Abstract
When embryos attach to the luminal epithelium in the rat uterus they somehow induce differentiation of the stromal cells underlying the attachment site, giving rise to an enormous increase in the size of the stromal cell compartment through both cell proliferation and cell growth. This reaction, decidualization, is localized to areas of embryo attachment (reviewed in DeFeo, 1967). Both attachment of the embryo to the luminal epithelium and differentiation of the stromal cells in response to embryo attachment require conditioning of the uterus with steroid hormones (Psychoyos, 1973). If the uterus is hormonally prepared, decidualization can be obtained using an intraluminal traumatic or chemical artificial stimulus. In response to these stimuli stromal cells along the entire length of the uterus will differentiate (DeFeo, 1967).
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References
Achten, S. and Doerfler, W., 1986, Characterization of a member of the highly repeated long interspersed rat DNA framily with long open reading frames, J. Mol Biol. 192: 489–502.
Bitton-Casimiri, V., Rath, N.C., and Psychoyos, A., 1977, A simple method for separation and culture of rat uterine epithelial cells, J. Endocr. 73: 537–538.
Bladon, T.S., Fregeau, C.J., McBurney, M.W., 1990, Synthesis and processing of small B2 transcripts in mouse embryonal carcinoma cells, Mol. Cell. Biol. 10: 4058–4067.
Clemens, M.J., 1987, A potential role for RNA transcribed from B2 repeats in the regulation of mRNA stability, Cell 49: 157–158.
Carey, M.F. and Singh, K., 1988, Enhanced B2 transcription in simian virus 40-transformed cells is mediated through the formation of RNA polymerse II transcription complexes on previously inactive genes, Biochemistry 85: 7059–7063.
De Feo, V.J., 1967, Decidualization, in: “Cellular Biology of the Uterus,” R. M. Wynn, ed., Appleton-Century-Crofts, N.Y., pp. 191–290.
De Strooper, B., Van Leuven, F., and Van Den Berghe, H., 1991, The amyloid beta protein precursor or proteinase nexin II from mouse is closer related to its human homolog than previously reported, Biochim. Biophys. Acta 1129: 141–143.
Edwards, D.R., Parfett, C.L.J., and Denhardt, D.T., 1985, Transcriptional regulation of two serum-induced RNAs in mouse fibroblasts: equivalence of one species to B2 repetitive elements, Mol. Cell Biol. 5: 3280–3288.
Glasser, S.R. and Clark, J.H., 1975, A determinant role for progesterone in the development of uterine sensitivity to decidualization and ovo-implantation, in “Developmental Biology of Reproduction,” C. L. Markert, J. Papaconstantinou, Eds., Academic Press, N.Y., pp. 311–345.
Higashiyama, S., Abraham, J.A., Miller, J., Fiddes, J.C., and Klagsbrun, M., 1991, A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF, Science 251: 936–939.
Higashiyama, S., Lau, K., Besner, G.E., Abraham, J.A., and Klagsbrun, M., 1992, Structure of Heparin-binding EGF-like Growth Factor, J. Biol. Chem. 267: 6205–6212.
Huet-Hudson, Y.M., Andrews, G.K., and Dey, S.K., 1989, Cell type-specific localization of c-Myc protein in the mouse uterus: modulation by steroid hormones and analysis of the periimplantation period, Endocrinol. 125: 1683–1690.
Kang, J., Lemaire, H-G., Unterbeck, A., Salbaum, M., Masters, C.L., Grzeschik, K-H., Multhaup, G., Beyreuther, K., and Muller-Hill, B., 1987, The precursor of Alzheimer’s disease amyloid A4 protein resembles a cell-surface receptor, Nature 325: 733–736.
Klagsbrun, M., 1990, The affinity of fibroblast growth factors (FGFs) for heparin; FGF-heparan sulfate interactions in cells and extracellular matrix, Curr. Opin. Cell Biol. 2: 857–863.
Kleinfeld, R.G. and O’Shea, J.D., 1983, Spatial and temporal patterns of deoxyribonucleic acid synthesis and mitosis in the endometrial stroma during decidualization in the pseudopregnant rat, Biol. Reprod 28: 691–702.
Kohnoe, S., Maehara, Y., and Endo, H., 1987, A systematic survey of fepetitive sequences abundantly expressed in rat tumors, Biochim. Biophys. Acta 909: 107–114.
Lania, L., Pannuti, A., La Mantia, G., and Basilico, C., 1987, The transcription of B2 repeated sequences is regulated during the transition from quiescent to proliferative state in cultured rodent cells, FEBS Lett. 219: 400–404.
Lejeune, B., Van Hoeck, J., and Leroy, F., 1981, Transmitter role of the luminal uterine epithelium in the induction of decidualization in rats, J. Reprod. Fert. 61: 235–240.
Martin, L. and Finn, C.A., 1968, Hormonal regulation of cell division in epithelial and connective tissue of the mouse uterus, J. Endocrinol. 41: 363–371.
Murphy, D., Brickell, P.M., Latchman, D.S., Willison, K., and Rigby P.W.J., 1983, Transcripts regulated during normal embryonic development and oncogenic transformation share a repetitive element, Cell 35: 865–871.
O’Grady, J.E. and Bell, S.C., 1977, The role of the endometrium in blastocyst implantation, in “Development in Mammals, Vol. I,” M.H. Johnson, Ed., pp. 165-243.
Oltersdorf, T., Fritz, L.C., Schenk, D.B., Lieberburg, I., Johnson-Wood, K.L., Beattie, E.C., Ward, P.J., Blacher, R.W., Dovey, H.F., and Sinha, S., 1989, The secreted form of the Alzheimer’s amyloid precursor protein with te Kunitz domain is protease nexin-II, Nature 341: 144–147.
Psychoyos, A., 1973, Hormonal control of implantation, Vitam. Horm. 31: 201–256.
Rogers, J.H., 1985, The origin and evolution of retroposons, Int. Rev. Cytol. 91: 187–279.
de Sauvage, F. and Octave, J-N., 1989, A Novel mRNA of the A4 amyloid precursor gene coding for a possibly secreted protein, Science 245: 651–653.
Schubert, D., LaCorbiere, M., Saitoh, T., and Cole, G., 1989, Characterization of an amyloid beta precursor protein that binds heparin and contains tyrosine sulfate, Proc. Natl. Acad. Sci. USA 86: 2066–2069.
Singh, K., Carey, M., Saragosti, S., and Botchan, M., 1985, Expression of enhanced levels of small RNA polymerase III transcripts encoded by the B2 repeats in simian virus 40-transformed mouse cells, Nature 314: 553–556.
Taylor, K.D. and Piko, L., 1987, Patterns of mRNA prevalence and expression of B1 and B2 transcripts in early mouse embryos, Development 101: 877–892.
Wewer, U.M., Damjanov, A., Weiss, J., Liotta, L.A., and Damjanov, I., 1986, Mouse endometrial stromal cells produce basement-membrane components, Differentiation 32: 49–58.
Yoshikai, S., Sasaki, H., Doh-ura, K., Furuya, H., and Sakaki, Y., 1990, Genomic organization of the human amyloid beta-protein precursor gene, Gene 87: 257–263.
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Mulholland, J., Roy, D., Glasser, S. (1994). Progesterone Directed Gene Expression in Rat Uterine Stromal Cells. In: Glasser, S.R., Mulholland, J., Psychoyos, A. (eds) Endocrinology of Embryo-Endometrium Interactions. Reproductive Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1881-5_4
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DOI: https://doi.org/10.1007/978-1-4615-1881-5_4
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