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Transduction of chemostimuli by the type I carotid body cell

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Summary

The postulated mechanisms for hypoxic and acidic chemotransduction by type I cells that we have described here are summarized in the diagrams of Fig. 4. Most if not all of these require more complete evaluation and, as we have described, there are obvious points of contention that need to be resolved. Nevertheless, it is apparent that studies of isolated type I cell preparations carried out over the last six years have provided significant advancements in our understanding of chemotransduction in the type I cell. Only when the functioning of these cells has been fully described can we hope to understand the mechanisms underlying the responses of the intact organ to chemostimuli.

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Authors and Affiliations

  1. Institute for Cardiovascular Research, Leeds University, LS2 9JT, Leeds, UK

    C. Peers

  2. University Laboratory of Physiology, Parks Road, OX1 3PT, Oxford, UK

    K. J. Buckler

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  1. C. Peers
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Many of the findings reported here, including those to which the authors have contributed, were supported by The Wellcome Trust. We are also grateful to colleagues for allowing us to reproduce parts of their data.

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Peers, C., Buckler, K.J. Transduction of chemostimuli by the type I carotid body cell. J. Membarin Biol. 144, 1–9 (1995). https://doi.org/10.1007/BF00238411

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