Abstract
An hypothesis is presented to explain the changing pattern of colorectal cancer seen within the United States and other western countries in the last 30 years, the simultaneous increase of right-sided colonic cancer and disappearance of rectal cancer. Review of experimental and epidemiologic data suggests that this change may be due to a new systemic deficiency of the trace element selenium. This deficiency has arisen not just from decreased consumption of selenium in the last 30 years, but also from increased consumption of zinc and fluoride, which may antagonize the effect of selenium.
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References
McMichael AJ, Potter JD. Reproduction, endogenous and exogenous sex hormones and colon cancer: a review and hypothesis. J Natl Cancer Inst 1980;65:1201–6.
McMichael AJ, Potter JD, Hetzel BS. Time trends in colo-rectal cancer mortality in relation to food and alcohol consumption: United States, United Kingdom, Australia and New Zealand. Int J Epidemiol 1979;8:295–303.
Rhodes JB, Holmes FF, Clark GM. Changing distribution of primary cancers in the large bowel. JAMA 1977;238:1641–3.
Mamazza J, Gordon PH. The changing distribution of large intestinal cancer. Dis Colon Rectum 1982;25:558–62.
Nelson RL. Experimental colon cancer: what animal models have demonstrated about the origin of human colon cancer. Curr Surg 1983;40:419–23.
Gilbertsen VA. Proctosigmoidoscopy and polypectomy in reducing the incidence of rectal cancer. Cancer 1974;34:939–9.
Lamont JT, O'Gorman TA. Experimental colon cancer. Gastroenterology 1978;75:1157–69.
Soullier BK, Wilson PS, Nigro ND. Effect of selenium on azoxymethane-induced intestinal cancer in rats fed a high fat diet. Cancer Lett 1981;12:343–8.
Young VR. Selenium: a case for its essentiality in man. N Engl J Med 1981;304:1228–30.
Jansson B, Jacobs, MM, Griffin AC. Gastrointestinal cancer; epidemiology and experimental studies. In: Schrauser GN. Inorganic and nutritional aspects of cancer. Adv Exp Biol Med 1978;91:306.
Schrauser GN. Trace elements, nutrition and cancer: perspectives and prevention. In: Inorganic and nutritional aspects of cancer. Adv Exp Biol Med 1978;91:323.
Beitz DC, Hanson RG. Animal products in nutrition. New York: Academic Press, 1982:288–90.
Cook-Mozaffari P, Doll R. Fluoridation of water supplies and cancer mortality. I, II and III. J Epidemiol Community Health 1981;35:227–44.
Hoover RN, McKay FW, Fraumeni JF. Fluoridated drinking water and the occurrence of cancer. J Natl Cancer Inst 1976;57:757–68.
Tank G, Storvick CA. Effect of naturally occurring selenium and vanadium on dental caries. J Dent Res 1960;39:473–5.
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Richard, N.L. Is the changing pattern of colorectal cancer caused by selenium deficiency?. Dis Colon Rectum 27, 459–461 (1984). https://doi.org/10.1007/BF02555539
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DOI: https://doi.org/10.1007/BF02555539