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Multiple roles of the proliferating cell nuclear antigen: DNA replication, repair and cell cycle control

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Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

The proliferating cell nuclear antigen (PCNA), the auxiliary protein of DNA polymerases δ and ε, is involved in DNA replication and repair. This protein forms a homotrimeric structure which, encircling DNA, loads the polymerase on the DNA template. A role for PCNA in the cell cycle control is recognised on the basis of the interaction with cyclins, cyclin-dependent kinases (cdks) and the cdk-inhibitor p21 waf1/cip1/sdi1 protein. Association with the growth-arrest and DNA-damage inducible proteins gadd45 and MyD118, further demonstrates the role of PCNA as a component of the cell cycle control apparatus.

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  1. Centro di Studio per l’Istochimica del CNR, Dipartimento di Biologia Animale, Università di Pavia, Piazza Botta 10, 27100, Pavia, Italy

    Ennio Prosperi

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  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer  & Silvana Guidet  & 

  2. Centre National de la Recherche Scientifique, Université de Rennes I, Rennes, France

    Michel Philippe

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Prosperi, E. (1997). Multiple roles of the proliferating cell nuclear antigen: DNA replication, repair and cell cycle control. In: Meijer, L., Guidet, S., Philippe, M. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5371-7_15

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  • DOI: https://doi.org/10.1007/978-1-4615-5371-7_15

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