Abstract
Numerous reports have provided evidence to suggest that chemotransduction in the type I carotid body cell involves hypoxic inhibition of K+ channels, which leads to cell depolarization, opening of voltage-gated Ca2+ channels and the consequent influx of Ca2+, which triggers neurosecretion (González et al, 1994; Peers & Buckler, 1995). In adult rabbit type I cells, hypoxia inhibits K+ channels in a membrane-delimited, possibly direct manner (Ganfornina & López-Barneo, 1991). However, in type I cells of young (approximately 10 days old) rats, hypoxia inhibits K+ channels via a mechanism which involves an as yet unidentified cytosolic factor (Wyatt & Peers, 1995).
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© 1996 Springer Science+Business Media New York
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Hatton, C.J., Peers, C. (1996). Cyclic Nucleotide Analogs do not Interfere with Hypoxic Inhibition of K+ Currents in Isolated Rat Type I Carotid Body Cells. In: Zapata, P., Eyzaguirre, C., Torrance, R.W. (eds) Frontiers in Arterial Chemoreception. Advances in Experimental Medicine and Biology, vol 410. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5891-0_13
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DOI: https://doi.org/10.1007/978-1-4615-5891-0_13
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