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Gastrointestinal Toxicology of Monogastrics

  • Chapter
Gastrointestinal Microbiology

Part of the book series: Chapman & Hall Microbiology Series ((CHMBS))

Abstract

The gastrointestinal tract is one of the most active sites in the body where metabolism takes place. A large number of microorganisms are found in the gastrointestinal tract. The number of microorganisms per gram colon contents exceeds 1011/g dry weight, constituting more than 40% of the total fecal mass (Stephen and Cummings 1980). These microorganisms represent a sources of great metabolic power and may play a role in many disease processes including cancer (Goldin 1986a,b, 1990, Gorbach and Goldin 1990, Hill 1987, Mallett and Rowland 1990). The microbiota produce a wide range of substances de novo and/or from ingested sources including the diet. These toxic substances may be mutagens, tumor promoters, initiators or carcinogens in addition to many types of toxins. Toxins are defined as chemicals which have adverse effects on living systems. Toxicology today involves studies of the effects of specific substances on any biological system, whether a whole organism, organ or tissue, through the interaction of toxin with target.

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References

  • Aguero J, Faundez G, Nunez M, Wormser GP, Lieberman JP, Gabello FC (1991) Choleri-form syndrome and production of labile enterotoxin (CT/LT1)-like antigen by species of Salmonella infantis and Salmonella haardt isolated from the same patients. Rev Infect Diseases 13: 420–423.

    Article  CAS  Google Scholar 

  • Alvares AP (1984) Environmental influences on drug bio-transformations in humans. World Rev Nutr Diet 43: 45–49.

    PubMed  CAS  Google Scholar 

  • Ames BN (1983) Dietary carcinogens and anticarcinogens. Science 221: 1256–1264.

    Article  PubMed  CAS  Google Scholar 

  • Ames BN (1986) Food constituents as a source of mutagens, carcinogens, and anticarcinogens. In: Genetic Toxicology of the Diet, pp. 3–32. New York: Alan R. Liss.

    Google Scholar 

  • Amirmozafari N, Robertson DC (1993) Nutritional requirements for synthesis of heat-labile enterotoxin by Yersinia enterocoliticca. Appl Environ Microbiol 59: 3314–3320.

    PubMed  CAS  Google Scholar 

  • Anand A, Bashey B, Mir T, Glatt AE (1994) Epidemiology, clinical manifestations, and outcome of Clostridium difficile associated diarrhea. Am J Gastroenterol 89: 519–523.

    PubMed  CAS  Google Scholar 

  • Aponte GE, Triolo HJ, Herr DL (1977) Induction of aryl hydrocarbon hydroxylase and forestomach tumors by benzo(a)pyrene. Cancer 37: 3018–3021.

    Google Scholar 

  • Arnold DL, Munro IC (1983) Artificial sweeteners: their toxicological etiology is an interesting mix. In: Wynder EL, Leveille GA, Weisburger JH, Livingston GE, eds., Environmental Aspects of Cancer: The Role of Macro and Micro Components of Foods, pp. 211–229. Westport, Conn: Food and Nutrition Press.

    Google Scholar 

  • Arnold DL, Clayson DB (1985) Saccharin — a bitter-sweet case. In: Clayson DB, Krewski D, Munro I, eds., Toxicological Risk Assessment, pp. 227–244. Boca Raton, Fla: CRC Press.

    Google Scholar 

  • Astill BD, Mulligan LT (1977) Phenolic antioxidants and the inhibition of hepatotoxicity from N-dimethylnitrosamine formed in situ in the rat stomach. Food Cosmet Toxicol 15: 167–171.

    Article  PubMed  CAS  Google Scholar 

  • Azad Khan AKA, Guthrie G, Johnson HH, Truelove SC, Williamson DH (1983) Tissue and bacterial splitting of sulphasalazine. Clin Sci 64: 349–354.

    PubMed  CAS  Google Scholar 

  • Baden DG, Mende TJ, Poli MA, Block RE (1984) Toxins from Florida’s red tide dinoflagellate, Ptychodiscus brevis. In: Ragelis EP, ed. Seafood Toxins. Washington, DC: American Chemical Society.

    Google Scholar 

  • Bailey JA, Mansfield JW (1982) Phytoalexins. New York: Wiley.

    Google Scholar 

  • Balish E (1986) Intestinal flora and natural immunity. Microecol Ther 16: 157–167.

    Google Scholar 

  • Becher G, Knize MG, Nes IF, Felton JS (1988) Isolation and identification of mutagen from a fried Norwegian meat product. Carcinogenesis 9: 247–253.

    Article  PubMed  CAS  Google Scholar 

  • Belman S (1983) Onion and garlic oils inhibit tumor promotion. Carcinogenesis 4: 1063–1065.

    Article  PubMed  CAS  Google Scholar 

  • Bender AE (1987) Effect on nutritional balance: antinutrients. In: Watson DH, ed., Natural Toxicants in Foods, Progress and Prospects, pp. 110–124, New York: VCH Publishers.

    Google Scholar 

  • Betley MJ, Lofdahl S, Kreiswirth BN, Bergdoll MS, Novick RP (1984) Staphylococcal enterotoxin A gene is associated with a variable genetic element. Proc Natl Acad Sci USA 81: 5179–5183.

    Article  PubMed  CAS  Google Scholar 

  • Betley MJ, Virginia LM, Mekalanos JJ (1986) Genetics of bacterial enterotoxins. Annu Rev Microbiol 40: 577–605.

    Article  PubMed  CAS  Google Scholar 

  • Beuchat LR, Golden DA (1989) Antimicrobials occurring naturally in foods. Food Technol 43: 134–142.

    CAS  Google Scholar 

  • Birt DF (1989) Dietary inhibition of cancer. In: Ragsdale NN, Menzer RE, eds. Carcinogenicity and Pesticides: Principles, Issues, and Relationships, pp. 107–121. Washington, DC: American Chemical Society.

    Chapter  Google Scholar 

  • Black SD (1992) Membrane topology of the mammalian P450 cytochromes. FASEB J 6: 680–685.

    PubMed  CAS  Google Scholar 

  • Bock KW (1977) Dual role of glucuronyl and sulfotransferases converting xenobiotics into reactive or biologically inactive and easily excretable compounds. Arch Toxicol 39: 77–85.

    Article  PubMed  CAS  Google Scholar 

  • Bohach GA, Fast DJ, Nelson RD, Schlievert PM (1990) Staphylococcal and streptococcal pyrogenic toxins involved in toxic shock syndrome and related diseases. Crit Rev Microbiol 17: 251–272.

    Article  PubMed  CAS  Google Scholar 

  • Bokkenheuser VD, Shackleton CHL, Winter J (1987) Hydrolysis of dietary flavonoid glycosides by strains of intestinal anaerobes from humans. Biochem J 248: 953–956.

    PubMed  CAS  Google Scholar 

  • Bowden JP, Chung KT, Andrews AW (1976) Mutagenic activity of tryptophan metabolites produced by rat intestinal microflora. J Natl Cancer Inst 57: 921–924.

    PubMed  CAS  Google Scholar 

  • Boyd SC, Sasame HA, Boyd MR (1979) High concentrations of glutathione in glandular stomach: possible implications for carcinogenesis. Science 205: 1010–1012.

    Article  CAS  Google Scholar 

  • Bresinsky A, Besl H (1990) A Colour Atlas of Poisonous Fungi: A Handbook for Pharmacists, Doctors and Biologists. London: Woolfe.

    Google Scholar 

  • Bryan GT (1969) Role of tryptophan metabolites in urinary bladder cancer. Am Indust Hyg Assoc J 30: 27–34.

    CAS  Google Scholar 

  • Bryan GT (1971) The role of tryptophan metabolites in the etiology of bladder cancer. Am J Clin Nutr 24: 841–847.

    PubMed  CAS  Google Scholar 

  • Bryan GT (1978) Nitrofurans: Chemistry, Metabolism, Mutagenesis and Carcinogenesis. New York: Raven.

    Google Scholar 

  • Butler L (1989) Polyphenols. In: Cheeke PR, ed., Toxicants of Plant Origin, Vol. 4. Phenolics. pp. 95–122. Boca Raton, Fla: CRC Press.

    Google Scholar 

  • Butler MA, Guengerich FP, Kadlubar FF (1989) Metabolic oxidation of the carcinogens 4-aminobiphenyl and 4, 4′-methylenebis(2-chloroaniline) by human hepatic microsomes and by purified rat hepatic cytochrome P-450 monooxygenase. Cancer Res 49: 25–31.

    PubMed  CAS  Google Scholar 

  • Callahan LT, III, Ryder RC, Richardson SH (1971) Biochemistry of Vibrio cholerae virulence. II. skin permeability factor cholera enterotoxin production in a chemically defined medium. Infect Immun 4: 611–618.

    PubMed  CAS  Google Scholar 

  • Callahan LT, Richardson SH (1973) Biochemistry of Vibrio cholerae virulence. III. Nutritional requirements for toxin production and the effects of pH on toxin elaboration in chemically defined media. Infect Immun 7: 767–774.

    Google Scholar 

  • Calorie Control Council (CCC) (1985) Alternative Sweeteners. Atlanta, Ga: Council.

    Google Scholar 

  • Cameron E, Pauling L (1976) Supplementary ascorbate in the supportive treatment of cancer: prolongation of survival times in terminal human cancer. Proc Natl Acad Sci USA 73: 3685–3689.

    Article  PubMed  CAS  Google Scholar 

  • Cameron E, Pauling L (1978) Supplementary ascorbate in the supportive treatment of cancer: prolongation of survival times in terminal cancer. Proc Natl Acad Sci USA 75: 4538–4542.

    Article  PubMed  CAS  Google Scholar 

  • Campbell RL, Singh DV, Nigis ND (1975) Importance of the fecal stream on the induction of colon tumors by azoxymethane in rats. Cancer Res 35: 1369–1371.

    PubMed  CAS  Google Scholar 

  • Carr CJ (1985) Food and drug interactions. In: Fenley JW, Schwass DE, eds., Xenobiotics in Food and Feeds, pp. 221–228. ACS Symposium 234. Washington, DC: American Chemical Society.

    Google Scholar 

  • Carey JB Jr (1973) Bile salt metabolism in man. In: Nair PP, Kritchevsky D, eds. Bile Acid, Vol. 2, pp. 62–63. New York: Plenum.

    Google Scholar 

  • Cerniglia CE, Howard PC, Fu PP, Franklin W (1984) Metabolism of nitropolycyclic aromatic hydrocarbons by human intestinal microflora. Biochem Biophys Res Commun 123: 262–270.

    Article  PubMed  CAS  Google Scholar 

  • Cerniglia CE (1985) Metabolism of 1-nitropyrene and 6-nitrobenzo(a)pyrene by intestinal microflora. Prog Clin Biol Res 181: 133–137.

    PubMed  CAS  Google Scholar 

  • Cerniglia CE, Zhuo Z, Manning BW, Federle TW, Heflich RH (1986) Mutagenic activation of the benzidine-based dye Direct Black by human intestinal microflora. Mutat Res 175: 11–16.

    Article  PubMed  CAS  Google Scholar 

  • Chadwick RW, George SE, Chang J, et al. (1991a) Potentiation of 2, 6-dinitrotoluene in Fisher 344 rats by pretreatment with pentachlorophenol. Pest Biochem Physiol 39: 168–181.

    Article  CAS  Google Scholar 

  • Chadwick RW, George SE, Chang J, et al. (1991b) Aroclor 1254 alters intestinal enzyme activity and biotransformation of 2, 6-dinitrotoluene in rats. Toxicologist 11: 255.

    Google Scholar 

  • Chadwick RW, George SE, Claxton LD (1992) Role of the gastrointestinal mucosa and microflora in the bioactivation of dietary and environmental mutagens or carcinogens. Drug Metab Rev 24(4): 425–492.

    Article  PubMed  CAS  Google Scholar 

  • Chadwick RW, George SE, Chang J, et al. (1993) Effects of age, species differences, antibiotics and toxicants on intestinal enzyme activity and genotoxicity. Environ Toxicol Chem 12: 1339–1352.

    Article  CAS  Google Scholar 

  • Chang GW, Bill J, Lum R (1989) Proportion of ß-D-glucuronidase-negative Escherichia coli in human fecal samples. Appl Environ Microbiol 55: 335–339.

    PubMed  CAS  Google Scholar 

  • Chary P, Prasad R, Chopra AK, Peterson JW (1993) Location of the enterotoxin gene from Salmonella typhimurium and characterization of the gene products. FEMS Microbiol Lett 111: 87–92.

    Article  PubMed  CAS  Google Scholar 

  • Chen LH, Boissonneault GA, Glauert HP (1989) Vitamin C, vitamin K and cancer (review). Anticancer Res 8: 739–748.

    Google Scholar 

  • Chen W, Nichols J, Zhou Y, et al. (1995) Effect of dietary restriction on glutathione-S-transferase activity specific toward Aflatoxin B1-8, 9-epoxide. Toxicol Lett. 78: 235–243.

    Article  PubMed  CAS  Google Scholar 

  • Chhabra RS, Eastin WC (1984) Intestinal absorption and metabolism of xenobiotics in laboratory animals: In: Schiller CM, ed., Intestinal Toxicology, pp. 145–160. New York: Raven Press.

    Google Scholar 

  • Chipley JR (1993) Sodium benzoate and benzoic acid. In: Davidson PM, Branen AL, eds. Antimicrobials in Foods, 2nd Ed., pp. 11–48. New York: Marcel Dekker.

    Google Scholar 

  • Chopra AK, Vo TN, Houston CW (1992) Mechanism of action of a cytotonic enterotoxin produced by Aeromonas hydrophila. FEMS Microbiol Lett 70(1): 15–19.

    Article  PubMed  CAS  Google Scholar 

  • Chopra AK, Brasier AR, Das M, Xu XJ, Peterson JW (1994) Improved synthesis of Salmonella typhimurium enterotoxin using gene fusion expression systems. Gene 144: 81–85.

    Article  PubMed  CAS  Google Scholar 

  • Chowdhury JR, Novikoff PM, Chowdhury NR, Novikoff AB (1985) Distribution of UDP-glucuronyltransferase in rat tissue. Proc Natl Acad Sci USA 82: 2990–2994.

    Article  PubMed  CAS  Google Scholar 

  • Chu SW, Walker WA (1991) Developmental control of bacterial receptors in the gastrointestinal tract. Microecol Ther 20: 7–21.

    Google Scholar 

  • Chu SW, Walker WA (1993) Bacterial toxin interaction with the developing intestine. Gastroenterology 104: 916–925.

    PubMed  CAS  Google Scholar 

  • Chung KT (1983) The significance of azo reduction in the mutagenesis and carcinogenesis of azo dyes. Mutat Res 114: 269–281.

    Article  PubMed  CAS  Google Scholar 

  • Chung, KT, Cerniglia CE (1992) Mutagenicity of azo dyes: structure-activity relationships. Mutat Res 277: 201–220.

    Article  PubMed  CAS  Google Scholar 

  • Chung KT, Stevens SE Jr (1993) Degradation of azo dyes by environmental microorganisms and the helminths. Environ Toxicol Chem 12: 2121–2132.

    CAS  Google Scholar 

  • Chung KT, Fulk GE, Slein MW (1975) Tryptophanase of fecal flora as a possible factor in the etiology of colon cancer. J Natl Cancer Inst 54: 1073–1078.

    PubMed  CAS  Google Scholar 

  • Chung, KT, Fulk GE, Egan M (1978a) Reduction of azo dyes by the intestinal anaerobes. Appl Environ Microbiol 35: 558–562.

    PubMed  CAS  Google Scholar 

  • Chung KT, Fulk GE, Andrews AW (1978b) The mutagenicity of methyl orange and metabolites produced by intestinal anaerobes. Mutat Res 58: 375–379.

    Article  PubMed  CAS  Google Scholar 

  • Chung KT, Fulk GE, Andrews AW (1981) Mutagenicity testing of some commonly used dyes. Appl Environ Microbiol 42: 641–648.

    PubMed  CAS  Google Scholar 

  • Chung, KT, Stevens SE Jr, Cerniglia CE (1992) The reduction of azo dyes by the intestinal microflora. Crit Rev Microbiol 18: 175–190.

    Article  PubMed  CAS  Google Scholar 

  • Chung KT, Stevens SE Jr, Lin WF, Wei CI (1993) Growth inhibition of selected food-borne bacteria by tannic acid, propyl gallate and related compounds. Lett Appl Microbiol 17: 29–33.

    Article  CAS  Google Scholar 

  • Chung KT, Murdock CA, Stevens SE Jr, et al. (1995) Mutagenicity and toxicity studies of p-phenylenediamine and it derivatives. Toxicol Lett. 81: 23–32.

    Article  PubMed  CAS  Google Scholar 

  • Cole CB, Fuller R, Mallet AK, Rowland IR (1985) The influence of the host on expression of intestinal microbial enzyme activities involved in metabolism of foreign compounds. J Appl Bacteriol 59: 549–553.

    Article  PubMed  CAS  Google Scholar 

  • Combes RD, Haveland-Smith RB (1982) A review of the genotoxicity of food, drug and cosmetic colours and other azo, triphenylmethane and xanthene dyes. Mutat Res 98: 101–248.

    Article  PubMed  CAS  Google Scholar 

  • Combes RD (1989). Cytochrome p-450, mixed function oxidases and formation of genotoxic metabolites by the intestinal tract. In: Koster AS, Richter E, Lauterbach F, Hartmann F., eds. Intestinal Metabolism of Xenobiotics, pp. 119–145. Stuttgart: Gustav Fisher Verlag.

    Google Scholar 

  • Commoner B, Vithayathil AJ, Dolara P, Nair S, Madyastha P, Cuca GC (1978) Formation of mutagens in beef and beef extract during cooking. Science 201: 913–916.

    Article  PubMed  CAS  Google Scholar 

  • Concon JM (1988) Food Toxicology, Part A & B. New York: Mercel Dekker.

    Google Scholar 

  • Conn EE (1981) Unwanted biological substances in foods. In: Ayres J, Kirschman J, eds., Impact of Toxicology on Food Processing, pp. 105–121. Westport, Conn: AVI.

    Google Scholar 

  • Conney AH (1982) Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G.H.A. Clowes Memorial Lecture. Cancer Res 42: 4875–4917.

    PubMed  CAS  Google Scholar 

  • Coon MJ, Ding X, Pernecky SJ, Vaz ADN (1992) Cytochrome P450: progress and predictions. FASEB 6: 669–673.

    CAS  Google Scholar 

  • Crotty B (1994) Ulcerative colitis and xenobiotic metabolism. Lancet 343: 35–38.

    Article  PubMed  CAS  Google Scholar 

  • Cutrecasas P (1973) Gangliosides and membrane receptors for cholera toxin. Biochem 12: 3558–3566.

    Article  Google Scholar 

  • Czeczulin JR, Hanna PC, McClane BA (1993) Cloning, nucleotide sequencing, and expression of Clostridium perfringens enterotoxin gene in Escherichia coli. Infect Immun 61: 3429–3439.

    PubMed  CAS  Google Scholar 

  • D’Aoust JY (1991) Pathogenicity of foodborne Salmonella. Int J Food Microbiol 12: 17–40.

    Article  PubMed  Google Scholar 

  • Dauterman WC (1994) Metabolism of toxicants: phase II reactions. In: Hodgson E, Levi PE, eds., Introduction to Biochemical Toxicology, 2nd ed., pp. 113–132. Norwalk, Conn: Appleton & Lange.

    Google Scholar 

  • Davidson PM (1993) Parabens and phenolic compounds. In: Davidson PM, Branen AL, eds. Antimicrobials in Foods, 2nd ed., pp. 263–306. New York: Marcel Dekker.

    Google Scholar 

  • Dawson J, Bridges JW (1981) Intestinal microsomal drug metabolism: A comparison of rat and guinea-pig enzymes and of rat crypt and villous tip cell enzymes. Biochem Pharmacol 30: 2415–2420.

    Article  PubMed  CAS  Google Scholar 

  • De Meester C (1989) Bacterial mutagenicity of heterocyclic amines found in heat-processed food. Mutat Res 221: 235–262.

    Article  PubMed  Google Scholar 

  • Delclos KB, Cerniglia CE, Dooley KL, Campbell WL, Franklin W, Walker RP (1990) The role of intestinal microflora in the metabolic activation of 6-nitrochrysene to DNA-binding derivatives in mice. Toxicol 60: 137–150.

    Article  CAS  Google Scholar 

  • Delor I, Kaeckenbeeck A, Wauters G, Cornells GR (1990) Nucleotide sequence of yst, the Yersinia enterocoliticca gene encoding the heat-stable enterotoxin, and prevalence of the gene among pathogenic and nonpathogenic yersiniae. Infect Immun 58: 2983–2988.

    PubMed  CAS  Google Scholar 

  • Delor I, Cornells GR (1992) Role of Yersinia enterocolitica Yst toxin in experimental infection of young rabbits. Infect Immun 60: 4269–4277.

    PubMed  CAS  Google Scholar 

  • Depitre C, Delmee M, Avesani V, et al. (1993) Serogroup F strains of Clostridium difficile produce toxin B but not toxin A. J Med Microbiol 38: 434–441.

    Article  PubMed  CAS  Google Scholar 

  • Domagk G (1935) Ein Beitrag zur Chemotherapie der bakteriellen infektionen. Dtsch Med Wochenschr 61: 250–253.

    Article  CAS  Google Scholar 

  • Drasar BS, Barrow PA (1985) Intestinal Microbiology. Washington DC: American Society for Microbiology.

    Google Scholar 

  • Drobniewski FA (1993) Bacillus cereus and related species. Clin Microbiol Rev 6: 324–338.

    PubMed  CAS  Google Scholar 

  • Duimstra JR, Myers LL, Collins JE, Benfield DA, Snoop DS, Bradbury WC (1991) Enterovirulence of enterotoxingenic Bacteroides fragilis in gnotobiotic pigs. Vet Pathol 28: 514–518.

    Article  PubMed  CAS  Google Scholar 

  • El-Bayoumy K, Sharma C, Louis YM, Reddy B, Hecht SS (1983) The role of intestinal microflora in the metabolic reduction of 1-nitropyrene to 1-aminopyrene in conventional and germfree rats and in humans. Cancer Lett 19: 311–316.

    Article  PubMed  CAS  Google Scholar 

  • Elwell L, Shipley PL (1980) Plasmid-mediated factors associated with virulence of bacteria to animals. Annu Rev Microbiol 34: 465–496.

    Article  PubMed  CAS  Google Scholar 

  • Fasano A, Baudry B, Pumplin DW, et al. (1991) Vibrio cholerae produces a second enterotoxin, which affects intestinal tight junction. Proc Natl Acad Sci USA 88: 5242–5246.

    Article  PubMed  CAS  Google Scholar 

  • Felton JS, Knize MG, Shen NH, et al. (1986) The isolation and identification of a new mutagen from fried ground beef: 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine (PhIP). Carcinogenesis 7: 1081–1086.

    Article  PubMed  CAS  Google Scholar 

  • Felton JS, Knize MG (1991) Mutagen formation in muscle meats and model heating systems. In: Hayatsu H, ed. Mutagens in Food: Detection and Prevention, pp. 57–66. Boca Raton, Fla: CRC Press.

    Google Scholar 

  • Fenwick GR, Heaney RK, Mawson R (1989) Glucosinolates. In: Cheeke PR ed., Toxicants of Plant Origin, Vol. II. Glycosides, pp. 2–42. Boca Raton, Fla: CRC Press.

    Google Scholar 

  • Fernandez H, Neto UF, Fernandes F, de Almeida Pedra M, Trabulsi LR (1983) Culture supernatants of Campylobacterjejuni segments of adult rats. Infect Immun 40: 429–431.

    PubMed  CAS  Google Scholar 

  • Field M (1980) Intestinal secretion and its stimulation by enterotoxins. In: Ouchterlony O, Holmgren J, eds. Cholera and Related Diarrheas, pp. 46–52. Basel: Karger.

    Google Scholar 

  • Field M, Rad MC, Chang EB (1989) Intestinal electrolyte transport and diarrheal disease. N Engl J Med 321: 800–806, 879-883.

    Article  PubMed  CAS  Google Scholar 

  • Fletcher DC (1976) Can the quinine in tonic water be hazardous? JAMA 236: 305.

    Google Scholar 

  • Food and Drug Administration (FDA) (1980) FD & C Red No. 2. Denial of petition for permanent listing: final decision. Food and Drug Administration. Federal Register Jan. 25, p. 6252.

    Google Scholar 

  • Fouts JR, Kamm JJ, Brodie BB (1957) Enzymatic reduction of prontosil and other azo dyes. J Pharmacol Exp Ther 120: 291–300.

    PubMed  CAS  Google Scholar 

  • Franz A, Bryant A, Farrant J (1993) Staphylococcal enterotoxin B up-regulates interleukin-2 receptor beta chain expression on tonsillar B cells. Europ J Immunol 23: 2696–2699.

    Article  CAS  Google Scholar 

  • Fu PP, Cerniglia CE, Richardson KE, Heflich RH (1988) Nitroreduction of 6-nitrobenzo(a-)pyrene: a potential activation pathway in humans. Mutat Res 209: 123–129.

    Article  PubMed  CAS  Google Scholar 

  • Fu PP (1990) Metabolism of nitro-polycyclic aromatic hydrocarbons. Drug Metabol Rev 22: 209–268.

    Article  CAS  Google Scholar 

  • Fujii Y, Okamuro Y, Hitotsubashi S, Saito A, Akashi N, Okamoto K (1994) Effect of alterations of basic amino acid residues of Escherichia coli heat-stable enterotoxin II on enterotoxicity. Infect Immun 62: 2295–2301.

    PubMed  CAS  Google Scholar 

  • Fujii-Kuriyama Y, Imataka H, Sogawa K, Yasumoto K-I, Kikuchi Y (1992) Regulation of CYP1A1. FASEB J 6: 706–710.

    PubMed  CAS  Google Scholar 

  • Fuller AT (1937) Is p-aminoazobenzenesulfonamide the active agent in prontosil. Lancet i: 194–198.

    Article  CAS  Google Scholar 

  • Gaitan E (1990) Goitrogens in food and water. Annu Rev Nutr 10: 21–39.

    Article  PubMed  CAS  Google Scholar 

  • George SE, Chadwick RW, Creason JP, Kohan, Dekker JP (1991) Effect of pentachlorophenol on the activation of 2, 6-dintrotoluene to genotoxic urinary metabolites in CD-1 mice: a comparison of GI enzyme activities and urine mutagenicity. Environ Molec Mutagen 18: 92–101.

    Article  CAS  Google Scholar 

  • Gill DM (1976) The arrangement of subunits in cholera toxin. Biochem J 15: 1242–1248.

    Article  CAS  Google Scholar 

  • Gill DM, Meren R (1978) ADP-ribosylation of membrane proteins catalyzed by cholera toxin: basis of the activation of adenylate cyclase. Proc Natl Acad Sci USA 75: 3050–3054.

    Article  PubMed  CAS  Google Scholar 

  • Goldin BR (1986a) The metabolism of the intestinal microflora and its relationship to dietary fat, colon and breast cancer. Prog Clin Biol Res 222: 655–685.

    PubMed  CAS  Google Scholar 

  • Goldin BR (1986b) In situ bacterial metabolism and colon mutagens. Annu Rev Microbiol 40: 367–393.

    Article  PubMed  CAS  Google Scholar 

  • Goldin BR (1990) Intestinal microflora: metabolism of drugs and carcinogens. Ann Med 22: 43048.

    Article  Google Scholar 

  • Goldin BR, Gorbach SL (1984) Alterations of the intestinal microflora by diet, oral antibiotics and lactobacillus: decreased production of free amines from aromatic nitro compounds, azo dyes and glucuronides. J Natl Cancer Inst 73: 689–693.

    PubMed  CAS  Google Scholar 

  • Goldin BR, Peppercorn MA, Goldman P (1973) Contribution of host and intestinal microflora in the metabolism of L-Dopa by the rat. J Pharmacol Exp Ther 186: 160–166.

    PubMed  CAS  Google Scholar 

  • Gorbach SL, Goldin BR (1990) The intestinal microflora and the colon cancer connection. Rev Infect Dis 12: S252–S256.

    Article  PubMed  CAS  Google Scholar 

  • Gosling PJ, Turnbull PC, Lightfoot NF, Pether JV, Lewis RJ (1993) Isolation and purification of Aeromonas sobria cytotonic enterotoxin and ß-haemolysin. J Med Microbiol 38: 227–234.

    Article  PubMed  CAS  Google Scholar 

  • Granum PE, Brynestad S, Kramer JM (1993) Analysis of enterotoxin production by Bacillus cereus from diary products, food poisoning incidents and non-gastrointestinal infections. Int J Food Microbiol 17: 269–279.

    Article  PubMed  CAS  Google Scholar 

  • Gray JI, Dugan LR, Jr., (1975) Inhibition of N-nitrosamine formation in model food systems. J Food Sci 40: 981–984.

    Article  CAS  Google Scholar 

  • Grisebach H, Ebel J (1978) Phytoalexins, chemical defense substances of higher plants? Angew Chem 17: 635–647.

    Article  Google Scholar 

  • Grover S, Batish VK, Srinivasan RA (1990) Production and properties of crude enterotoxin of Pseudomonas aeruginosa. Int J Food Microbiol 10: 201–208.

    Article  PubMed  CAS  Google Scholar 

  • Guaycurus TV, Vicente AC, de Simone SG, Rabinovitch L (1993) Partial isolation and some properties of enterotoxin produced by Bacillus cereus strains. Memorias do Institute Oswald Cruz 88: 131–134.

    Article  CAS  Google Scholar 

  • Guengerich, FP (1992a) Cytochrome P450: advances and prospects. FASEB J 6: 667–668.

    PubMed  CAS  Google Scholar 

  • Guengerich, FP (1992b) Characterization of human cytochrome P450 enzymes. FASEB J 6: 745–748.

    PubMed  CAS  Google Scholar 

  • Gurr MI (1988) Lipids: products of industrial hydrogenation, oxidation and heating. In: Walker R, Quattrucci E, eds. Nutritional and Toxicological Aspects of Food Processing, pp. 139–158. New York: Taylor and Francis.

    Google Scholar 

  • Gyles CL (1992) Escherichia coli cytotoxins and enterotoxins. Can J Microbiol 38: 734–746.

    Article  PubMed  CAS  Google Scholar 

  • Hall BE, James SP (1980) Some pathways of xenobiotic metabolism in the adult and neonatal marmoset (Callithrix jacchus). Xenobiotics 10: 421–434.

    Article  CAS  Google Scholar 

  • Hall S, Reichardt PB (1984) Cryptic paralytic shellfish toxins. In Ragelis EP: Seafood Toxins, p. 113 Washington, DC: American Chemical Society.

    Chapter  Google Scholar 

  • Hanninen O, Lindstrom-Seppa P, Pelkonen K (1987) Role of gut in xenobiotic metabolism. Arch Toxicol 60: 34–36.

    Article  PubMed  CAS  Google Scholar 

  • Hariharan H, Panigrahi D (1990) Cholera-like enterotoxin in certain Campylobacter jejuni strains: some observations. Microbiologica 13: 7–9.

    PubMed  CAS  Google Scholar 

  • Harne SD, Sharma VD, Rahman H (1994) Purification and antigenicity of Salmonella newport enterotoxin. Ind J Medical Research Section A-Infectious Diseases 99: 13–17.

    CAS  Google Scholar 

  • Hatch FT, Felton JS, Stuermer DH, Bjeldanes LF (1984) Identification of mutagens from the cooking of food. In: de Serres, FJ., ed. Chemical Mutagens, Principles and Methods for Their Detection, Vol. 9, p. 111. New York: Plenum Press.

    Google Scholar 

  • Hatch FT, Knize MG, Healy SK, Slezak T, Felton JS (1988) Cooked-food mutagen reference list and index. Environ Mol Mutagen 12(suppl 14): 1–85.

    PubMed  CAS  Google Scholar 

  • Hayashi Y (1991) Cancer risk assessment of food additives and food contaminants. In: Hayatsu H, ed. Mutagens in Food: Detection and Prevention, pp. 243–257. Boca Raton, Fla: CRC Press.

    Google Scholar 

  • Hayes MA, Rushmore TH, Goldberg MT (1987) Inhibition of hepatocarcinogenic responses to 1, 2-dimethylhydrazine by diallyl sulfide, a component of garlic oil. Carcinogenesis 8: 1155–1157.

    Article  PubMed  CAS  Google Scholar 

  • Hegarty MP (1986) Toxic ammo acids in foods of animals and man. Proc Nutr Soc Aust 11: 73–81.

    CAS  Google Scholar 

  • Hiasa Y, Konishi Y, Kamatomo Y, Watanabe T, Ito N (1971) Effect of lithocholic acid by intestinal microflora. J Steroid Biochem 7: 641–647.

    Google Scholar 

  • Hill M (1987) The role of bacteria in human carcinogenesis. Anticancer Res 7: 1079–1084.

    PubMed  CAS  Google Scholar 

  • Hitotsubashi S, Fujii Y, Yamanak H, Okamoto K (1992) Some properties of purified Escherichia coli heat-stable enterotoxin H. Infect Immun 60: 4468–4474.

    PubMed  CAS  Google Scholar 

  • Hodgson E, Levi PE (1994) Metabolism of toxicants phase I reactions. In: Hodgson E, Levi PE, eds. Introduction to Biochemical Toxicology, 2nd Ed., pp. 75–112. Norwalk, Conn: Appleton & Lange.

    Google Scholar 

  • Hodgson E (1994) Chemical and environmental factors affecting metabolism of xenobiotics. In: Hodgson E, Levi PE, eds. Introduction to Biochemical Toxicology, 2nd ed., pp. 153–175. Norwalk, Conn: Appleton & Lange.

    Google Scholar 

  • Hoensch HP, Woo CH, Raffin SB, Schmid R (1976) Oxidative metabolism of foreign compounds in rat small intestine: cellular localization and dependence on dietary iron. Gastroenterology 70: 1063–1070.

    PubMed  CAS  Google Scholar 

  • Hoensch HP, Hartmann F (1981) The intestinal enzymatic biotransformation system: potential role in protection from colon cancer. Hepato-gastroenterol 28: 221–228.

    CAS  Google Scholar 

  • Hoensch HP, Steinhardt HJ, Malchow H (1982) Metabolism of xenobiotica in human small intestinal mucosa, relationship to, carcinogenic factors. In: Malt RA, Williamson RCN, eds. Colonic Carcinogenesis, pp. 83–90. Boston: MTP Press.

    Google Scholar 

  • Hoffmann ML, Jablonski LM, Crum KK, et al. (1994) Predictions of T-cell receptor-and major histocompatibility complex-binding sites on staphylococcal enterotoxin C1. Infect Immun 62: 3396–3407.

    PubMed  CAS  Google Scholar 

  • Hokama Y, Miyahara JT (1986) Ciguatera poisoning: clinical and immunological aspects. J Toxicol Toxin Rev 5: 25–53.

    CAS  Google Scholar 

  • Holmgren J, Lycke N, Czerkinsky C (1993) Cholera toxin and cholera B subunit as oralmucosal adjuvant and antigen vector systems. Vaccine 11: 1179–1184.

    Article  PubMed  CAS  Google Scholar 

  • Howard PC, Beland FA, Cerniglia CE (1983) Reduction of the carcinogen 1-nitropyrene to 1-aminopyrene by rat intestinal bacteria. Carcinogenesis 4: 985–990.

    Article  PubMed  CAS  Google Scholar 

  • Howard PC, Hecht SS, Beland FA (1990) Nitroarenes: Occurrence, Metabolism, and Biological Impact. New York: Plenum Press.

    Google Scholar 

  • Hsieh DPH (1989) Carcinogenic potentials of mycotoxin in foods. In: Taylor SL, Scanlan RA, eds. Food Toxicology: A Perspective on the Relative Risk, pp. 11–30. New York: Marcel Dekker.

    Google Scholar 

  • IFT Expert Panel on Food Safety and Nutrition and the Committee on Public Information (1980) Food Colors. Food Technol 34: 77–84.

    Google Scholar 

  • IFT Expert Panel on Food Safety and Nutrition (1986) Sweeteners: nutritive and nonnutritive. Food Technol 40: 195–206.

    Google Scholar 

  • Ilett KF, Tee LBG, Reeves PT, Minchin RF (1990) Metabolism of drugs and other xenobiotics in the gut lumen and wall. Pharmacol Ther 46: 67–93.

    Article  PubMed  CAS  Google Scholar 

  • Jacobs MM (1983) Selenium inhibition of 1, 2-dimethylhydrazine-induced colon carcinogenesis. Cancer Res 43: 1646–1649.

    PubMed  CAS  Google Scholar 

  • Jagerstad M, Skog K, Grivas S, Olsson K (1991) Formation of heterocyclic amines using model systems. Mutat Res 259: 219–233.

    Article  PubMed  CAS  Google Scholar 

  • Jay JM. (1992) Modern Food Microbiology, 4th ed., pp. 251–289. New York: Van Nostrand Reinhold.

    Book  Google Scholar 

  • Johnson HM, Russell JK, Pontzer CH (1991) Staphylococcal enterotoxin microbial superantigens. FASEB J 5: 2706–2712.

    PubMed  CAS  Google Scholar 

  • Joint Committee of the Royal College of Physicians and the British Nutrition Foundation (1984) Food intolerance and food aversion. J R Coll Physicians Lond 18: 83–123.

    Google Scholar 

  • Joint Expert Committee on Food Additives (JECFA) (1988) L-Glutamic acid and its ammonium, calcium, monosodium and potassium salts. In: Toxicological Evaluation of Certain Food Additives and Contaminants, WHO Series 22, pp. 97–161. New York: Cambridge University Press.

    Google Scholar 

  • Jones JM (1992a) Naturally occurring food toxicants. In: Food Safety, pp. 69–105. St. Paul: Egan Press.

    Google Scholar 

  • Jones JM (1992b) Food additives. In: Food Safety, pp. 203–257. St. Paul: Eagan Press.

    Google Scholar 

  • Kadlubar FF, Hammons GJ (1986) The role of cytochrome P-450 in the metabolism of chemical carcinogens. In: Guengerich FP, ed. Mammalian Cytochrome P-450, Vol. II, pp. 81–130. Boca Raton, Fla: CRC Press.

    Google Scholar 

  • Kamm JJ, Dashman T, Newmark H, Mergens WJ (1977) Inhibition of amine-nitrite hepatoxicity by α-tocopherol. Toxicol Appl Pharmacol 41: 575–583.

    Article  PubMed  CAS  Google Scholar 

  • Kapadia GJ, Chung EB, Ghosh B, et al. (1978) Carcinogenicity of some folk medicinal herbs in rats. J Natl Cancer Inst 60: 683–686.

    PubMed  CAS  Google Scholar 

  • Kasai H, Yamaizumi Z, Wakabayashi K, et al. (1980a) Potent novel mutagens produced by broiling fish under normal conditions. Proc Jpn Acad 56B: 278–283.

    Google Scholar 

  • Kasai H, Yamaizumi Z, Wakabayashi K, et al. (1980b) Structure and chemical synthesis of Me-IQ, a potent mutagen isolated from broiled fish. Chem Lett 1391-1394.

    Google Scholar 

  • Kasai J, Yamaizumi S, Shiomi T, et al. (1981) Structure of a potent mutagen isolated from fried beef. Chem Lett 485-488.

    Google Scholar 

  • Kat M (1983) Dinophysis acuminata blooms in the Dutch coastal area related to diarrhetic mussel poisoning in the Dutch Waddensea. Sarsia 68: 81–84.

    Google Scholar 

  • Kato K, Shirosita K, Kurosawa S, et al. (1990) Staphylococcal enterotoxin A induced interferon (JPN) gamma production in spleen cells from BCG-immunized mice: the IFN production is dependent on leukotriene C4 but not dependent on interleukin 2. Immunology 18: 40–50.

    Google Scholar 

  • Khurana S, Ganguly NK, Khullar M, Panigrahi D, Walia BN (1991) Studies on the mechanism of Salmonella typhimurium enterotoxin-induced diarrhea. Biochim Biophys Acta 1097: 171–176.

    Article  PubMed  CAS  Google Scholar 

  • King LC, Kohan MJ, George SE, Lewtas J, Claxton LD (1990) Metabolism of 1-nitropyrene by human, rat and mouse intestinal flora: mutagenicity of isolated metabolites by direct analysis of HPLC fractions with a micro-suspension reverse mutation assay. J Toxicol Environ Health 31: 179–192.

    Article  PubMed  CAS  Google Scholar 

  • Kinouchi T, Ohnishi Y (1986) Metabolic activation of 1-nitropyrene and 1, 6-dinitropyrene by nitroreductases from Bacteroides fragilis and distribution of nitroreductase activity in rats. Microbiol Immunol 30: 979–992.

    PubMed  CAS  Google Scholar 

  • Kita E, Oku D, Hamuro A, et al. (1990) Hepatotoxic activity of Campylobacter jejuni. J Med Microbiol 33: 171–182.

    Article  PubMed  CAS  Google Scholar 

  • Klipstein FA, Engert RF (1977) Immunological interrelationships between cholera toxin and the heat-labile and heat-stable enterotoxins of coliform bacteria. Infect Immun 18: 110–117.

    PubMed  CAS  Google Scholar 

  • Klipstein FA, Engert RF (1985) Immunological relationship of the B subunits of Campylobacter jejuni and Escherichia coli heat-labile enterotoxins. Infect Immun 48: 629–633.

    PubMed  CAS  Google Scholar 

  • Koop DR (1992) Oxidative and reductive metabolism by cytochrome P450 2E1. FASEB J 6: 724–730.

    PubMed  CAS  Google Scholar 

  • Koster ASJ, Frankhuizen-Sierevogel AC, Noordhoek (1985) Distribution of glucuronidation capacity (1-naphthol and morphine) along the rat intestine. Biochem Pharmacol 34: 3527–3532.

    Article  PubMed  CAS  Google Scholar 

  • Krone CA, Yeh SMJ, Iwaoka WT (1986) Mutagen formation during commercial processing of foods. Environ Health Perspect 67: 75–88.

    Article  PubMed  CAS  Google Scholar 

  • Kwok RHM (1968) Chinese restaurant syndrome. N Engl J Med 278: 796.

    Google Scholar 

  • Labbe RG, Rey DK (1979) Raffinose increases sporulation and enterotoxin production by Clostridium perfringens type A. Appl Environ Microbiol 37: 1196–1200.

    PubMed  CAS  Google Scholar 

  • Labbe RG, Nolan LL (1981) Stimulation of Clostridium perfringens enterotoxin formation by caffeine and theobromine. Infect Immun 34: 50–54.

    PubMed  CAS  Google Scholar 

  • Laitinen M, Watkins JB (1986) Mucosal biotransformations. In: Rozman K, Hanninen O, eds. Gastrointestinal Toxicology, pp. 412–434. Amsterdam: Elsevier Science.

    Google Scholar 

  • Lathe R, Hirth P, Dewide M, Harford N, Lecocq J-P (1980) Cell-free synthesis of enterotoxin of E. coli from a cloned gene. Nature 284: 473–474.

    Article  PubMed  CAS  Google Scholar 

  • Lathia D, Braasch A, Theissen U (1988) Inhibitory effects of vitamin C and E on in-vitro formation of N-nitrosamine under physiological conditions. Front Gastrointest Res 14: 151–156.

    CAS  Google Scholar 

  • Lauritsen K, Hansen J, Ryde M, Rask-Madsen J (1984) Colonic azo disalicylate metabolism determined by in vivo dialysis in healthy volunteers and patients with ulcerative colitis. Gastroenterology 86: 1496–1500.

    PubMed  CAS  Google Scholar 

  • Lee CH, Moseley SL, Moon HW, Whipp SC, Gyles CL, So M (1983) Characterization of the gene encoding heat stable toxin 2 and preliminary studies of enterotoxigenic Escherichia coli heat stable toxin 2 producers. Infect Immun 42: 264–268.

    PubMed  CAS  Google Scholar 

  • Legraverend C, Mode A, Wells T. Robinson I, Gustafsson J-A (1992) Hepatic steroid hydroxylating enzymes are controlled by the sexually dimorphic pattern of growth hormone secretion in normal and dwarf rats. FASEB J 6: 711–718.

    PubMed  CAS  Google Scholar 

  • Leiner IE (1980) Toxic Constituents of Plant Foodstuffs. New York: Academic Press.

    Google Scholar 

  • Leiner IE (1981) The nutritional significance of the plant lectins. In: Ory RL, ed. Antinutrients, Natural Toxicants in Foods, pp. 143–158. Westport, Conn: F & N Press.

    Google Scholar 

  • Leonard TB, Graichen ME, Popp JA (1987) Dinitrotoluene isomer-specific hepatocarcinogenesis in F344 rats. J Natl Cancer Inst 79: 1313–1319.

    PubMed  CAS  Google Scholar 

  • Levi PE (1994) Reactive metabolites and toxicity. In: Hodgson E, Levi PE, eds. Introduction to Biochemical Toxicology, 2nd ed., pp. 219–239. Norwalk, Conn: Appleton & Lange.

    Google Scholar 

  • Levine WG (1991) Metabolism of azo dyes: implication for detoxication and activation. Drug Metab Rev 23: 253–309.

    Article  PubMed  CAS  Google Scholar 

  • Lindenbaum J, Rund DL, Butler VP, Tse-Eng D, Saka J (1981) Inactivation of digoxin by the gut flora: reversed by antibiotic therapy. N Engl J Med 305: 789–794.

    Article  PubMed  CAS  Google Scholar 

  • Loub WD, Wattenberg LW, Davis DW (1975) Aryl hydrocarbon hydroxylase induction in rat tissues by naturally occuring indoles of cruciferous plants. J Natl Cancer Inst 54: 985–987.

    PubMed  CAS  Google Scholar 

  • MacDonald IA, Bussard RG, Hutchison DM, Holdeman LV (1984) Rutin-induced ß-glucosidase activity in Streptococcus faecium VGH-1 and Streptococcus sp. strain FRP-17 isolated from human feces: formation of the mutagen, quercetin, from rutin. Appl Environ Microbiol 47: 350–355.

    PubMed  CAS  Google Scholar 

  • MacGregor JT, Jurd JL (1978) Mutagenicity of plant flavonoids: structural requirements for mutagenic activity in Salmonella typhimurium. Mutat Res 54: 297–309.

    Article  PubMed  CAS  Google Scholar 

  • MacGregor JT (1986a) Genetic toxicology of dietary flavonoids. In: Genetic Toxicology of the Diet, pp. 33–43. New York: Alan R. Liss.

    Google Scholar 

  • MacGregor JT (1986b) Mutagenic and carcinogenic effects of flavonoids. In: Plant Flavonoids in Biology and Medicine, pp. 411–424, New York: Alan R. Liss.

    Google Scholar 

  • Mahajan S, Rodgers FG (1990) Isolation, characterization, and host-cell-binding properties of a cytotoxin from Campylobacter jejuni. J Clin Microbiol 28: 1313–1320.

    Google Scholar 

  • Majeed KN, Egan AF, Mac Rae IC (1990) Production of exotoxins by Aeromonas spp. at 5 degrees C. J Appl Bacteriol 69: 332–337.

    Article  PubMed  CAS  Google Scholar 

  • Malaspina A (1987) Regulatory aspects of food additives. In: Miller K, ed. Toxicological Aspects of Food, pp. 17–58. New York: Elsevier.

    Google Scholar 

  • Mallett AK, Rowland IR (1990) Bacterial enzymes: their role in the formation of mutagens and carcinogens in the intestine. Dig Dis 8: 71–79.

    Article  PubMed  CAS  Google Scholar 

  • Manning BW, Cerniglia CE, Federle TW (1986) Biotransformation of 1-nitropyrene to 1-aminopyrene and 1-formyl-1-aminopyrene by the human intestinal microbiota. J Toxicol Environ Health 18: 339–346.

    Article  PubMed  CAS  Google Scholar 

  • Marquardt RR (1989) Vicine, convicine and their aglycones — derivatives and isouramil. In: Cheeke PR, ed. Toxicants of Plant Origin, Vol. 2, Glycosides, pp. 161–200. Boca Raton, Fla: CRC Press.

    Google Scholar 

  • Mastromarino A, Reddy BS, Wynder EL (1976) Metabolic epidemiology of colon cancer: enzymatic activity of fecal flora. Am J Clin Nutr 29: 1455–1460.

    PubMed  CAS  Google Scholar 

  • Mastromarino A, Reddy BS, Wynder EL (1978) Fecal profiles of anaerobic microflora of large bowel cancer patients with nonhereditary large bowel polyps. Cancer Res 38: 4458–4462.

    PubMed  CAS  Google Scholar 

  • Matsumoto Y, Fujiwara M (1993) Immunomodulation of experimental autoimmune encephalomyelitis by staphylococcal enterotoxin D. Cell Immunol 149: 268–278.

    Article  PubMed  CAS  Google Scholar 

  • McCabe BJ (1986) Dietary tyramine and other pressor amines in MAOI regimens: a review. J Am Diet Assoc 86: 1059–1064.

    PubMed  CAS  Google Scholar 

  • McCalla DR (1983) Mutagenicity of nitrofuran derivatives. Environ Mutagen 5: 745–765.

    Article  PubMed  CAS  Google Scholar 

  • McClane BA (1994) Clostridium perfringens enterotoxin acts by producing small molecular permeability alterations in plasma membranes. Toxicology 87: 43–67.

    Article  PubMed  CAS  Google Scholar 

  • McCoy EC, Petrillo LA, Rosenkranz HS (1979) The demonstration of cooperative action and intestinal mucosa enzymes in the activation of mutagens. Biochem Biophys Res Commun 89: 859–862.

    Article  PubMed  CAS  Google Scholar 

  • McCoy EC, Rosenkranz HS, Mermelstein (1981) Evidence for the existence of a family of bacterial nitroreductases capable of activating nitrated polycyclics to mutagens. Environ Mutagen 3: 421–427.

    Article  PubMed  CAS  Google Scholar 

  • McKay JA, Murray GI, Weaver RJ, Ewen SWB, Melvin WT, Burke MD (1993) Xenobiotic metabolizing enzyme expression in colonic neoplasia. Gut 34: 1234–1239.

    Article  PubMed  CAS  Google Scholar 

  • Mehansho H, Butler LG, Carlson DM (1987) Dietary tannins and salivary proline-rich proteins. Annu Rev Nutr 7: 423–440.

    Article  PubMed  CAS  Google Scholar 

  • Mekalanos JJ (1983) Duplication and amplification of toxin genes in Vibrio cholerae. Cell 35: 253–263.

    Article  PubMed  CAS  Google Scholar 

  • Mekalanos JJ (1985) Cholera toxin: genetic analysis, regulation, and role in pathogenesis. Curr Top Microbiol Immunol 118: 97–118.

    Article  PubMed  CAS  Google Scholar 

  • Mekalanos JJ, Swartz DJ, Pearson GDN, Hartford N, Groyne F, de Wilde M (1983) Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development. Nature 306: 551–557.

    Article  PubMed  CAS  Google Scholar 

  • Mekalanos J, Goldberg I, Miller V, et al. (1985) Genetic construction of cholera vaccine prototypes. In: Lerner RA, Chanock RM, Brown F, eds. Vaccines 85, pp. 101–105. Cold Spring Harbor, NY: Cold Spring Harbor Press.

    Google Scholar 

  • Merz B (1983) Adding seeds to the diet may keep cancer at bay. JAMA 249: 2746.

    Article  PubMed  CAS  Google Scholar 

  • Mezoff AG, Giannella RA, Eade MN, Cohen MB (1992) Escherichia coli enterotoxin (STa) binds to receptors, stimulates guanyl cyclase, and impairs absorption in rat colon. Gastroenterology 102: 816–822.

    PubMed  CAS  Google Scholar 

  • Middlebrook JL, Dorland RB (1984) Bacterial toxins: cellular mechanisms of action. Microbiol Rev 47: 596–620.

    Google Scholar 

  • Mikami T, Horikawa T, Murakami T, et al. (1994) An improved method for detecting cytostatic toxin (emetic toxin) of Bacillus cereus and its application to food samples. FEMS Microbiol Lett 119: 53–57.

    Article  PubMed  CAS  Google Scholar 

  • Miller DM, Dickey RW, Tindall DR (1984) Lipid-extracted toxins from a dinoflagellate, Gambierdiscus toxicus. In: Ragelis EP, ed. Seafood Toxins. Washington, DC: American Chemical Society.

    Google Scholar 

  • Miller EC, Miller JA (1986) Carcinogens and mutagens that occur in foods. Cancer 58: 1795–1803.

    Article  PubMed  CAS  Google Scholar 

  • Miller JA, Baumann CA (1945) The carcinogenicity of certain azo dyes related to p-dimethylaminoazobenzene. Cancer Res 5: 227–234.

    CAS  Google Scholar 

  • Miller JA, Miller EA (1948) Carcinogenicity of certain derivatives of p-dimethylaminoazobenzene in rat. J Exp Med 87: 139–156.

    Article  PubMed  CAS  Google Scholar 

  • Miller JA, Miller EA, Phillips DH (1982) The metabolic activation and carcinogenicity of alkenylbenzenes that occur naturally in many spices. In: Stich HF, ed. Carcinogens and Mutagens in the Environment, Vol. 3, pp. 83–96. Boca Raton, Fla: CRC Press.

    Google Scholar 

  • Millstone E (1985) Food additives: the balance of risks and benefits. Chem Indust 21: 421–442.

    Google Scholar 

  • Milner JA (1985) Dietary antioxidants and cancer. Contemp Nutr 10: 1–2.

    Google Scholar 

  • Mizutani T, Mitsuoka T (1981) Relationship between liver tumorigenesis and intestinal bacteria in gnotobiotic C3H/He male mice. In: Sasaki S, ed. Recent Advances in Germfree Research, pp. 639–644. Tokyo: Tokai University Press.

    Google Scholar 

  • Morgan MRA, Coxon DT (1987) Tolerances: Glycoalkaloids in Potatoes. In: Watson DH, ed. Natural Toxicants in Foods: Progress and Prospects, pp. 221–230. New York: DCH Publishers.

    Google Scholar 

  • Morris CE, Przybyla A (1985) Cyclamate. Special report. Chilton’s Food Eng Int 57: 67–75.

    Google Scholar 

  • Murdoch RD, Pollock I, Naeem S (1987) Tartrazine induced histamine release in vivo in normal subjects. J R Coll Phys Lond 21: 257–261.

    CAS  Google Scholar 

  • Nagao M, Honda M, Seino Y, Yahagi T, Sugimura T (1977a) Mutagenicity of smoke condensates and the charred surface of fish and meat. Cancer Lett 2: 221–226.

    Article  PubMed  CAS  Google Scholar 

  • Nagao M, Honda M, Seino Y, Yahagi T, Kawachi T, Sugimura T (1977b) Mutagenicities of protein pyrolysates. Cancer Lett 2: 335–340.

    Article  PubMed  CAS  Google Scholar 

  • Nagao M, Wakabayaski F, Fujita Y, Tahura A, Ochrai T, Sugimura T (1986) Mutagenic compounds in soy sauce, Chinese cabbage, coffee and herbal teas. In: Genetic Toxicology of the Diet, pp. 55–62. New York: Alan R. Liss.

    Google Scholar 

  • Narisawa T, Magadia NE, Weisburger JH, Wynder EL (1974) Promoting effect of bile acids on colon carcinogenesis after intrarectal instillation of N-methyl-N′-nitro-N-nitro-soguanidine in rats. J Natl Cancer Inst 53: 1093–1097.

    PubMed  CAS  Google Scholar 

  • NAS/NRC (1989) Diet and Health: Implications for Reducing Chronic Disease Risk. Washington, DC: National Academy Press.

    Google Scholar 

  • Nebert DW, Gonzalez FJ (1987) P450 genes: structure, evolution, and regulation. Annu Rev Biochem 56: 945–993.

    Article  PubMed  CAS  Google Scholar 

  • Nebert DW, Adesnik M, Coon MJ, et al. (1987) The p450 gene superfamily: recommended nomenclature. DNA 6: 1–11.

    Article  PubMed  CAS  Google Scholar 

  • Negishi C, Wakabayashi K, Tsuda M, et al. (1984) Formation of 2-amino-3, 7, 8-trimethylimidazo [4, 5-f]quinoxaline, a new mutagen, by heating a mixture of creatine, glucose and glycine. Mutat Res 140: 55–59.

    Article  PubMed  CAS  Google Scholar 

  • Negishi C, Wakabayashi K, Yamaizumi Z, et al. (1985) Identification of 4, 8-DimeIQx, a new mutagen. Selected abstracts of papers presented at the 13th annual meeting of the Environmental Mutagen Society of Japan, Oct. 12-13, 1984. Tokyo. Mutat Res 147: 267–268.

    Article  Google Scholar 

  • Negishi T, Nagao M, Hiramoto K, Hayatsu H (1991a) A list of mutagenic heterocyclic amines. In: Hayatsu H, ed. Mutagens in Food: Detection and Prevention, pp. 7–19. Boca Raton, Fla: CRC Press.

    Google Scholar 

  • Negishi, K, Nagao M, Hiramoto K, Hayatsu H (1991b). DNA modification in vitro and in vivo with heterocyclic amines. In: Hayatsu H, ed. Mutagens in Food: Detection and Prevention, pp. 21–27. Boca Raton, Ha: CRC Press.

    Google Scholar 

  • Nelson RL (1984) Is the changing pattern of colorectal cancer caused by selenium deficiency? Dis Col Rect 27: 459–461.

    Article  CAS  Google Scholar 

  • Newaz SN, Fang WF, Strobel HW (1983) Metabolism of the carcinogens 1, 2-dimethylhy-drazine by isolated human colon microsomes and human colon tumors cells in culture. Cancer 52: 794–798.

    Article  PubMed  CAS  Google Scholar 

  • Newland JW, Strockbine NA, Miller SF, O’Brian AD, Holmes RK (1985) Cloning of Shiga-like toxin structural genes from a toxin converting phage of Escherichia coli. Science 230: 179–181.

    Article  PubMed  CAS  Google Scholar 

  • Ni YC, Heflich RH, Kadlubar FF, Fu PP (1987) Mutagenicity of nitrofurans in Salmonella typhimurium TA98, TA98NR and TA98/1, 8-DNP6. Mutat Res 192: 15–22.

    Article  PubMed  CAS  Google Scholar 

  • Nishio Y, Kakizoe T, Ohtani M, Sato S, Sugimura T, Fukushima. S (1986) Leucine and isoleucine promote bladder cancer. Science 231: 843–845.

    Article  PubMed  CAS  Google Scholar 

  • O’Brien AD, LaVeck GD (1983) Purification and characterization of Shigella dysenteriae 1-like toxin produced by Escherichia coli. Infect Immun 40: 675–683.

    PubMed  Google Scholar 

  • Ohshima H, Bartsch H (1983) A new approach to quantitate endogenous nitrosation in humans. In: Stich HF, ed. Carcinogens and Mutagens in the Environment, Vol. 2, pp. 3–15. Boca Raton, Fla: CRC Press.

    Google Scholar 

  • Olive PL, McCalla DR (1977) Cytotoxicity and DNA damage to mammalian cells by nitrofurans. Chem Biol Interact 16: 223–233.

    Article  PubMed  CAS  Google Scholar 

  • Pamukcu AM, Yaliner S, Hatcher JF, Bryan GT (1980) Quercetin, a rat intestinal and bladder carcinogen present in bracken fern Pteridium equilinum. Cancer Res 40: 3468–3472.

    PubMed  CAS  Google Scholar 

  • Pearson GDN, Mekalanos JJ (1982) Molecular cloning of Vibrio cholerae enterotoxin genes in Escherichia coli K-12. Proc Natl Acad Sci USA 79: 2976–2980.

    Article  PubMed  CAS  Google Scholar 

  • Peppercorn MA, Goldman P (1972) The role of intestinal bacteria in the metabolism of salicylazosulfapyridine. J Pharmacol Exp Ther 181: 555–562.

    PubMed  CAS  Google Scholar 

  • Peppercorn MA, Goldman P (1973) Distribution studies of salicylazosulfapyridine and its metabolites. Gastroenterology 64: 240–245.

    PubMed  CAS  Google Scholar 

  • Perez JL, Berrocal CI, Berrocal L (1986) Evaluation of a commercial ß-glucuronidase test for the rapid and economical identification of Escherichia coli. J Appl Bacteriol 61: 541–545.

    Article  PubMed  CAS  Google Scholar 

  • Pickens RN, Mazaitis AJ, Maas WK, Rey M, Heyneker H (1983) Nucleotide sequence of the gene for heat-stable enterotoxin II of Escherichia coli. Infect Immun 42: 269–275.

    Google Scholar 

  • Powrie WD, Wu CH, Molund VP (1986) Browning reaction systems as sources of mutagens and antimutagens. Environ Health Perspect 67: 47–54.

    Article  PubMed  CAS  Google Scholar 

  • Price JM, Biava CG, Oser BL, Vogin EE, Seinfeld J, Ley HL (1970) Bladder tumors in rats fed cyclohexamine or high doses of a mixture of cyclamate and saccharin. Science 167: 1131–1132.

    Article  PubMed  CAS  Google Scholar 

  • Privai MJ, Davis VM, Peiperl MD, Bell SJ (1988) Evaluation of azo dyes for mutagenicity and inhibition of mutagenicity by methods using Salmonella typhimurium. Mutat Res 206: 247–256.

    Article  Google Scholar 

  • Prosaska HJ, Santamaria AB, Talalay P (1992) Rapid detection of inducers of enzymes that protect against carcinogens. Proc Natl Acad Sci USA 89: 2394–2398.

    Article  Google Scholar 

  • Pryor WA (1985) Free radical involvement in chronic diseases and aging. In: Fenley JW, Schwass DE, eds. Xenobiotics in Foods and Feeds, ACS Symposium 234, pp. 77–96. Washington, DC: American Chemical Society.

    Google Scholar 

  • Rackie JJ, Gumbmann MR (1981) Protease inhibitors: physiological properties and nutritional significance. In: Ory RL, ed. Antinutrients and Natural Toxicants in Foods, pp. 203–237. Westport, Conn: F & N Press.

    Google Scholar 

  • Rafii F, Franklin W, Cerniglia CE (1990) Azoreductase activity of anaerobic bacteria isolated from human intestinal microflora. Appl Environ Microbiol 56: 2146–2151.

    PubMed  CAS  Google Scholar 

  • Rafii F, Franklin W, Heflich RH, Cerniglia CE (1991) Reduction of nitroaromatic compounds by anaerobic bacteria isolated from the human gastrointestinal tract. Appl Environ Microbiol 57: 962–968.

    CAS  Google Scholar 

  • Ranelli DM, Jones CL, Johns MB, Mussey GJ, Khan SA (1985) Molecular cloning of staphylococcal enterotoxin B gene in Escherichia coli and Staphylococcus aureus. Proc Natl Acad Sci USA 82: 5850–5854.

    Article  PubMed  CAS  Google Scholar 

  • Rao MC, Orellana SA, Field M, Robertson DC, Giannella RA (1981) Comparison of the biological actions of three purified heat-stable enterotoxins: effect on ion transport and guanylate cyclase activity in rabbit ileum in vitro. Infect Immun 33: 167–170.

    Google Scholar 

  • Reda KB, Kapur V, Mollick JA, Lamphear JG, Musser JM, Rich RR (1994) Molecular characterization and phylogenetic distribution of the streptococcal superantigen gene (ssa) from Streptococcus pyogenes. Infect Immun 62: 1867–1874.

    PubMed  CAS  Google Scholar 

  • Reed PI, Johnston BJ, Walters CL, Hill MJ (1989) Effect of ascorbic acid on the intragastric environment in patients at increased risk of developing gastric cancer. Gastroenterology 96: A411.

    Google Scholar 

  • Renwick AG, Williams RT (1972) The fate of cyclamate in man and other species. Biochem J 129: 869–879.

    PubMed  CAS  Google Scholar 

  • Rickert DE, Butterworth BE, Popp JA (1984) Dinitrotoluene: acute toxicity, oncogenicity, genotoxicity, and metabolism. CRC Crit Rev Toxicol 13: 217–234.

    Article  CAS  Google Scholar 

  • Rickert DE (1987) Metabolism of nitroaromatic compounds. Drug Metab Rev 18: 23–53.

    Article  PubMed  CAS  Google Scholar 

  • Rolls BA, Turvey A, Coates ME (1978) The influence of the gut microflora and dietary fiber on epithelial cell migration in the chick intestine. Br J Nutr 39: 91–98.

    Article  PubMed  CAS  Google Scholar 

  • Rosenkranz HS, McCoy EC, Mermelstein R, Speck WT (1981) A cautionary note on the use of nitro-reductase-deficient strains of Salmonella typhimurium for the detection of nitroarenes as mutagens in complex mixture including diesel exhaust. Mutat Res 91: 103–105.

    Article  PubMed  CAS  Google Scholar 

  • Rowland IR, Mallett AK, Cole CB, Fuller R (1987) Mutagen activation by hepatic fractions from conventional germfree and monoassociated rats. Arch Toxicol (suppl)11: 261–263.

    CAS  Google Scholar 

  • Roy MP, Spencer PS (1989) Lathrogen. In: Cheeke PR, ed. Toxicants of Plant Origin, Vol. 3. Protein and Amino Acids, pp. 169–202. Boca Raton, Fla: CRC Press.

    Google Scholar 

  • Rudali G, Coezy E, Muranyi-Kovacs I (1969) Research on the carcinogenic effect of sodium cyclamate in the mouse. C R Hebd Seances Acad Sci Ser D 269: 1910–1912.

    CAS  Google Scholar 

  • Ryan CA, Hass GM (1981) Structural, evolutionary and nutritional properties of proteinase inhibitors from potatoes. In: Ory RL, ed. Antinutrients and Natural Toxicants in Foods, pp. 169–185. Westport, Conn: F & N Press.

    Google Scholar 

  • Sandforth F, Gutschmidt (1984) The intestinal monoxygenase enzyme in DMH-induced rat colonic carcinogenesis. Z Gastroenterol 22: 586–591.

    PubMed  CAS  Google Scholar 

  • Schaumburg HH, Byck R, Gerstl R, Mashman JH (1969) Monosodium glutamate: its pharmacology and role in the Chinese restaurant syndrome. Science 163: 826–828.

    Article  PubMed  CAS  Google Scholar 

  • Scheline RR (1973) Metabolism of foreign compounds by gastrointestinal microorganisms. Pharmacol Rev 25: 451–523.

    PubMed  CAS  Google Scholar 

  • Schroder H, Gustafsson BH (1973) Azo reduction of salicylazosulphapyridine in germfree and conventional rats. Xenobiotics 3: 225–231.

    Article  CAS  Google Scholar 

  • Seitz HK (1985) Ethanol and carcinogenesis. In: Seitz HK, Kommerell B, eds. Alcohol Related Diseases in Gastroenterology, pp. 195–212. Berlin: Springer Verlag.

    Chapter  Google Scholar 

  • Seitz HK, Bosche J, Czygan P, Veith S, Kommerell B (1982) Microsomal ethanol oxidation in the colonie mucosa of the rat: effect of chronic ethanol ingestion. Naunyn-Schmiedebergs Arch Pharmacol 320: 81–84.

    Article  PubMed  CAS  Google Scholar 

  • Sela MN, Steinberg D (1989) Glycyrrhizin: the basic facts plus medical and dental benefits. In: Grenby TH, ed. Progess in Sweeteners, pp. 71–79. New York: Elsevier.

    Google Scholar 

  • Settipane GA (1986) The restaurant syndromes. Arch Intern Med 146: 2129–2130.

    Article  PubMed  CAS  Google Scholar 

  • Sharma RP, Salunke DK (1989) Solanum glycoalkaloids. In: Cheeke PR, ed. Toxicants of Plant Origins, Vol. 1. Alkaloids, pp. 179–236. Boca Raton, Fla: CRC Press.

    Google Scholar 

  • Sharma VD, Singh SP, Taku A (1992) Purification of Salmonella Stanley enterotoxin and its immunology and dermatology. Ind J Exp Biol 30: 23–25.

    CAS  Google Scholar 

  • Sherwin ER (1990) Antioxidants. In: Branen AL, Davidson PM, Salminen S, eds. Food Additives, pp. 139–193. New York: Marcel Dekker.

    Google Scholar 

  • Shibamoto T, Bjeldanes LF (1993a) Natural toxins in animal foodstuffs. In: Introduction to Food Toxicology, pp. 43–66. San Diego: Academic Press.

    Google Scholar 

  • Shibamoto T, Bjeldanes LF (1993b) Natural toxins in plantstuffs. In: Introduction to Food Toxicology, pp. 67–96. San Diego: Academic Press.

    Chapter  Google Scholar 

  • Shibamoto T, Bjeldanes LF (1993c). Toxicants formed during food processing. In: Introduction to Food Toxicology, pp. 184–198. San Diego: Academic Press.

    Google Scholar 

  • Shibamoto T, Bjeldanes LF. (1993d) Food additives. In: Introduction to Food Toxicology, pp. 157–182. San Diego: Academic Press.

    Chapter  Google Scholar 

  • Shibamoto T, Bjeldanes LF (1993e) Biotransformation. In: Introduction to Food Toxicology, pp. 35–48. San Diego: Academic Press.

    Chapter  Google Scholar 

  • Shibamoto T, Bjeldanes LF (1993f) Pesticides residues in foods. In: Introduction to Food Toxicology, pp. 141–156. San Diego: Academic Press.

    Chapter  Google Scholar 

  • Shriniwas UM, Bhujwala RA (1979) Production of permeability factor and enterotoxin by Pseudomonas aeruginosa. Ind J Med Res 70: 380–383.

    CAS  Google Scholar 

  • Siegers CP, Bubinger I, Lemoine R, Herbst EW, Younes M (1986) Is alcohol a cocarcinogen in dimethylhydrazine-induced colon tumours in rats? Naunyn-Schmiedebergs Arch Pharmacol 334(suppl): R21.

    Google Scholar 

  • Silverstone GA (1985) Possible sources of food toxicants. In: Seely S, Freed DL, Silverstone GA, Rippere V, eds. Diet-Related Diseases: The Modern Epidemic, pp. 44–60. Westport, Conn: AVI.

    Google Scholar 

  • Sjovall J (1960) Bile acids in man under normal and pathological conditions: bile acids and steroids. Clin Chim Acta 5: 33–41.

    Article  CAS  Google Scholar 

  • Smith GH, Tong TG (1975) Ulcerative colitis. J Am Pharm Assoc NS15: 202–212.

    Google Scholar 

  • Smith HR (1984) Genetics of enterotoxin production in Escherichia coli. Biochem Soc Trans 12: 905–915.

    Google Scholar 

  • Smith HW, Green P, Parsell Z (1983) Vero cell toxins in Escherichia coli and related bacteria: transfer by phage and conjugation and toxic action in laboratory animals, chickens and pigs. J Gen Microbiol 129: 3121–3127.

    PubMed  CAS  Google Scholar 

  • Smith-Barbaro PA, Hanson D, Reddy BS (1981a) Effect of fat and microflora on hepatic, small intestinal and colonic HMG CoA reductase, cytochrome P450 and cytochrome b 5. Lipids 16: 183–188.

    Article  PubMed  CAS  Google Scholar 

  • Smith-Barbaro PA, Hanson D, Reddy BS (1981b) Effect of bran and citrus pulp on hepatic, small intestinal and colonic HMG CoA reductase, cytochrome P-450 and cytochrome b 5. J Nutr 111: 789–797.

    PubMed  CAS  Google Scholar 

  • Sparnins VL, Barany G, Wattenberg LW (1988) Effects of organosulfur compounds from garlic and onion on benzo(a)pyrene-induced neoplasia and glutathione S-transferase activity in the mouse. Carcinogenesis 9: 131–134.

    Article  PubMed  CAS  Google Scholar 

  • Spicer EK, Noble JA (1982) Escherichia coli heat-labile enterotoxin nucleotide sequence of the A subunit gene. J Biol Chem 257: 5716–5721.

    PubMed  CAS  Google Scholar 

  • Stark RL, Duncan CL (1971) Biological characteristics of Clostridium perfringens type A enterotoxin. Infect Immun 4: 89–96.

    PubMed  CAS  Google Scholar 

  • Stephen AM, Cummings JH (1980) The microbial contribution to human faecal mass. J Med Microbiol 13: 45–56.

    Article  PubMed  CAS  Google Scholar 

  • Stich HF, Rosin MP, Bryan L (1982) Inhibition of mutagenicity of a model nitrosation reaction by naturally occurring phenolics, coffee and tea. Mutat Res 95: 119–128.

    Article  PubMed  CAS  Google Scholar 

  • Stoltz DR (1982) The health significance of mutagens in foods. In: Stich HF, ed. Carcinogens and Mutagens in the Environment, Vol. 3, pp. 75–82. Boca Raton, Fla: CRC Press.

    Google Scholar 

  • Streatfield SJ, Sandkvist M, Sixma TK, Bagdasarian M, Hol WG, Hirst TR (1992) Intermolecular interactions between the A and B subunits of heat-labile enterotoxin from Escherichia coli promote holotoxin assembly and stability in vivo. Proc Natl Acad Sci USA 89: 12140–12149.

    Article  PubMed  CAS  Google Scholar 

  • Strobel HW, Fang WF (1981) Role of cytochrome P-450 in the response of the colon to xenobiotics. In: Bruce WR, et al., eds. Gastrointestinal Cancer-Endogenous Factors, Banbury Report No. 7, pp. 141–149. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.

    Google Scholar 

  • Strobel HW, Newaz SN, Fang HF, Lau PP, Oshinsky RJ, Stralka DJ, and Salley FF (1983) Evidence for the presence and reactivity of multiple forms of cytochrome P450 in colonic microsomes from rats and humans. In: Rydstrom J, Montelius J, Bengtsson M, eds. Extrahepatic Metabolism and Chemical Carcinogenesis, pp. 57–66. Amsterdam: Elsevier.

    Google Scholar 

  • Sugarman B, Epps LR (1984) Zinc and the heat-labile enterotoxin of Escherichia coli. J Med Microbiol 18: 393–398.

    Article  PubMed  CAS  Google Scholar 

  • Sugimura T (1985) Carcinogenicity of mutagenic heterocyclic amines formed during the cooking process. Mutat Res 150: 33–44.

    Article  PubMed  CAS  Google Scholar 

  • Sugimura T (1986a) Past, present and future of mutagens in cooked food. Environ Health Perspect 67: 5–10.

    Article  PubMed  CAS  Google Scholar 

  • Sugimura T (1986b) Studies on environmental chemical carcinogenesis in Japan. Science 233: 312–318.

    Article  PubMed  CAS  Google Scholar 

  • Sugimura T, Kawachi T, Nagao M, et al. (1977) Mutagenic principle(s) in tryptophan and phenylalanine pyrolysis products. Proc Jpn Acad 52: 58–61.

    Google Scholar 

  • Sugimura T, Sato S, Wakabayashi K (1988) Mutagens/carcinogens in pyrolysates of amino acids and proteins and in cooked foods: heterocyclic aromatic amines. In: Woo Y-T, Lai DY, Arcos JC, Argus MF, eds. Chemical Induction of Cancer, Vol. HIC, pp. 681–711. San Diego: Academic Press.

    Google Scholar 

  • Sugimura T, Wakabayashi K, Nagao M, Ohgaki H (1989) Heterocyclic amines in cooked food. In: Taylor SL, Scanlan RA, eds. Food Toxicology: A Perspective on the Relative Risk, pp. 31–55. New York: Marcel Dekker.

    Google Scholar 

  • Tasich M, Piper DW (1983) Effect of human colonie microsomes and cell-free extracts of Bacteroides fragilis on the mutagenicity of 2-aminoanthracene. Gastroenterology 85: 30–34.

    PubMed  CAS  Google Scholar 

  • Taylor SL (1986) Histamine food poisoning: toxicology and clinical aspects. CRC Crit Rev Toxicol 17: 91–128.

    Article  CAS  Google Scholar 

  • Taylor SL (1988) Marine toxins of microbial origin. Food Technol 42: 94–98.

    CAS  Google Scholar 

  • Thies E, Siegers C-P (1989) Metabolic activation and tumorigenesis. In: Koster AS, Richter E, Lauterbach F, Hartmann F, eds. Intestinal Metabolism of Xenobiotics, pp. 199–214. Stuttgart: Gustav Fisher Verlag.

    Google Scholar 

  • Timmis KN, Montenegro MA, Bulling E, Chakraborry T, Sanyal SC (1984) Genetics of toxin synthesis in gram negative enteric bacteria. In: Alouf JE, Freer JH, Fehrenbach FJ, Jeljaszewicz, ed. Bacterial Protein Toxins, pp. 13–27. London: Academic.

    Google Scholar 

  • Trefouel J, Trefouel J, Nitti F, Bovet D (1935) Activite du p-aminophenylsulfamide sur les infections streptococciques. Experimentales de la souris et due lapin. C R Seanc Soc Biol 120: 756–762.

    CAS  Google Scholar 

  • Trucksis M, Galen JE, Michalski J, Fasano A, Kaper JB. (1993) Accessory cholera enterotoxin (Ace), the third toxin of a Vibrio cholerae virulence cassette. Proc Natl Acad Sci USA 90: 5267–5271.

    Article  PubMed  CAS  Google Scholar 

  • Vadivelu J, Puthucheary SD, Navaratnam P (1991) Exotoxin profiles of clinical isolates of Aeromonas hydrophila. J Med Microbiol 34: 363–367.

    Article  PubMed  CAS  Google Scholar 

  • Vanos V, Hofstaetter S, Cox L (1987) The microbiology of instant tea. Food Microbiol 2: 187–197.

    Article  Google Scholar 

  • Vernet A, Seiss MH (1986) Comparison of the effects of various flavonoids on ethoxycou-marin deethylase activity of rat intestinal and hepatic microsomes. Food Chem Toxicol 24: 857–861.

    Article  PubMed  CAS  Google Scholar 

  • Vizethum W, Goerz G (1979) Induction of the hepatic microsomal and nuclear cytochrome P-450 system by hexachlorobenzene, pentachlorophenol, and trichlorophenol. Chem Biol Interact 28: 291–299.

    Article  PubMed  CAS  Google Scholar 

  • Walker R (1970) The metabolism of azo compounds: a review of the literature. Food Cosmet Toxicol 8: 659–676.

    Article  PubMed  CAS  Google Scholar 

  • Wallace WC, Letho ET, Brouwer EA (1970) The metabolism of cyclamate in rats. J Pharmacol Exp Ther 175: 325–330.

    PubMed  CAS  Google Scholar 

  • Wargovich MJ (1987) Diallyl sulfide, a flavor component of garlic (Allium sativum), inhibits dimethylhydrazine-induced colon cancer. Carcinogenesis 8: 487–489.

    Article  PubMed  CAS  Google Scholar 

  • Wasserman AE, Wolff IA (1981) Nitrates and nitrosamines in our environment. In: Ory RL, ed. Antinutrients and Natural Toxicants in Foods, pp. 35–52. Westport, Conn: F & N Press.

    Google Scholar 

  • Wattenberg LW (1975) Effect of dietary constitutents on the metabolism of chemical carcinogenesis. Cancer Res 35: 3326–3331.

    PubMed  CAS  Google Scholar 

  • Wattenberg LW (1978) Inhibition of chemical carcinogenesis. J Natl Cancer Inst 60: 11–18.

    PubMed  CAS  Google Scholar 

  • Wattenberg LW (1983) Inhibition of neoplasia by minor dietary constituents. Cancer Res S43: 2448–2453.

    Google Scholar 

  • Wei CI, Kitamura K, Shibamoto T (1981) Mutagenicity of Maillard browning products obtained from a starch-glycine model system. Food Chem Toxicol 19: 749–751.

    Article  CAS  Google Scholar 

  • White A, Handler P, Smith EL (1964) Principles of Biochemistry, 3rd ed. New York: McGraw-Hill.

    Google Scholar 

  • Wiestler O, von Deimling A, Kobori O, Kleihues P (1983) Location of N-methyl-N′-nitro-N-nitrosoguanidine-induced gastrointestinal tumors correlates with thiol distribution. Carcinogenesis 4: 879–883.

    Article  PubMed  CAS  Google Scholar 

  • Williams GM, McQueen CA, Tong C (1990a) Toxicity studies of butylated hydroxyanisol and butylated hydroxytoluene. 1. Genetic and cellular effect. Food Chem Toxicol 28: 793–798.

    Article  PubMed  CAS  Google Scholar 

  • Williams GM, Wang CX, Iatropoulos MG (1990b) Toxicity studies of butylated hydroxyanisole and butylated hydroxytoluene. 2. Chronic feeding studies. Food Chem Toxicol 28: 799–806.

    Article  PubMed  CAS  Google Scholar 

  • Wolfhagen MJ, Torensma R, Fluit AC, Verhoef J (1994) Toxins A and B of Clostridium difficile. FEMS Microbiol Rev 13: 59–64.

    Article  PubMed  CAS  Google Scholar 

  • Wollenberg P, Ullrich V (1980) The drug monooxygenase system in the small intestine. In: Gram TE, ed. Extrahepatic Metabolism of Drugs and Other Foreign Compounds, pp. 267–276. New York: S.P. Medical and Scientific Books.

    Google Scholar 

  • Wostmann BS (1984) Other organs. In: Coates ME, Gusstafsson BE, eds. The Germ-Free Animal in Biomedical Research, pp. 215–231. London: Laboratory Animals.

    Google Scholar 

  • Yamamoto T, Tsuji K, Kosuge T, et al. (1978). Isolation and structure determination of mutagenic substances in L-glutamic acid pyrolysates. Proc Jpn Acad 54B: 248–250.

    Google Scholar 

  • Yamamoto T, Tamura T, Yokota T, Takano T (1982) Overlapping genes in the heat-labile enterotoxin operon originating from Escherichia coli human strain. Mol Gen Genet 188: 356–359.

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto T, Tamura T, Yokota T (1984) Primary structure of heat-labile enterotoxin produced by Escherichia coli pathogenic for humans. J Biol Chem 259: 5037–5044.

    PubMed  CAS  Google Scholar 

  • Yamamoto M, Yamada T, Yoshihira K, Tanimura A, Tomita I (1988) Effects of food components and additives on the formation of nitrosamides. Food Addit Contam 5: 289–298.

    Article  PubMed  CAS  Google Scholar 

  • Yang CS, Brady JF, Hong J-Y (1992) Dietary effects on cytochromes P450, xenobiotic metabolism, and toxicity. FASEB J 6: 737–744.

    PubMed  CAS  Google Scholar 

  • Yasumoto T, Murata M, Oshima Y, Matsumoto GK, Clardy J (1984) Diarrhetic shellfish poisoning. In: Ragelis EP, ed. Seafood Poisoning. Washington, DC: American Chemical Society.

    Google Scholar 

  • Yoh M, Yamamoto K, Honda T, Takeda Y, Miwatani T (1983) Effect of lincomycin and tetracycline on production and properties of enterotoxigenic Escherichia coli. Infect Immun 42: 778–782.

    PubMed  CAS  Google Scholar 

  • Yokoda M, Narita K, Kosuge T, et al. (1981) A potent mutagen isolated from a pyrolysate of L-ornithine. Chem Pharm Bull 29: 1473–1475.

    Article  Google Scholar 

  • Yoshida D, Matsumoto T, Yoshimura R, Mizusaki T. (1978) Mutagenicity of amino-α-carbolines in pyrolysis products of soybean globulin. Biochem Biophys Res Commun 83: 915–920.

    Article  PubMed  CAS  Google Scholar 

  • Yu C, Swaminathan B, Butler L (1986) Isolation and identification of rutin as the major mutagen in red wine. Mutat Res 170: 103–113.

    Article  PubMed  CAS  Google Scholar 

  • Zachariah PK, Juchau MR (1974) The role of gut flora in the reduction of aromatic nitrogroups. Drug Metab Dispos 2: 74–78.

    PubMed  CAS  Google Scholar 

  • Zeiger E, Dunkel VC (1991) Mutagenicity of chemicals added to foods. In: Hayatsu H, ed. Mutagens in Food: Detection and Prevention, pp. 51–55. Boca Raton, Fla: CRC Press.

    Google Scholar 

  • Zhang Y, Talalay P, Cho C-G, Posner GH (1992) A major inducer of anticarcinogenic protective enzymes from broccoli and elucidation of structure. Proc Natl Acad Sci USA 89: 2399–2403.

    Article  PubMed  CAS  Google Scholar 

  • Zlotlow MJ, Settipane GA (1977) Allergic potential of food additives: a report of a case of tartrazine sensitivity without aspirin intolerance. Am J Clin Nutr 30: 1023–1025.

    PubMed  CAS  Google Scholar 

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Chung, KT. (1997). Gastrointestinal Toxicology of Monogastrics. In: Mackie, R.I., White, B.A. (eds) Gastrointestinal Microbiology. Chapman & Hall Microbiology Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4111-0_14

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