Summary
There is a growing consensus on the beneficial effects of bifidobacteria in human health. It is now clear that bifidobacteria that exist in the large intestine are helpful for maintenance of human health and are far more important thanLactobacillus acidophilus as beneficial intestinal bacteria throughout human life. In other words, the reduction or disappearance of bifidobacteria in the human intestine would indicate an “unhealthy” state. Oral administration of bifidobacteria may be effective for the improvement of intestinal flora and intestinal environment, for the therapy of enteric and hepatic disorders, for stimulation of the immune response, and possibly for the prevention of cancer and slowing the aging process. However, for consistent and positive results further well-controlled studies are urgently needed.
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References
Cruickshank, J. 1925.Bacillus bifidus: its characters and isolation from the intestine of infants. J. Hyg. 24: 241–254.
Hotta, M., Y. Saito, S. Iwata, N. Yamashita, K. Sunakawa, T. Oikawa, R. Tanaka, K. Watanabe, H. Takayama, M. Yajima, S. Sekiguchi, S. Arai, T. Sakurai, and M. Mutai. 1987. Clinical effects ofBifidobacterium preparations on pediatric intractable diarrhea. Keio J. Med. 36: 298–314.
Kohwi, Y., Y. Hashimoto, and Z. Tamura. 1982. Antitumor and immunological adjuvant effect ofBifidobacterium infantis in mice. Bifidobacteria Microflora 1: 61–68.
Kohmoto, T., F. Fukui, H. Takaku, Y. Machida, M. Arai and T. Mitsuoka. 1988. Effect of isomalto-oligosaccharides on human fecal flora. Bifidobacteria Microflora 7: 61–69.
Koizumi, T., N. Mitsuya, T. Mukuta, S. Fujita, H. Ishizu, and H. Yoshioka. 1980. Effects of administration ofBifidobacterium preparation (BBG-02) on hepatic coma. Sogo Rinsho 29: 2473–2478 (in Japanese).
Mitsuoka, T. 1982. Recent trends in research on intestinal flora. Bifidobacteria Microflora 1: 3–24.
Mitsuoka, T. 1984. Taxonomy and ecology of bifidobacteria. Bifidobacteria Microflora 3: 11–28.
Mitsuoka, T. and K. Hayakawa. 1972. Die Faekalflora bei Menschen. I. Mitteilung: Die Zusammensetzung der Faekalflora der verschiedenen Altersgruppen Zbl. Bakt. Hyg., I. Abt. Orig. A 223: 333–342.
Mitsuoka, T., H. Hidaka and T. Eida. 1987. Effect of fructooligosaccharides on intestinal microflora. Die Nahrung 31: 5–6.
Mitsuoka, T. and K. Ohno. 1977. Die Faekalflora bei menschen. V. Mitteiling: Die Schwankungen in der Zusammensetsung der Faekalflora gesunder Erwachsener. Zbl. Bakt. Hyg., I. Abt. Orig. A 238: 228–236.
Mizutani, T. and T. Mitsuoka. 1980. Inhibitory effect of some intestinal bacteria on liver tumorigenesis in gnotobiotic C3H/He male mice. Cancer Lett. 11: 89–95.
Müting, D., W. Escherich, and J.P. Mayer. 1968. The effect ofBifidobacterium bifidum on intestinal bacterial flora and toxic protein metabolites in chronic liver diseases. Am. J. Proetol. 19: 336–342.
Orla-Jensen, S. 1924. La classification des bacteries lactiques. Lait 4: 468–474.
Sekine, K., T. Toida, M. Saito, M. Kuboyama, and Y. Hashimoto. 1985. A new morphologically characterized cell wall preparation (whole peptidoglycan) fromBifidobacterium infantis with a higher efficacy on the regression of an established tumor in mice. Cancer Res. 45: 1300–1307.
Tanaka, R., H. Takayama, M. Morotomi, T. Kuroshima, S. Ueyama, K. Matsumoto, A. Kuroda, and M. Mutai. 1983. Effects of adminstration of TOS andBifidobacterium breve 4006 on the human fecal flora. Bifidobacteria Microflora 2: 17–24.
Tissier, H. 1900. Recherches sur la flore intestinale normale et pathologique du nourisson, pp. 1–253. Thèse de Paris.
Tohyama, K., R. Tanaka, Y. Kobayashi, and M. Mutai. 1982. Relationship between the metabolic regulation of intestinal microflora by feedingBifidobacterium and host hepatic function. Bifidobacteria Microflora 1: 45–50.
Weiss, J.E. and L.F. Rettger. 1934.Lactobacillus bifidus. J. Bacteriol. 28: 501–527.
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Mitsuoka, T. Bifidobacteria and their role in human health. Journal of Industrial Microbiology 6, 263–267 (1990). https://doi.org/10.1007/BF01575871
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DOI: https://doi.org/10.1007/BF01575871