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Proteoglycans and Hyaluronan in Morphogenesis and Differentiation

  • Chapter
Cell Biology of Extracellular Matrix

Abstract

The objective of this chapter is to discuss the roles of hyaluronan (HA) and proteoglycans (PGs) in developmental processes and tissue remodeling. In the first section I have summarized recent progress on the molecular basis of HA and PG interactions with the surface of cells, since this is the most likely means whereby HA and PGs would influence cell behavior during development. This is followed by a review of cellular studies, mainly performed in vitro, that implicate HA and PGs in specific aspects of cell behavior that would be relevant to development in vivo. Finally, I have chosen three developmental systems to illustrate ways in which HA or PGs are involved in actual morphogenetic and differentiative processes.

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  1. Department of Anatomy and Cellular Biology, Tufts University Health Science Schools, Boston, Massachusetts, 02111, USA

    Bryan P. Toole

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  1. Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Elizabeth D. Hay

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Toole, B.P. (1991). Proteoglycans and Hyaluronan in Morphogenesis and Differentiation. In: Hay, E.D. (eds) Cell Biology of Extracellular Matrix. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3770-0_10

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