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Cell-Surface Differentiation in the Mouse

Characterization of “Jumping” and “Lineage” Antigens Using Xenogeneic Rat Monoclonal Antibodies

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Monoclonal Antibodies

Abstract

Differentiation is the process whereby indifferent cells give rise to specialized tissues and cellular subpopulations with distinctive characteristics. This involves the coordinated control of many different genes, some of which affect the expression of molecules at the cell surface. Those molecules that can be identified with antibodies and are expressed on some but not all tissues are called differentiation antigens (Boyse and Old, 1969). Both qualitative and quantitative variations occur in the expression of differentiation antigens.

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Author information

Authors and Affiliations

  1. Pathology Department, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Timothy A. Springer

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  1. Timothy A. Springer
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Editors and Affiliations

  1. University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

    Roger H. Kennett  & Thomas J. McKearn  & 

  2. The Wistar Institute, Philadelphia, Pennsylvania, USA

    Kathleen B. Bechtol

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© 1980 Plenum Press, New York

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Springer, T.A. (1980). Cell-Surface Differentiation in the Mouse. In: Kennett, R.H., McKearn, T.J., Bechtol, K.B. (eds) Monoclonal Antibodies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7505-4_12

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  • DOI: https://doi.org/10.1007/978-1-4615-7505-4_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-7507-8

  • Online ISBN: 978-1-4615-7505-4

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