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Human gene for proliferating cell nuclear antigen has pseudogenes and localizes to chromosome 20

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Somatic Cell and Molecular Genetics

Abstract

We have isolated from a human genomic library a pseudogene of the proliferating cell nuclear antigen (PCNA)gene. Its sequence shows a 78% similarity with the human PCNA/cDNA. The PCNAgene is located on human chromosome 20, while the pseudogene maps to chromosome region Xpter→Xq13. An additional locus detected by the full-length PCNA cDNA, but not by intron probes, segregates concordantly with chromosome region 6p12→6pter and probably represents a second pseudogene.

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Authors and Affiliations

  1. Department of Pathology and Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania

    De-Hui Ku, Salvatore Travali, Bruno Calabretta, Kay Huebner & Renato Baserga

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  1. De-Hui Ku
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  2. Salvatore Travali
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  3. Bruno Calabretta
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  4. Kay Huebner
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  5. Renato Baserga
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Ku, DH., Travali, S., Calabretta, B. et al. Human gene for proliferating cell nuclear antigen has pseudogenes and localizes to chromosome 20. Somat Cell Mol Genet 15, 297–307 (1989). https://doi.org/10.1007/BF01534969

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  • DOI: https://doi.org/10.1007/BF01534969

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