Abstract
The kidney plays a key role in phosphorus (P)* homeostasis.1 The amount of phosphate (Pi) excreted by the kidney depends mostly on the extent to which Pi filtered in glomeruli is reabsorbed back to peritubular circulation in tubules.2 The bulk of the filtered Pi is reabsorbed in the proximal tubule2 and the first step in the mechanism of Pi transport from the lumen across the proximal tubule epithelium is a Na+-dependent Pi uptake across the luminal brush border membrane (BBM).3,4 Studies on 32Pi uptake by BBM vesicles isolated from the renal cortex allows analysis of this initial step in tubular Pi reabsorption in a variety of pathophysiologic situations, independent of immediate supply of energy from tubular cell metabolism and independent of other factors which could contribute to or regulate overall proximal tubular Pi reabsorption in situ.
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Dousa, T.P., Kempson, S.A., Shah, S.V. (1980). Adaptive Changes in Renal Cortical Brush Border Membrane. In: Massry, S.G., Ritz, E., Jahn, H. (eds) Phosphate and Minerals in Health and Disease. Advances in Experimental Medicine and Biology, vol 128. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9167-2_8
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DOI: https://doi.org/10.1007/978-1-4615-9167-2_8
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