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The Herpesviruses

Immunobiology and Prophylaxis of Human Herpesvirus Infections

  • Bernard Roizman
  • Carlos Lopez

Part of the The Viruses book series (VIRS)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. A. A. Nash, K.-N. Leung, P. Wildy
    Pages 87-102
  3. Barry T. Rouse
    Pages 103-119
  4. Gerald V. Quinnan Jr.
    Pages 121-145
  5. Eva Klein
    Pages 171-182
  6. Gary R. Pearson
    Pages 183-199
  7. Stanley A. Plotkin
    Pages 297-312
  8. Anne A. Gershon
    Pages 313-326
  9. M. A. Epstein
    Pages 327-337
  10. François Lebel, Martin S. Hirsch
    Pages 371-393
  11. Back Matter
    Pages 417-430

About this book

Introduction

'You damn sadist/said mr cummings 'you try to make people think. ' -Ezra Pound (Canto 89) What makes herpesviruses unique? It is certainly not the size of their genomes or the individual features of their reproductive cycle, although in toto striking features that are exclusive to the herpesviruses abound. Unquestionably, the pre-eminent feature is the relationship of herpes­ viruses with their natural hosts. As described in preceding volumes, all herpesviruses seem to be able to colonize and to remain in a latent, nonproductive form for life of their hosts. Once established in the host, the relationship is best described as that of an armed truce. What happens when this truce breaks down or when the host encounters the virus for the first time is the subject of this volume. We have focused primarily on the five human herpesviruses [herpes simplex virus 1 (HSV-l), herpes simplex virus 2 (HSV-2), cytomegalovirus (CMV), varicella zoster virus (VZV) and Epstein-Barr virus (EBV)] because much more is known about them than about any other herpesviruses, and because it is of interest to compare both the diversity of manifestations of infections with human herpesviruses and the spectrum of human responses to these viruses. This volume summarizes the current knowledge of the pathogenesis and immunobiology of herpesvirus infections in man and describes new and developing approaches to prophylaxis and treatment. It contains con­ tributions from distinguished research scientists presently engaged at the forefront of these scientific investigations.

Keywords

Pathogene biology infection infections pathogenesis virus

Editors and affiliations

  • Bernard Roizman
    • 1
  • Carlos Lopez
    • 2
  1. 1.University of ChicagoChicagoUSA
  2. 2.Sloan-Kettering Institute for Cancer ResearchNew YorkUSA

Bibliographic information