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A Cdc7p-Dbf4p protein kinase activity is conserved from yeast to humans

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Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

DBF4 and CDC7 were identified as budding yeast cell cycle mutants that arrest immediately before S phase. The Dbf4p and Cdc7p proteins interact to form a protein kinase, Cdc7p being the catalytic subunit and Dbf4p is a cyclin-like molecule that activates the kinase in late Gl. Dbf4p also targets Cdc7p to origins of replication where likely substrates include the Mcm proteins. Dbf4p and Cdc7p related proteins occur in the fission yeast and in metazoans. These also phosphorylate Mcm proteins and preliminary evidence indicates a similar function to Dbf4p/Cdc7p in budding yeast. The Dbf4p/Cdc7p activity will therefore very likely be conserved in all eukaroytes.

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Author information

Authors and Affiliations

  1. Division of Yeast Genetics, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK

    Leland H. Johnston

  2. Department of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan

    Hisao Masai

  3. Department of Biochemistry and Molecular Biology, Research Institute for Microbial Diseases Osaka University, 3-1 Yamada-oka, Suita, Osaka, 565-0871, Japan

    Akio Sugino

Authors
  1. Leland H. Johnston
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  2. Hisao Masai
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  3. Akio Sugino
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Editor information

Editors and Affiliations

  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer  & Armelle Jézéquel  & 

  2. Centre National de la Recherche Scientifique, Université Paul Sabatier, Toulouse, France

    Bernard Ducommun

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© 2000 Springer Science+Business Media New York

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Johnston, L.H., Masai, H., Sugino, A. (2000). A Cdc7p-Dbf4p protein kinase activity is conserved from yeast to humans. In: Meijer, L., Jézéquel, A., Ducommun, B. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4253-7_6

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  • DOI: https://doi.org/10.1007/978-1-4615-4253-7_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6909-7

  • Online ISBN: 978-1-4615-4253-7

  • eBook Packages: Springer Book Archive

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