Enzymes Involved in the Catalysis of Catecholamine Biosynthesis

Goldstein, M.

doi:10.1007/978-1-4615-7748-5_13

M. Goldstein³

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28 Citations

Abstract

The postulated biosynthetic pathway (Blaschko, 1939) for the formation of the adrenergic transmitters (Fig. 1) was the subject of several studies and was confirmed with the use of radioactive labeled precursors. Three enzymes are involved in the catalysis of norepinephrine biosynthesis: tyrosine hydroxylase (TH), dopa decarboxylase (DDC), and dopamines-hydroxylase (DβH; a fourth enzyme, namely, phenylethanolamine-N-methyltransferase (PNMT) catalyzes the biosynthesis of epinephrine from norepinephrine. Two enzymes, namely, TH and DβH, can be classified as mixed-function oxidase (Mason, 1957) or monooxygenase (Hayaishi, 1964). The general reaction catalyzed by monooxygenases is shown in Reaction (1) where RH stands for the substrate to be hydroxylated, ROH for the hydroxylated product, and XH₂ for the electron donor.

Research Scientist Awardee of USPHS, NIH Grant MH-14918.

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Department of Psychiatry, Neurochemistry Laboratories, New York University Medical Center, New York, New York, USA
M. Goldstein

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New York State Research Institute, Neurochemistry and Drug Addiction, Ward’s lsland, New York, New York, USA
Neville Marks
Department of Biochemistry, Institute Psychiatry, University of London, London, Great Britain
Richard Rodnight

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Goldstein, M. (1972). Enzymes Involved in the Catalysis of Catecholamine Biosynthesis. In: Marks, N., Rodnight, R. (eds) Research Methods in Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7748-5_13

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