Abstract
During embryonic development, the rudimentary layers that will become the pigment epithelium (PE) and the neural retina are brought into close proximity upon the collapse of the optic vesicles. At this developmental stage, the retina is morphologically undifferentiated and photoreceptor outer segments have not yet begun to form. The close apposition of the PE and photoreceptors prior to the time when outer segments first appear raises the possibility that the PE could be a source of signals that induce or regulate photoreceptor development and outer segment elaboration. Also, the observation that outer segment development is limited in the absence of the PE in most species suggests that interactions between these two cell types may be of fundamental importance for the structural and functional maturation of photoreceptors [1, 2, 3, 5, 13, 16, 19, 20, 26].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Adler R (1986) Developmental predetermination of the structural and molecular polarization of photoreceptor cells. Dev. Biol., 117: 520–527.
Adler R (1987) Nature and nurture in the differentiation of retinal photoreceptors and neurons. Cell Differ., 20: 183–188.
Adler R, Politi L (1989) Expression of a “ survival crisis” by normal and rd/rd mouse photoreceptor cells in vitro. In: LaVail MM, Anderson RE, Hollyfield JG (eds) Inherited and environmentally induced retinal degenerations, Alan R. Liss, Inc., New York, pp 169–181.
Anderson DH, Gué rin CJ, Erickson PA, Stern WH, Fisher SK (1986) Morphological recovery in the reattached retina. Invest. Ophthalmol. Vis. Sci., 27: 168–183.
Caffé AR, Visser H, Jansen HG, Sanyal S (1989) Histopathic differentiation of neonatal mouse retina in organ culture. Curr. Eye Res., 8: 1083–1092.
Defoe DM, Besharse JC, Fliesler SJ (1986) Tunicamycin-induced dysgenesis of retinal rod outer segment membranes. I. Quantitative freeze-fracture analysis. Invest. Ophthalmol. Vis. Sci., 27: 1595–1601.
Erickson PA, Fisher SK, Anderson DH, Stern WH, Borgula GA (1983) Retinal detachment in the cat: the outer nuclear and outer plexiform layers. Invest. Ophthalmol. Vis. Sci., 24: 927–942.
Faktorovich EG, Steinberg RH, Yasumura D, Matthes MT, LaVail MM (1990) Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor. Nature, 347: 83–86.
Fliesler SJ, Rayborn ME, Hollyfield JG (1985) Membrane morphogenesis in retinal rod outer segments: inhibition by tunicamycin. J. Cell Biol., 100: 574–587.
Fliesler SJ, Rayborn ME, Hollyfield JG (1986) Inhibition of oligosaccharide processing and membrane morphogenesis in retinal rod photoreceptor cells. Proc. Natl. Acad. Sci., 83: 6435–6439.
Gué rin CJ, Anderson DH, Fariss RN, Fisher SK (1989) Retinal reattachment of the primate macula. Invest. Ophthalmol. Vis. Sci., 30: 1708–1725.
Guérin CJ, Lewis GP, Fisher SK, Anderson DH (1993) Recovery of photoreceptor outer segment length and analysis of membrane assembly rates in regenerating primate photoreceptor outer segments. Invest. Ophthalmol. Vis. Sci., 34: 175–183.
Lahav M (1987) In vitro model of retinal photoreceptor differentiation. Trans. Am. Ophthalmol. Soc, 85: 600–638.
Lahiri D, Hollyfield JG (1992) Development of WGA-binding domains in the IPM of Xenopus laevis embryos. Invest. Ophthalmol. Vis. Sci. (Suppl.), 33: 815.
Lahiri D, Rayborn ME, Hollyfield JG (1991) Development of the IPM in Xenopus laevis embryos. Invest. Ophthalmol. Vis. Sci. (Suppl.)32: 1217.
LaVail MM, Hild W (1971) Histotypic organization of the rat retina in vitro. Z. Zellforsch, 114: 557–579.
Lewis GP, Erickson PA, Anderson DH, Fisher SK (1991) Opsin distribution and protein incorporation in photoreceptors after experimental retinal detachment. Exp. Eye Res., 53: 629–640.
Li L, Turner JE (1991) Optimal conditions for long-term photoreceptor cell rescue in RCS rats: The necessity for healthy RPE transplants. Exp. Eye Res., 52: 669–679.
Politi LE, Lahav M, Adler R (1988) Development of neonatal mouse retinal neurons and photoreceptors in low density cell culture. Invest. Ophthalmol. Vis. Sci., 29: 534–543.
Roof D, Hayes A, Adamian M, Marescalchi P, Heth C (1991) Photoreceptor development in rat neural retina-retinal pigment epithelium co-cultures. Invest. Ophthalmol. Vis. Sci., 32: 1148.
Stiemke MM, Hollyfield JG (1994) Outer segment disc membrane assembly in the absence of the pigment epithelium: The effect of exogenous sugars. Dev. Brain Res., 80: 285–289.
Stiemke MM, Landers RA, Al-Ubaidi MR, Hollyfield JG (1994) Photoreceptor outer segment development in Xenopus laevis: Influence of the pigment epithelium. Dev. Biol., 162: 169–180.
Takeda Y, Yamaguchi K, Yamada K, Matthes MT (1993) Photoreceptor rescue of Royal College of Surgeons (RCS) rat retina by human subretinal fluid. Invest. Ophthalmol. Vis. Sci., 34: 1097.
Travis GH, Sutcliffe JG, Bok D (1991) The retinal degeneration slow (rds) gene product is a photoreceptor disc membrane-associated glycoprotein. Neuron, 6: 61–70.
Ulshafer RJ, Allen CB, Fliesler SJ (1986) Tunicamycin-induced dysgenesis of retinal rod outer segment membranes. II. A scanning electron microscopy study. Invest. Ophthalmol. Vis. Sci., 27: 1587–1594.
Watanabe T, Raff MC (1990) Rod photoreceptor development in vitro: intrinsic properties of proliferating neuroepithelial cells change as development proceeds in the rat retina. Neuron, 2: 461–467.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Stiemke, M.M., Hollyfield, J.G. (1995). Effect of Sugars on Photoreceptor Outer Segment Assembly. In: Anderson, R.E., LaVail, M.M., Hollyfield, J.G. (eds) Degenerative Diseases of the Retina. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1897-6_15
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1897-6_15
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5774-2
Online ISBN: 978-1-4615-1897-6
eBook Packages: Springer Book Archive