Abstract
Most studies on ageing describe an age-related muscle fibre atrophy and an increase in the percentage of type I (oxidative) and IIa (oxidative glycolytic) fibres and a decrease in the percentage of IIb (glycolytic) fibres (Kovanen, 1989). Compensatory hypertrophy is characterised by enlargement of existing fibres and an increased percentage of type I fibres (Riedy et al., 1985). Since muscle fibre type and size are correlated with the capillary supply to a fibre (Egginton and Ross, 1989), changes in muscle capillary supply might accompany changes in fibre type composition and fibre cross-sectional areas. Absence of capillary proliferation with hypertrophy would result in increased diffusion distances from the capillary to the interior of fibres, which might impede the delivery of oxygen to the interior of fibres. However, little is known about capillarisation in ageing rat muscles not to mention capillarisation in hypertrophied ageing muscle. Therefore, in the present study we investigated the capillarisation in muscles at various ages and, in particular, we wanted to elucidate whether compensatory hypertrophy in ageing muscle was accompanied by capillary proliferation. This was done by the extended method of Capillary Domains as developed by Hoofd et al. (1985; Egginton and Ross, 1989).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Batra, S., Rakusan, K., and Kuo, C., 1989, Spatial distribution of coronary capillaries: A-V segment staggering. in: Oxygen Transport to Tissue-XI. Eds. K. Rakusan, G.P. Biro, T.K. Goldstick, Z. Turek, Plenum Press, New York and London, pp 241–247.
Binkhorst, R.A., 1969, The effect of training on some isometric contraction characteristics of a fast muscle. Pfügers Arch. 309:193–202.
Egginton, S., and Ross, H.F., 1989, Influence of muscle phenotype on local capillary supply. in: Oxygen Transport to Tissue-XI. Eds. K. Rakusan, G.P. Biro, T.K. Goldstick, Z. Turek, Plenum Press, New York and London, pp 281–291.
Egginton, S., Turek, Z., and Hoofd, L.J.C., 1988, Differing patterns of capillary distribution in fish and mammalian skeletal muscle. Resp. Physiol. 74:383–396.
Gollnick, P.D., Timson, B.F., Moore, R.L., and Riedy, M., 1981, Muscular enlargement and number of fibers in skeletal muscles of rats. J. Appl. Physiol. 50:936–943.
Hoofd, L., Turek, Z., Kubat, K., Ringnalda, B.E.M., and Kazda, S., 1985, Variability of intercapillary distance estimated on histological sections of rat heart. in: Oxygen Transport to Tissue-VII. Eds. F. Kreuzer, S.M. Cain, Z. Turek, T.K. Goldstick, Plenum Press, New York, pp. 239–247.
Kovanen, V., 1989, Effects of ageing and physical training on rat skeletal muscle. An experimental study on the properties of collagen, laminin, and fibre types in muscles serving different functions. Acta Physiol. Scand. 135 (S577):7–56.
Riedy, M., Moore R.L., and Gollnick, P.D., 1985, Adaptive response of hypertrophied muscle to endurance training. J. Appl. Physiol. 59:127–131.
Wallenstein, S., Zucker, C.L., and Fleiss, J.L., 1980, Some statistical methods useful in circulation research. Circ. Res. 47:1–9.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media New York
About this chapter
Cite this chapter
Degens, H., Turek, Z., Hoofd, L.J.C., Binkhorst, R.A. (1994). Capillary Proliferation Related to Fibre Types in Hypertrophied Aging Rat M. Plantaris. In: Vaupel, P., Zander, R., Bruley, D.F. (eds) Oxygen Transport to Tissue XV. Advances in Experimental Medicine and Biology, vol 345. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2468-7_88
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2468-7_88
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6051-3
Online ISBN: 978-1-4615-2468-7
eBook Packages: Springer Book Archive