Abstract
Most physicians regard varicella (chicken pox), primary infection with varicella-zoster virus (VZV), as merely a mild infection of childhood. It might even be viewed by some as a prerequisite of normal growth and development, a traditional milestone that almost all individuals have endured and that new generations ought to endure as well. Clearly, however, this is an old-fashioned view. Recent advances in medical treatment such as chemotherapy of childhood cancer and organ transplantation require clinicians and virologists to reassess the impact of this disease today.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Arbeter, A. M., Starr, S. E., Weibel, R. E., and Plotkin, S. A., 1982, Live attenuated varicella vaccine: Immunization of healthy children with the OKA strain, J. Pediati. 100:886–893.
Arbeter, A. M., Starr, S. E., Weibel, R. E., Neff, B. J., and Plotkin, S. A., 1983, Live attenuated varicella vaccine: The KMcC strain in healthy children, Pediatrics 71:307–312.
Arvin, A., Koropchak, C. M., and Wittek, A. E., 1983, Immunologic evidence of reinfection with varicella-zoster virus, J. Infect. Dis. 148:200–205.
Asano, Y., and Takahashi, M., 1977, Clinical and serologic testing of a live varicella vaccine and two-year follow-up for immunity of the vaccinated children, Pediatrics 60:810–814.
Asano, Y., Nakayama, H., Yazaki, T., Kato, R., Hirose, S., Tsuzuki, K., Ito, S., Isomura, S., and Takahashi, M., 1977, Protection against varicella in family contacts by immediate inoculation with live varicella vaccine, Pediatrics 59:3–7.
Asano, Y., Albrecht, P., Vujcic, L. K., Quinnan, G. V., Kawakami, K., and Takahashi, M., 1983, Five-year follow-up study of recipients of live varicella vaccine using enhanced neutralization and fluorescent antibody membrane antigen assays, Pediatrics 72:291–294.
Baba, K., Yabuuchi, H., Okuni, H., and Takahashi, M., 1978, Studies with live varicella vaccine and inactivated skin test antigen: Protective effect of the vaccine and clinical application of the skin test, Pediatrics 61:550–555.
Bogger-Goren, S., Baba, K., Hurly, P., Yabuuchi, H., Takahashi, M., and Ogra, P. L., 1982, Antibody response to varicella-zoster virus after natural or vaccine-induced infection, J. Infect. Dis. 146:260–265.
Brunell, P., 1975, Live varicella vaccine [letter], Lancet 1:98.
Brunell, P., 1977a, Protection against varicella: Commentary, Pediatrics 59:1–2.
Brunell, P., 1977b, Brunell’s brush off [letter], Pediatrics 59:954.
Brunell, P., Gershon, A., Uduman, S. A., and Steinberg, S., 1975, Varicella-zoster immunoglobulins during varicella, latency, and zoster, J. Infect. Dis. 132:49–54.
Brunell, P., Geiser, C., Shehab, Z., and Waugh, J. E., 1983, Administration of live varicella vaccine to children with leukemia, Lancet 2:1069–1072.
Cheatham, W. J., Weiler, T. H., Dolan, T. F., and Dower, J. C., 1956, Varicella: Report of two fatal cases with necropsy, virus isolation, and serologic studies, Am. J. Pathol. 32:1015–1028.
Feldman, S., Hughes, W. T., and Daniel, C. B., 1975, Varicella in children with cancer: 77 cases, Pediatrics 56:388–397.
Gershon, A., 1980, Live attenuated varicella-zoster vaccine, Rev. Infect. Dis. 2:393–405.
Gershon, A., Steinberg, S., and Brunell, P. A., 1974, Zoster immune globulin: A further assessment, N. Engl. J. Med. 290:243–245.
Gershon, A., Steinberg, S., Borkowsky, W., Lennette, D., and Lennette, E., 1982, IgM to varicella-zoster virus: Demonstration in patients with and without clinical zoster, Pe-diatr. Infect. Dis. 1:164–167.
Gershon, A., Steinberg, S., Gelb, L., Galasso, G., Borkowsky, W., LaRussa, P., Ferrara, A., and the National Institute of Allergy and Infectious Diseases Varicella Vaccine Collaborative Study Group, 1984a, Live attenuated varicella vaccine: Efficacy for children with leukemia in remission, J. Am. Med. Assn. 252:355–362.
Gershon, A., Steinberg, S., and Gelb, L., 1984b, Clinical reinfection due to varicella-zoster virus, J. Infect. Dis. 149:137–142.
Ha, K., Baba, K., Ikeda, T., Nishida, M., Yabuuchi, H., and Takahashi, M., 1980, Application of live varicella vaccine to children with acute leukemia or other malignancies without suspension of anticancer therapy, Pediatrics 65:346–350.
Hope-Simpson, R. E., 1965, The nature of herpes zoster: A long-term study and a new hypothesis, Proc. R. Soc. Med. 58:1–12.
Izawa, T., Ihara, T., Hattori, A., Iwasa, T., Kamiya, H., Sakurai, M., and Takahashi, M., 1977, Application of a live varicella vaccine in children with acute leukemia or other malignant diseases, Pediatrics 60:805–809.
Kempe, H., and Gershon, A., 1977, Varicella vaccine at the crossroads, Pediatrics 60:930–931.
Martin, J. H., Dohner, D. E., Wellinghoff, W. J., and Gelb, L. D., 1982, Restriction endon-uclease analysis of varicella-zoster vaccine virus and wild-type DNAs, J. Med. Virol. 9:69–76.
Neff, B. J., Weibel, R. E., Villarejos, V. M., Buynak, E. B., McLean, A. A., Morton, D. H., Wolanski, B. S., and Hilleman, M. R., 1981, Clinical and laboratory studies of KMcC strain live attenuated varicella virus, Proc. Soc. Exp. Biol Med. 166:339–347.
Plotkin, S. A., 1977, Varicella vaccine: Plotkin’s plug [letter], Pediatrics 59:954.
Ross, A. H., Lencher, E., and Reitman, G., 1962, Modification of chickenpox in family contacts by administration of gamma globulin, N. Engl. J. Med. 267:369–376.
Sabin, A. B., 1977, Varicella-zoster virus vaccine: Commentary, J. Am. Med. Assoc. 1731–1733.
Sakurai, M., Ihara, T., Ito, M., Hirai, S., Iwasa, T., Oitani, K., Kamiya, H., Izawa, T., and Takahashi, M., 1982, Application of a live varicella vaccine in children with acute leukemia, in: Herpesvirus: Clinical, Pharmacological, and Basic Aspects (H. Shiota, Y.-C. Cheng, and W. H. Prusoff, eds.), pp. 87–93, Excerpta Medica, Amsterdam.
Steele, R. W., Coleman, M. A., Fiser, M., and Bradsher, R. W., 1982, Varicella zoster in hospital personnel: Skin test reactivity to monitor susceptibility, Pediatrics 70:604–608.
Takahashi, M., Otsuka, T., Okuno, Y., Asano, Y., Yazaki, T., and Isomura, S., 1974, Live varicella vaccine used to prevent the spread of varicella in children in hospital, Lancet 2:1288–1290.
Weibel, R. E., Neff, B. J., Kuter, B. J., Guess, H. A., Rothenberger, C. A., Fitzgerald, A. J., Connor, K. A., McLean, A. A., Hilleman, M. R., Buynak, E. B., and Skolnick, E. M., 1984, Live attenuated varicella virus vaccine. Efficacy trial in healthy children. N. Engl. J. Med. 310:1409–1415.
Whitley, R., Hilty, M., Haynes, R., Bryson, Y., Connor, J. D., Soong, S.-J., Alford, C. A., and the National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group, 1982, Vidarabine therapy of varicella in immunosuppressed patients, J. Pediati. 101:125–131.
Williams, V., Gershon, A., and Brunell, P. A., 1974, Serologic response to varicella-zoster membrane antigens measured by indirect immunofluorescence, J. Infect. Dis. 130:669–672.
Yamanishi, H., Matsunaga, Y., Ogino, T., and Lopetegui, P., 1981, Biochemical transformation of mouse cells by varicella-zoster virus, J. Gen. Virol. 56:421–430.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Plenum Press, New York
About this chapter
Cite this chapter
Gershon, A.A. (1985). Live Attenuated Varicella Vaccine. In: Roizman, B., Lopez, C. (eds) The Herpesviruses. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8021-8_15
Download citation
DOI: https://doi.org/10.1007/978-1-4615-8021-8_15
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-8023-2
Online ISBN: 978-1-4615-8021-8
eBook Packages: Springer Book Archive