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Pharmacology of Locomotion in Chronic Spinal Cats

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Alpha and Gamma Motor Systems

Abstract

This short review will summarize some of the work we and others have performed in the field of pharmacology of locomotion in cats and indicate the potential benefits of such an approach in clinical situations where we believe that a rational locomotor pharmacotherapy can be developed.

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References

  • Baev, K. V. (1977). Rhythmic discharges in hindlimb motor nerves of the decerebrate, immobolized cat induced by intravenous injection of DOPA. Neurophysiol. 9, 165–167.

    Google Scholar 

  • Barbeau, H., Julien, C. & Rossignol, S. (1987). The effects of clonidine and yohimbine on locomotion and cutaneous reflexes in the adult chronic spinal cat. Brain Res. 437, 83–96.

    Article  PubMed  CAS  Google Scholar 

  • Barbeau, H., Chau, C. & Rossignol, S. (1993). Noradrenergic agonists and locomotor training affect locomotor recovery after cord transection in adult cats. Brain Res. Bull. 30, 387–393.

    Article  PubMed  CAS  Google Scholar 

  • Barbeau, H. & Rossignol, S. (1987). Recovery of locomotion after chronic spinalization in the adult cat. Brain Res. 412, 84–95.

    Article  PubMed  CAS  Google Scholar 

  • Barbeau, H. & Rossignol, S. (1990). The effects of serotonergic drugs on the locomotor pattern and on cutaneous reflexes of the adult chronic spinal cat. Brain Res. 514, 55–67.

    Article  PubMed  CAS  Google Scholar 

  • Barbeau, H. & Rossignol, S. (1991). Initiation and modulation of the locomotor pattern in the adult chronic spinal cat by noradrenergic, serotonergic and dopaminergic drugs. Brain Res. 546, 250–260.

    Article  PubMed  CAS  Google Scholar 

  • Barbeau, H. & Rossignol, S. (1994) Spinal cord injury: enhancement of locomotor recovery. Current Opinion in Neurology. 7, 517–524.

    Article  PubMed  CAS  Google Scholar 

  • Chau, C., Provencher, J., Lebel, F., Jordan, L., Barbeau, H. & Rossignol, S. (1994). Effects of intrathecal injection of NMDA receptor agonist and antagonist on locomotion of adult chronic spinal cats. Soc. Neurosci. Abstr. 20, 573.

    Google Scholar 

  • Douglas, J. R., Nogas, B. R., Dai, X. & Jordan, L. M. (1993). The effects of intrathecal administration of excitatory amino acid agonists and antagonists on the initiation of locomotion in the adult cat. J. Neurosci. 13, 990–1000.

    PubMed  CAS  Google Scholar 

  • Fleshman, J. W., Lev-Tov, A. & Burke, R. E. (1984). Peripheral and central control of flexor digitorium longus and flexor hallucis longus motoneurons: the synaptic basis of functional diversity. Exp. Brain Res. 54, 133–149.

    Article  PubMed  CAS  Google Scholar 

  • Forssberg, H. & Grillner, S. (1973). The locomotion of the acute spinal cat injected with clonidine i.v. Brain Res. 50, 184–186.

    Article  PubMed  CAS  Google Scholar 

  • Grillner, S. & Zangger, P. (1975). How detailed is the central pattern generation for locomotion?. Brain Res. 88, 367–371.

    Article  PubMed  CAS  Google Scholar 

  • Grillner, S. & Zangger, P. (1979). On the central generation of locomotion in the low spinal cat. Exp. Brain Res. 34, 241–261.

    Article  PubMed  CAS  Google Scholar 

  • Hinsey, J. C., Ranson, S. W. & Zeiss, F. R. (1931). Observations on reflex activity and tonicity in acute decapitate preparations with and without ephedrine. J. Comp. Neurol. 53, 401–407.

    Article  CAS  Google Scholar 

  • Jankowska, E., Jukes, M. G., Lund, S. & Lundberg, A. (1967a). The effect of DOPA on the spinal cord. 5. Reciprocal organization of pathways transmitting excitatory action to alpha motoneurones of flexors and extensors. Acta physiol. scand. 70, 369–388.

    Article  PubMed  CAS  Google Scholar 

  • Jankowska, E., Jukes, M. G., Lund, S. & Lundberg, A. (1967b). The effects of DOPA on the spinal cord. 6. Half centre organization of interneurones transmitting effects from the flexor reflex afferents. Acta physiol. scand. 70, 389–402.

    Article  PubMed  CAS  Google Scholar 

  • Pearson, K. G. & Rossignol, S. (1991). Fictive motor patterns in chronic spinal cats. J. Neurophysiol. 66, 1874–1887.

    PubMed  CAS  Google Scholar 

  • Rossignol, S., Barbeau, H. & Julien, C. (1986). Locomotion of the adult chronic spinal cat and its modification by monoaminergic agonists and antagonists. In Development and plasticity of the mammalian spinal cord, eds. Goldberger, M., Gorio, A. & Murray, M., pp. 323–345. Liviana Press, Padova.

    Google Scholar 

  • Rossignol, S. & Barbeau, H. (1993). Pharmacology of locomotion: an account of studies in spinal cats and spinal cord injured subjects. J. Am. Paraplegia Soc. 16, 190–196.

    PubMed  CAS  Google Scholar 

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© 1995 Springer Science+Business Media New York

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Rossignol, S., Chau, C., Barbeau, H. (1995). Pharmacology of Locomotion in Chronic Spinal Cats. In: Taylor, A., Gladden, M.H., Durbaba, R. (eds) Alpha and Gamma Motor Systems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1935-5_95

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  • DOI: https://doi.org/10.1007/978-1-4615-1935-5_95

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5793-3

  • Online ISBN: 978-1-4615-1935-5

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