavicini, and J. Youlos, Composition of mucoprotein fractions from duodenal fluid of patients with cystic fibrosis of the pancreas and from controls, Paed. 24: 74 (1959).

    CAS  Google Scholar 

  88. Z. Dische, Reciprocal relation between fucose and sialic acid in mammalian glycoproteins, Ann. N.Y. Acad. Sci. 106: 259 (1963).

    Article  PubMed  CAS  Google Scholar 

  89. M. I. Filipe, Value of histochemical reactions from mucosubstances in the diagnosis of certain pathological conditions of the colon and rectum, Gut 10: 577 (1969).

    Article  PubMed  CAS  Google Scholar 

  90. M. I. Filipe, and A. C. Branfoot, Abnormal patterns of mucus secretion in apparently normal mucosa of large intestine with carcinoma, Cancer 34: 282 (1974).

    Article  PubMed  CAS  Google Scholar 

  91. M. I. Filipe, Mucous secretion in rat colonic mucosa during carcinogenesis induced by dimethylhydrazine, Br. J. Cancer 32: 60 (1975).

    Article  PubMed  CAS  Google Scholar 

  92. D. V. Gold, and F. Miller, Comparison of human colonic mucoprotein antigen from normal and neoplastic mucosa, Cancer Res. 38: 3204 (1978).

    PubMed  CAS  Google Scholar 

  93. C. M. Rogers, K. B. Cooke, and M. I. Filipe, Sialic acids of human large bowel mucosa: 0-acylated variants in normal and malignant states, Gut 19: 587 (1978).

    Article  PubMed  CAS  Google Scholar 

  94. C. F. Culling, P. E. Reid, J. Worth, and W. L. Dunn, A new histochemical technique of use in the interpretation and diagnosis of adenocarcinoma and villous lesions in the large intestine, J. Clin. Path. 30: 1056 (1977).

    Article  PubMed  CAS  Google Scholar 

  95. P. A. Dawson, J. Patel, and M. I. Filipe, Variations in sialomucins in the mucosa of the large intestine in malignancy: a quantimet and statistical analysis, Histochem. J. 10: 559 (1978).

    Article  PubMed  CAS  Google Scholar 

  96. Y. S. Kim, and R. Isaacs, Glycoprotein metabolism in inflammatory and neoplastic diseases of the human colon, Cancer. Res. 35: 2092 (1975).

    PubMed  CAS  Google Scholar 

  97. I. Davidson, S. Kovarik, and L. Y. Ni, Isoantigens A, B and H in benign and malignant lesions of the cervix, Arch. Pathol. 87: 306 (1969).

    Google Scholar 

  98. T. A. O’Gorman, and J. T. LaMont, Glycoprotein synthesis and secretion in human colon cancers and normal colonic mucosa Cancer Res. 38: 2784 (1978).

    PubMed  Google Scholar 

  99. P. A. Dawson, and M. I. Filipe, A comparison of (3H) galactose and (3H) fucose uptake with the morphological and histochemical changes observed in mucous secretion in chemically induced rat colonic carcinoma, Histochem. J. 12: 23 (1980).

    Article  PubMed  CAS  Google Scholar 

  100. I. P. Hakkinen, FSA-foetal sulphoglycoprotein antigens associated with gastric cancer, Transplant. Rev. 20: 61 (1974).

    PubMed  CAS  Google Scholar 

  101. H. Munakata, and Z. Yosizawa, Isolation and characterization of a sulfated glycoprotein from a transplantable colorectal adenocarcinoma of rat, Biochim. Biophys. Acta 623: 412 (1980).

    PubMed  CAS  Google Scholar 

  102. D. M. Goldenberg, C. A. Pegram, and J. I. Vazquez, Identification of a colon specific antigen in normal and neoplastic tumor, J. Immunol. 114: 1008 (1975).

    PubMed  CAS  Google Scholar 

  103. D. V. Gold, and F. Miller, Chemical and immunological differences between normal and tumoral colonic mucoproteins, Nature 255: 85 (1975).

    Article  PubMed  CAS  Google Scholar 

  104. W. Rapp, M. Windisch, P. Peschke, and W. Wurster, Purification of a human intestinal goblet cell antigen (GoA). Its immunological demonstration in the intestine and mucus producing gastrointestinal adenocarcinomas, Virchows Arch. (Pathol. Anat.) 382: 167 (1979).

    Article  Google Scholar 

  105. J. Bara, and P. Burtin, Mucus-associated gastrointestinal antigens in transitional mucosa adjacent to human colonic adenocarcinomas: their “fetal type” association, Eur. J. Cancer 16: 1303 (1980).

    PubMed  CAS  Google Scholar 

  106. M. I. Filipe, and I. M. P. Dawson, The diagnostic value of mucosubstances in rectal biopsies from patients with ulcerative colitis and Crohn’s disease, Gut 11: 229 (1970).

    Article  PubMed  CAS  Google Scholar 

  107. C. F. Culling, P. A. Reid, and W, L. Dunn, A histological comparison of 0-acylated sialic acids of the epithelial mucins in ulcerative colitis; Crohn’s disease and normal controls, J. Clin. Path. 32: 1272 (1979).

    Article  PubMed  CAS  Google Scholar 

  108. R. P. MacDermott, R. M. Donaldson, and J. S. Trier, Glycoprotein synthesis and secretion by mucosal biopsies of rabbit colon and human rectum, J. Clin. Invest. 54: 545 (1974).

    Article  PubMed  CAS  Google Scholar 

  109. G. Fraser, and J. R. Clamp, Changes in human colonic mucus in ulcerative colitis, Gut 16: 832 (1975).

    PubMed  CAS  Google Scholar 

  110. S. P. Lee, J. T. LaMont, and M. Carey, The prevention of cholesterol gallstones with aspirin, Gastroent. 78: 1205 (1980).

    Google Scholar 

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Authors and Affiliations

  1. Kinsmen Cystic Fibrosis Research Centre, Dept. of Paediatrics and Biochemistry, The Hospital for Sick Children and the University of Toronto, Toronto, Canada

    G. Forstner, A. Wesley & J. Forstner

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  1. G. Forstner
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  2. A. Wesley
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Editors and Affiliations

  1. Department of Obstetrics and Gynecology, University Hospital of South Manchester, Manchester, England

    Eric N. Chantler  & Max Elstein  & 

  2. University of Department of Surgery, Manchester Royal Infirmary, Manchester, England

    James B. Elder

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Forstner, G., Wesley, A., Forstner, J. (1982). Clinical Aspects of Gastrointestinal Mucus. In: Chantler, E.N., Elder, J.B., Elstein, M. (eds) Mucus in Health and Disease—II. Advances in Experimental Medicine and Biology, vol 144. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9254-9_32

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