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Lactic Acid Bacteria as Promoters of Human Health

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Functional Foods

Abstract

Great interest in the healthful effects of lactic acid bacteria exists in the research, commercial, and consuming communities. The designation “lactic acid bacteria” applies to a functional grouping of non-pathogenic, gram positive bacteria that have lactic acid as a primary metabolic end-product and are traditionally used in food fermentations. These bacteria include species of Lactococcus, Lactobacillus, Streptococcus, Leuconostoc, and Pediococcus. Bifidobacterium and Enterococcus species are also included in this group when addressing issues related to bacterial inoculants for health promotion. For some health-promoting applications, lactic acid bacteria of intestinal origin are specifically targeted. These include Lactobacillus species of intestinal origin, all species of Bifidobacterium, and Enterococcus faecalis. Research is sometimes conducted on the bacterial strains themselves, or sometimes on the food products that harbor these bacteria. Normally, the food products tested are milk products, including fermented milks such as yogurt and buttermilk, and unfermented milks with culture added. Recent reviews have been published covering this field in general (AIm 1991; Goldin 1989, 1990; Gorbach 1989, 1990; Bourlioux and Pochart 1988; de Simone et al. 1989; Fernandes, Shahani, and Amer 1987; Friend and Shahani 1984; Fuller 1991; Gurr 1984; Kim 1988; Kroger, Kurmann, and Rasic 1989; Lemonnier 1984; Rasic 1983; Renner 1991; Sellars 1989, 1991) or specifically focusing on lactose intolerance (Savaiano and Kotz 1988; Savaiano and Levitt 1987), gastrointestinal microbiology (Bianchi-Salvadori 1986; Brown 1977; Gorbach 1971, 1986; Savage 1977, 1983a, b; Tannock 1983, 1984, 1990), antimicrobial activities (Fernandes and Shahani 1989), anticarcinogenic properties (Fernandes and Shahani 1990), vaginal health (Redondo-Lopez, Cook, and Sobel 1990), Bifidobacteria (Bezkorovainy and Miller-Catchpole 1989; Hughes and Hoover 1991; Kurmann and Rasic 1991; Laroia and Martin 1990; Misra and Kuila 1991; Mitsuoka 1989, 1990; Modler, McKellar, and Yaguchi 1990; Poupard, Husain, and Norris 1973; Rasic and Kurmann 1983), L. acidophilus (Fonden 1989; Truslow 1986), and strain selection for dietary adjuncts (Gorbach and Goldin 1989; Klaenhammer 1982).

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References

  • Ahrens, E.H., Jr. 1985. The diet-heart question in 1985: Has it really been settled? Lancet ii: 1085–1087.

    Article  Google Scholar 

  • Alm, L. 1991. The therapeutic effects of various cultures-an overview. In Therapeutic Properties of Fermented Milks, R.K. Robinson, ed., pp. 45–64. New York: Elsevier Applied Science.

    Google Scholar 

  • Alm, L., Humble, D.; Ryd-Kjellen, E.; and Setterberg, G. 1983. The effect of acidophilus milk in the treatment of constipation in hospitalized geriatric patients. In Nutrition and the Intestinal Flora, Bo Hallgren, ed., pp. 131–138. Stockholm, Sweden: Symposia of the Swedish Nutrition Foundation XV, Almqvist & Wiksell International.

    Google Scholar 

  • Ayebo, A.D.; Angelo, I.A.; and Shahani, K.M. 1980. Effect of ingesting Lactobacillus acidophilus (sic) milk upon fecal flora and enzyme activity in humans. Milchwissenschaft 35: 730–73.

    Google Scholar 

  • Bazzarre, T.L.; Liu Wu, S.; and Yuhas, J.A. 1983. Total and HDL-cholesterol concentrations following yogurt and calcium supplementation. Nutr. Rep. Int. 28: 1225–1232.

    CAS  Google Scholar 

  • Beck, C., and Necheles, H. 1961. Beneficial effects of administration of Lactobacillus acidophilus (sic) in diarrheal and other intestinal disorders. Amer. J. Gastroenterol. 35: 522–530.

    CAS  Google Scholar 

  • Bellomo, G.; Mangiagle, A.; Nicastro, L.; and Frigerio, G. 1980. A controlled double-blind study of SF68 strain as a new biological preparation for the treatment of diarrhea in pediatrics. Curr. Therap. Res. 28: 927–936.

    Google Scholar 

  • Bezkorovainy, A., and Miller-Catchpole, R. 1989. Biochemistry and Physiology of Bifidobacteria. Boca Raton, Florida: CRC Press.

    Google Scholar 

  • Bianchi-Salvadori, B. 1986. Intestinal microflora: The role of yogurt in the equilibrium of the gut ecosystem. Int. J. Immunotherapy (Suppl.) 11: 9–18.

    Google Scholar 

  • Bogdanov, E.G.; Dalev, P.G.; Gurevich, A.I.; Kolosov, M.N.; Mal’kova, V.P.; Plemyannikova, L.A.; and Sorokina, I.B. 1975. Antitumor glycopeptides from Lactobacillus bulgaricus cell wall. FEBS Lett. 57: 259–261.

    Article  CAS  Google Scholar 

  • Bourlioux, R., and Pochart, P. 1988. Nutritional and health properties of yogurt. Wld. Rev. Nutr. Diet. 56: 217–258.

    CAS  Google Scholar 

  • Brown, J.P. 1977. Role of gut bacterial flora in nutrition and health: A review of recent advances in bacteriological techniques, metabolism, and factors affecting flora composition. CRC Crit. Rev. Food Sci. Nutr. 8: 229–336.

    Article  CAS  Google Scholar 

  • Clements, M.L.; Levine, M.M.; Ristaino, P.A.; Daya, V.E.; and Hughes, T.P. 1983. Exogenous lactobacilli fed to man-their fate and ability to prevent diarrheal disease. Prog. Fd. Nutr. Sci. 7: 29–37.

    CAS  Google Scholar 

  • Clements, M.L.; Levine, M.M.; and Black, R.E. 1981. Lactobacillus prophylaxis for diarrhea due to enterotoxigenic Escherichia coli. Antimicrob. Agents Chemother. 20: 104–108.

    Article  CAS  Google Scholar 

  • Colombel, J.F.; Cortot, A.; Neut, C.; and Romond, C. 1987. Yogurt with Bifidobacterium longum reduces erythromycin-induced gastrointestinal effects. Lancet ii: 43.

    Article  Google Scholar 

  • Danielson, A.D.; Peo, E.R., Jr.; Shahani, K.M.; Lewis, A.J.; Whalen, P.J.; and Amer, M.A. 1989. Anticholesteremic property of Lactobacillus acidophilus yogurt fed to mature boars. J. Anim. Sci. 67: 966–974.

    CAS  Google Scholar 

  • de Simone, C.; Bianchi Salvadori, B.; Jirillo, E.; Baldinessi, L.; Bitonti, F.; and Vesely, R. 1989. Health properties of yogurt. In Yogurt: Nutritional and Health Properties, R.C. Chandan, ed., pp. 201–213. McLean, VA: National Yogurt Association.

    Google Scholar 

  • Drasar, B.S., and Hill, J.F. 1972. Intestinal bacteria and cancer. Amer. J. Clin. Nutr. 25: 1399–1404.

    CAS  Google Scholar 

  • Driessen, F.M., and de Boer, R. 1989. Fermented milks with selected intestinal bacteria: A healthy trend in new products. Neth. Milk Dairy J. 43: 367–382.

    Google Scholar 

  • Fernandes, C.F., and Shahani, K.M. 1989. Modulation of antibiosis by lactobacilli and yogurt and its healthful and beneficial significance. In Yogurt: Nutritional and Health Properties, R.C. Chandan, ed., pp. 145–160. McLean, VA: National Yogurt Association.

    Google Scholar 

  • Fernandes, C.F., and Shahani, K.M. 1990. Anticarcinogenic and immunological properties of dietary lactobacilli. J. Food Protect. 53: 704–710.

    Google Scholar 

  • Fernandes, C.F.; Shahani, K.M.; and Amer, M.A. 1987. Therapeutic role of dietary lactobacilli and lactobacillic fermented dairy products. FEMS Microbiol. Rev. 46: 343–356.

    Article  Google Scholar 

  • Fonden, R. 1989. Lactobacillus acidophilus. In Les Laits Fermentes. Actualite de la Rechercher pp. 35–40. Montrouge, France: John Libbey Eurotext.

    Google Scholar 

  • Friend, B.A., and Shahani, K.M. 1984. Nutritional and therapeutic aspects of lactobacilli. J. App. Nutr. 36: 125–153.

    CAS  Google Scholar 

  • Fuller, R. 1991. Probiotics in human medicine. Gut 32: 439–442.

    Article  CAS  Google Scholar 

  • Gilliland, S.E.; Nelson, C.R.; and Maxwell, C. 1985. Assimilation of cholesterol by Lactobacillus acidophilus. Appl. Environ. Microbiol. 49: 377–381.

    CAS  Google Scholar 

  • Gilliland, S.E., and Walker, D.K. 1990. Factors to consider when selecting a culture of Lactobacillus acidophilus as a dietary adjunct to produce a hypocholesterolemic effect in humans. J. Dairy Sci. 73: 905–911.

    Article  CAS  Google Scholar 

  • Goldin, B.R. 1989. Lactic acid bacteria: Implications for health. In Les Laits Fermentes. Actualite de la Recherche, pp. 95–104. Montrouge, France: John Libbey Eurotext.

    Google Scholar 

  • Goldin, B.R. 1990. Intestinal microflora: Metabolism of drugs and carcinogens. Ann. Medicine 22: 43–48.

    Article  CAS  Google Scholar 

  • Goldin, B.R.; Swenson, L.; Dwyer, J.; Sexton, M.; and Gorbach, S.L. 1980. Effect of diet and Lactobacillus acidophilus supplements on human fecal bacterial enzymes. J. Natl. Cane. Instit. 64: 255–261.

    CAS  Google Scholar 

  • Goldin, B.R.; Gorbach, S.L.; Saxelin, M.; Barakat, S.; Gualtiere, L.; and Salminen, S. 1992. Survival of Lactobacillus species (Strain GG) in human gastrointestinal tract. Digestive Diseases and Sci. 37: 121–128.

    Article  CAS  Google Scholar 

  • Goldin, B., and Gorbach, S.L. 1977. Alterations in fecal microflora enzymes related to diet, age, Lactobacillus (sic) supplements and dimethylhydrazine. Cancer 40: 2421–2426.

    Article  CAS  Google Scholar 

  • Goldin, B. 1980. Effect of Lactobacillus acidophilus dietary supplements on 1, 2-dimethylhydrazine in dihydrochloride-induced intestinal cancer in rats. J. Natl. Cane. Instit. 64: 263–265.

    CAS  Google Scholar 

  • Goldin, B. 1984a. The Effect of oral administration on Lactobacillus and antibiotics on intestinal bacterial activity and chemical induction of large bowel tumors. Dev. Indus. Microbiol. 25: 139–150.

    CAS  Google Scholar 

  • Goldin, B. 1984b. The effect of milk and Lactobacillus (sic) feeding on human intestinal bacterial enzyme activity. Amer. J. Clin. Nutr. 39: 756–761.

    CAS  Google Scholar 

  • Gorbach, S.L. 1971. Progress in gastroenterology. Intestinal microflora. Gastroenterol. 60: 1110–1129.

    CAS  Google Scholar 

  • Gorbach, S.L. 1986. Function of the normal human microflora. Scand. J. Infect. Dis. (Suppl) 49: 17–30.

    CAS  Google Scholar 

  • Gorbach, S.L. 1989. Metabolism of carcinogens and drugs by the intestinal flora: Effects of Lactobacillus. In Les Laits Fermentes. Actualite de la Recherche, pp. 85–94. Montrouge, France: John Libbey Eurotext.

    Google Scholar 

  • Gorbach, S.L. 1990. Lactic acid bacteria and human health. Ann. Medicine 22: 37–41.

    Article  CAS  Google Scholar 

  • Gorbach, S.L.; Chang, T.-W.; and Goldin, B. 1987. Successful treatment of relapsing Clostridium difficile (sic) colitis with Lactobacillus (sic) GG. Lancet ii: 1519.

    Article  Google Scholar 

  • Gorbach, S.L., and Goldin, B.R. 1989. Lactobacillus (sic) strains and methods of selection. US Patent Number 4, 839, 281.

    Google Scholar 

  • Graf, W. 1983. Studies on the therapeutic properties of acidophilus milk. In Nutrition and the Intestinal Flora, Bo Hallgren, ed., pp. 119–121. Stockholm, Sweden: Symposia of the Swedish Nutrition Foundation XV, Almqvist & Wiksell International.

    Google Scholar 

  • Gurr, M.I. 1984. Fermented milks, intestinal microflora and nutrition. International Dairy Federation Bulletin 179: 54–59.

    Google Scholar 

  • Halpern, G.M.; Vruwing, K.G.; van de Water, J.; Keen, C.L.; and Gershwin, M.E. 1991. Influence of long-term yoghurt consumption in young adults. Int. J. Immunotherapy VII: 205–210.

    Google Scholar 

  • Hepner, G.; Fried, R.; St. Jeor, S.; Fusetti, L.; and Morin, R. 1979. Hypocholesterolemic effect of yogurt and milk. Amer. J. Clin. Nutr. 32: 19–24.

    CAS  Google Scholar 

  • Hilton, E.; Isenberg, H.D.; Alperstein, P.; France, K.; and Borenstein, M.T. 1992. Ingestion of yogurt containing Lactobacillus acidophilus as prophylaxis for candidal vaginitis. Annals of Internal Medicine 116: 353–357.

    CAS  Google Scholar 

  • Hosono, A.; Kashina, T.; and Kada, T. 1986. Antimutagenic properties of lactic acid-cultured milk on chemical and fecal mutagens. J. Dairy Sci. 69: 2237–2242.

    Article  CAS  Google Scholar 

  • Hotta, M.; Sato, Y.; Iwata, S.; Yamashita, N.; Sunakawa, K.; Oikawa, T.; Tanaka, R.; Watanabe, K.; Takayama, H.; Yajima, M.; Sekiguchi, S.; Arai, S.; Sakurai, T.; and Mutai, M. 1987. Clinical effects of Bifidobacterium preparations on pediatric intractable diarrhea. Keio. J. Med. 36: 298–314.

    Article  CAS  Google Scholar 

  • Hughes, D.B., and Hoover, D.G. 1991. Bifidobacteria: Their potential for use in American dairy products. Food Technol. 45: 74–83.

    Google Scholar 

  • Isolauri, E.; Juntunen, M.; Rautanen, T.; Sillanaukee, P.; and Koivula, T. 1991. A human Lactobacillus strain (Lactobacillus casei sp. strain GG) promotes recovery from acute diarrhea in children. Pediatrics 88: 90–97.

    CAS  Google Scholar 

  • Jaspers, D.A.; Massey, L.K.; and Luedecke, L.O. 1984. Effect of consuming yogurts prepared with 3 culture strains on human serum lipoproteins. J. Food Sci. 49: 1178–1181.

    Article  CAS  Google Scholar 

  • Kato, I.; Kobayashi, S.; Yokokura, T.; and Mutai, M. 1981. Antitumor activity of Lactobacillus casei in mice. Gann 72: 517–523.

    CAS  Google Scholar 

  • Kim, H.S. 1988. Characterization of lactobacilli and bifidobacteria as applied to dietary adjuncts. Cult. Dairy Prod. J. August: 6–9.

    Google Scholar 

  • Kim, H.S., and Gilliland, S.E. 1983. Lactobacillus acidophilus as a dietary adjunct for milk to aid lactose digestion in humans. J. Dairy Sci. 66: 959–966.

    Article  CAS  Google Scholar 

  • Kitazowa, H.; Nomura, M.; Itoh, T.; and Yamaguchi, T. 1991. Functional alteration of macrophages by a slime-forming Lactobacillus lactis ssp. cremoris. J. Dairy Sci. 74: 2082–2088.

    Article  Google Scholar 

  • Klaenhammer, T.R. 1982. Microbiological considerations in selection and preparation of Lactobacillus strains for use as dietary adjuncts. J. Dairy. Sci. 65: 1339–1349.

    Article  Google Scholar 

  • Klaenhammer, T.R. 1988. Bacteriocins of lactic acid bacteria. Biochimie 70: 337–349.

    Article  CAS  Google Scholar 

  • Kohwi, T.; Imai, K.; Tamura, A.; and Hashimoto, Y. 1978. Antitumor effect of Bifidobacterium infantis in mice. Gann 69: 613–618.

    CAS  Google Scholar 

  • Kolars, J.C.; Levitt, M.D.; Aouji, M.; and Savaiano, D.A. 1984. Yogurt-An auto-digesting source of lactose. N. Engl. J. Med. 310: 1–3.

    Article  CAS  Google Scholar 

  • Koo, M., and Rao, A.V. 1991. Long-term effect of Bifidobacteria and neosugar on precursor lesions of colonic cancer in CF, mice. Nutrition and Cancer 16: 249–257.

    Article  CAS  Google Scholar 

  • Kroger, M.; Kurmann, J.A.; and Rasic, J.L. 1989. Fermented milks-Past, present, and future. Food Technol. 43: 92–98.

    Google Scholar 

  • Kurmann, J.A., and Rasic, J. Lj. 1991. The health potential of products containing Bifidobacteria. In Therapeutic Properties of Fermented Milks, R.K. Robinson, ed., pp. 117–157. New York: Elsevier Applied Science.

    Google Scholar 

  • Laroia, S., and Martin, J.H. 1990. Bifidobacteria as possible dietary adjuncts in cultured dairy products-A review. Cult. Dairy Prod. J. 25: 18–22.

    Google Scholar 

  • Lemonnier, D. 1984. Fermented milks and health. International Dairy Federation Bulletin 179: 60–68.

    CAS  Google Scholar 

  • Lin, M.-Y.; Savaiano, D.; Harlander, S. 1991. Influence of nonfermented dairy products containing bacterial starter cultures on lactose maldigestion in humans. J. Dairy Sci. 74: 87–95.

    Article  CAS  Google Scholar 

  • Lin, S.Y.; Ayres, J.W.; Winkler, W., Jr.; and Sandine, W.E. 1989. Lactobacillus effects on cholesterol: In vitro and in vivo results. J. Dairy Sci. 72: 2885–2899.

    Article  CAS  Google Scholar 

  • Marteau, P.; Pochart, P.; Flourie, B.; Pellier, P.; Santos, L.; Desjeux, J.F.; and Rambaud, J.C. 1990. Effect of chronic ingestion of a fermented dairy product containing Lactobacillus acidophilus and Bifidobacterium bifidum on metabolic activities of the colonic flora in humans. Amer. J. Clin. Nutr. 52: 685–688.

    CAS  Google Scholar 

  • Martini, M.C.; Kukielka, D.; and Savaiano, D.A. 1991. Lactose digestion from yogurt: Influence of a meal and additional lactose. Amer. J. Clinic. Nutr. 53: 1253–1258.

    CAS  Google Scholar 

  • Martini, M.C.; Lerebours, E.C.; Lin, W.-J.; Harlander, S.K.; Berrada, N.M.; Antoine, J.M.; and Savaiano, D.A. 1991. Strains and species of lactic acid bacteria in fermented milks (yogurts): Effect on in vivo lactose digestion. Amer. J. Clin. Nutr. 54: 1041–1046.

    CAS  Google Scholar 

  • McConnell, M.A., and Tannock, G.W. 1991. Lactobacilli and azoreductase activity in the murine cecum. Appl. Environ. Microbiol. 57: 3664–3665.

    CAS  Google Scholar 

  • McDonough, F.E.; Wong, N.P.; Hitchins, A.; and Bodwell, C.E. 1987. Alleviation of lactose malabsorption from sweet acidophilus milk. Amer. J. Clin. Nutr. 42: 345–346.

    Google Scholar 

  • McGroatry, J.A.; Hawthorn, A.-A.; and Reid, G. 1988. Anti-tumor activity of Lactobacilli in vitro. Microbios Lett. 39: 105–112.

    Google Scholar 

  • Misra, A.K., and Kuila, R.K. 1991. The selection of Bifidobacteria for the manufacture of fermented milks. Austr. J. Dairy Technol. May: 24–26.

    Google Scholar 

  • Mitsuoka, T. 1989. Bifidobacterium microecology. In Les Laits Fermentes. Actualite de la Recherche, pp. 41–48. Montrouge, France: John Libbey Eurotext.

    Google Scholar 

  • Mitsuoka, T. 1990. Bifidobacteria and their role in human health. J. Indust. Microbiol. 6: 263–268.

    Article  Google Scholar 

  • Modler, G.W.; McKellar, R.C.; and Yaguchi, M. 1990. Bifidobacteria and bifidogenic factors. Can. Inst. Food Sci. Technol. J. 23: 29–41.

    CAS  Google Scholar 

  • Newcomer, A.D.; Park, H.S.; O’Brien, P.C.; and McGill, D.B. 1983. Response of patients with irritable bowel syndrome and lactase deficiency using unfermented acidophilus milk. Amer. J. Clin. Nutr. 38: 257–263.

    CAS  Google Scholar 

  • Oksanen, P.J.; Salminen, S.; Saxelin, M.; Hamalainen, P.; Ihantola-Vormisto, A.; Muurasniemi-Isoviita, L.; Nikkari, S.; Oksanen, T.; Porsti, I.; Salminen, E.; Siitonen, S.; Stuckey, H.; Toppila, A. d Vapaatalo, H. 1990. Prevention of travellers’ diarrhoea by Lactobacillus GG. Ann. Medicine 22: 53–56.

    Article  CAS  Google Scholar 

  • Pearce, J.L., and Hamilton, J.R. 1974. Controlled trial of orally administered lactobacilli in acute infantile diarrhea. J. Pediat. 84: 261–262.

    Article  CAS  Google Scholar 

  • Perdigon, G.; Nader de Macias, M.E.; Alvarez, S.; Medici, M.; Oliver, G.; and Pesce de Ruiz Holgado, A. 1986a. Effect of a mixture of Lactobacillus casei and Lactobacillus acidophilus administered orally on the immune system in mice. J. Food. Protect. 49: 986–989.

    Google Scholar 

  • Perdigon, G.; Nader de Macias, M.E.; Alvarez, S.; Oliver, G.; and Pesce de Ruiz Holgado, A. A. 1986b. Effect of perorally administered lactobacilli on macrophage activation in mice. Infection and Immunity 53: 404–410.

    CAS  Google Scholar 

  • Perdigon, G.; Nader de Macias, M.E.; Alvarez, S.; Oliver, G.; and Pesce de Ruiz Holgado, A.A. 1987. Enhancement of immune response in mice fed with Streptococcus thermophilus and Lactobacillus acidophilus. J. Dairy Sci. 70: 919–926.

    Article  CAS  Google Scholar 

  • Perdigon, G.; Alvarez, S.; Nader de Macias, M.E.; and Medici, M. 1989. Effect of lactic acid bacteria orally administered and of yoghurt on the immune system. In Les Laits Fermentes. Actualite de la Recherche, pp. 77–84. Montrouge, France: John Libbey Eurotext.

    Google Scholar 

  • Perdigon, G.; Nader de Macias, M.E.; Alvarez, S.; Oliver, G.; and Pesce de Ruiz Holgado, A.A. 1990. Prevention of gastrointestinal infection using immunobiological methods with milk fermented with Lactobacillus casei and Lactobacillus acidophilus. J. Dairy Res. 57: 255–264.

    Article  CAS  Google Scholar 

  • Poupard, J. A.; Husain, I.; and Norris, R.F. 1973. Biology of the bifidobacteria. Bacteriol. Rev. 37: 136–165.

    CAS  Google Scholar 

  • Pozo-Olano, J.D.; Warram, J.G., Jr., Gomez, R.G.; and Cavazos, M.G. 1978. Effect of a Lactobacilli preparation on traveler’s diarrhea: A randomized, double blind clinical trial. Gastroenterology 74: 829–830.

    Google Scholar 

  • Rasic, J.Lj. 1983. The role of dairy foods containing bifido- and acidophilus bacteria in nutrition and health? N. Europ. Dairy J. 4: 2–10.

    Google Scholar 

  • Rasic, J.Lj., and Kurmann, J.A. 1983. Bifidobacteria and their role. Microbiological, Nutritional- Physiological, Medical and Technological Aspects and Bibliography. Basel, Switzerland: Birkhäuser Verlag.

    Google Scholar 

  • Rasic, J.Lj.; Vujicic, I.R.; Skrinjar, M.; and Vulic, M. 1992. Assimilation of cholesterol by some cultures of lactic acid bacteria and Bifidobacteria. Biotechnol. Bull. 14: 39–44.

    CAS  Google Scholar 

  • Redondo-Lopez, V.; Cook, R.L.; and Sobel, J.D. 1990. Emerging role of Lactobacilli in the control and maintenance of the vaginal bacterial microflora. Rev. Infect. Diseases 12: 856–872.

    Article  CAS  Google Scholar 

  • Renner, E. 1991. Cultured dairy products in human nutrition. International Dairy Federation Bulletin 255: 2–24.

    CAS  Google Scholar 

  • Rossouw, J.E.; Burger, E.-M.; van der Vyver, P.; and Ferreira, J.J. 1981. The effect of skim milk, yogurt, and full cream milk on human serum lipids. Amer. J. Clin. Nutr. 34: 351–356.

    CAS  Google Scholar 

  • Salminen, E.; Elomaa, I.; Minkkinen, J.; Vapaatalo, H.; and Salminen, S. 1988. Preservation of intestinal integrity during radiotherapy using live Lactobacillus acidophilus cultures. Clin. Radiol. 39: 435–437.

    Article  CAS  Google Scholar 

  • Savage, D.C. 1977. Microbial ecology of the gastrointestinal tract. Ann. Rev. Microbiol. 31: 107–133.

    Article  CAS  Google Scholar 

  • Savage, D.C. 1983a. Associations of indigenous microorganisms with gastrointestinal epithelial surfaces. In Human Intestinal Microflora in Health and Disease, D.J. Hentges, ed., pp. 55–78, New York: Academic Press, Inc.

    Google Scholar 

  • Savage, D.C. 1983b. Morphological diversity among members of the gastrointestinal microflora. International Rev. Cytol. 82: 305–334.

    Article  CAS  Google Scholar 

  • Savaiano, D.A.; Abou El Anovar, A; Smith, D.E.; and Levitt, M.D. 1984. Lactose malabsorption from yogurt, pasteurized yogurt, sweet acidophilus milk, and cultured milk in lactose-deficient individuals. Amer. J. Clin. Nutr. 40: 1219–1223.

    CAS  Google Scholar 

  • Savaiano, D.A., and Kotz, C. 1988. Recent advances in the management of lactose intolerance. Comtemporary Nutrition. 13: 10.

    Google Scholar 

  • Savaiano, D.A., and Levitt, M.D. 1987. Milk intolerance and microbe-containing dairy foods. J. Dairy Sci. 70: 397–406.

    Article  CAS  Google Scholar 

  • Seki, M.; Igarashi, Fukuda, Y.; Simamura, S.; Kawashima, T.; and Ogasa, K. 1978. The effect of Bifidobacterium cultured milk on the “regularity” among an aged group. Nutrition and Foodstuff. 31: 379–387. (in Japanese)

    Google Scholar 

  • Sekine, K.; Toida, T.; Saito, M.; Kuboyama, M.; Kawashima, T.; and Hashimoto, Y. 1985. A new morphologically characterized cell wall preparation (whole peptidoglycan) from Bifidobacterium infantis with a higher efficacy on the regression of an established tumor in mice. Cancer Res. 45: 1300–1307.

    CAS  Google Scholar 

  • Sellars, R.L. 1989. Health properties of yogurt. In Yogurt: Nutritional and Health Properties, R.C. Chandan, ed., pp. 115–144. McLean, VA: National Yogurt Association.

    Google Scholar 

  • Sellars, R.L. 1991. Acidophilus products. In Therapeutic Properties of Fermented Milks, R.K. Robinson, ed., pp. 81–116. New York: Elsevier Applied Science.

    Google Scholar 

  • Shackelford, L.A.; Rao, D.R.; Chawan, C.B.; and Pulusani, S.R. 1983. Effect of feeding fermented milk on the incidence of chemically induced colon tumors in rats. Nutr. Cancer 5: 159–164.

    Article  CAS  Google Scholar 

  • Siitonen, S.; Vapaatalo, H.; Salminen, S.; Gordin, A.; Saxelin, M.; Wikberg, R.; and Kirkkola, A.-L. 1990. Effect of Lactobacillus GG yogurt in prevention of antibiotic associated diarrhea. Ann. Medicine (Helinski) 22: 57–59.

    Article  CAS  Google Scholar 

  • Smith, M.; Sullivan, C.; and Goodman, N. 1991. Reactivity of milk cholesterol with bacterial cholesterol oxidases. J. Agric. Food Chem. 39: 2158–2162.

    Article  CAS  Google Scholar 

  • Tannock, G.W. 1983. Effect of dietary and environmental stress on the gastrointestinal microbiota. In Human Intestinal Microflora in Health and Disease, D.J. Hentges, ed., pp. 517–539. New York: Academic Press, Inc.

    Google Scholar 

  • Tannock, G.W. 1984. Control of gastrointestinal pathogens by normal flora. In Current Perspectives in Microbial Ecology, M.J. Klug and C.A. Reddy, eds., pp. 374–382. Washington, D.C.: Amer. Soc. Microbiol.

    Google Scholar 

  • Tannock, G.W. 1990. The microecology of Lactobacilli inhabiting the gastrointestinal tract. Adv. Microb. Ecol. 11: 147–171.

    Article  Google Scholar 

  • Thompson, L.U.; Jenkins D.J.A.; Amer, M.A.V.; Reichert, R.; Jenkins, A.; and Kamulsky, J. 1982. The effect of fermented and unfermented milks on serum cholesterol. Amer. J. Clin. Nutr. 36: 1106–1111.

    CAS  Google Scholar 

  • Truslow, W.W. 1986. Lactobacillus (sic) and fermented foods. J. Holistic Med. 8: 36–46.

    Google Scholar 

  • van’t Veer, P.; Dekker, J.M.; Lamers, J.W.J.; Kok, F.J.; Schouten, E.G.; Brants, H.A.M.; Sturmans, F; and Hermus, R.J.J. 1989. Consumption of fermented milk products and breast cancer: A case-control study in the Netherlands. Cancer Res. 49: 4020–4023.

    Google Scholar 

  • Wytock, D.H., and J.A. DiPalma. 1988. All yogurts are not created equal. Am. J. Clin. Nutr. 47: 454–457.

    CAS  Google Scholar 

  • Yamazaki, S.; Machii, K.; Tsuyuki, S.; Momose, H.; Kawashima, T.; and Ueda, K. 1985. Immunological responses to monoassociated Bifidobacterium longum and their relation to prevention of bacterial invasion. Immunology 56: 43–50.

    CAS  Google Scholar 

  • Zhang, X.B., and Ohta, Y. 1991a. In vitro binding of mutagenic pyrolyzates to lactic acid bacterial cells in human gastric juice. J. Dairy Sci. 74: 752–757.

    Article  CAS  Google Scholar 

  • Zhang, X.B. 1991b. Binding of mutagens by fractions of the cell wall skeleton of lactic acid bacteria on mutagens. J. Dairy Sci. 74: 1477–1481.

    Article  CAS  Google Scholar 

  • Zhang, X.B.; Ohta, Y.; and Hosono, A. 1990. Antimutagenicity and binding of lactic acid bacteria from a Chinese cheese to mutagenic pyrolyzates. J. Dairy Sci. 73: 2702–2710.

    Article  CAS  Google Scholar 

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Israel Goldberg

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© 1994 Springer Science+Business Media Dordrecht

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Sanders, M.E. (1994). Lactic Acid Bacteria as Promoters of Human Health. In: Goldberg, I. (eds) Functional Foods. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2073-3_14

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  • DOI: https://doi.org/10.1007/978-1-4615-2073-3_14

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  • Print ISBN: 978-1-4613-5861-9

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