Skip to main content
SpringerLink
Log in

Involvement of Local Mediators in Blastocyst Implantation

  • Chapter
Endocrinology of Embryo-Endometrium Interactions

Part of the book series: Reproductive Biology ((RBIO))

Abstract

In most mammalian species, the earliest macroscopically identifiable event in the process of blastocyst implantation is an increase in endometrial vascular permeability which is localized to implantation sites (Psychoyos, 1973). In the rat this increase in permeability can be first detected some 20–24 hours before trophoblastic invasion of the endometrium (Psychoyos, 1973). In those species in which stimulation of the uterus results in decidualization, an increase in endometrial vascular permeability precedes the decidualization; depending on the nature of the stimulus applied, the permeability response and subsequent decidualization may be localized or generalized.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Acker, G., Braquet, P., and Mencia-Huerta, J.M., 1989, Role of platelet-activating factor (PAF) in the initiation of the decidual reaction in the rat, J. Reprod. Fertil. 85:623–629.

    Article  PubMed  CAS  Google Scholar 

  • Alecozay, A.A., Harper, M.J.K., Schenken, R.S., and Hanahan, D.J., 1991, Paracrine interactions between platelet-activating factor and prostaglandins in hormonally-treated human luteal phase endometrium in vitro, J. Reprod. Fertil. 91:301–312.

    Article  PubMed  CAS  Google Scholar 

  • Amiel, M.L., Duquenne, C., Benvenista, J., and Testart, J., 1989, Platelet aggregating activity in human embryo culture medium free of PAF-acether, Hum. Reprod. 4:327–330.

    PubMed  CAS  Google Scholar 

  • Ando, M., Suginami, H., and Matsuura, S., 1990, Pregnancy suppression by a structurally related antagonist for platelet activating factor, CV-6290, in mice, Asia Oceania J. Obstet. Gynaecol. 16:283–290.

    Article  PubMed  CAS  Google Scholar 

  • Angle, M.J., Jones, M.A., McManus, L.M., Pinckard, R.N., and Harper, M.J.K., 1988, Platelet-activating factor in the rabbit uterus during early pregnancy, J. Reprod. Fertil. 83:711–722.

    Article  PubMed  CAS  Google Scholar 

  • Bach, M.K., Bowman, B.J., Brashler, J.R., Fitzpatrick, F.A., Griffin, R.L., Johnson, H.G., Major, N.J., McGuire, J.C., McNee, M.L., Richards, I.M., Smith, H.W., Smith, R.J., Speziale, S.C., and Sun, F.F. 1985, Piriprost: a selective inhibitor of leukotriene synthesis, Adv. Prostagl. Thrombox. Leukotr. Res. 15:225–227.

    CAS  Google Scholar 

  • Battye, K.M., Ammit, A.J., O’Neill, C., and Evans, G., 1991, Production of platelet-activating factor by the pre-implantation sheep embryo, J. Reprod. Fertil. 93:507–514.

    Article  PubMed  CAS  Google Scholar 

  • Bazer, F.W., Vallet, J.L., Harney, J.P., Gross, T.S., and Thatcher, W.W., 1989, Comparative aspects of maternal recognition of pregnancy between sheep and pigs, J. Reprod. Fertil., Suppl. 37:85–89.

    CAS  Google Scholar 

  • Brenner, R.M., West, N.B., and McClellan, M.C. 1990, Estrogen and progestin receptors in the reproductive tract of male and female primates, Biol. Reprod. 42:11–19.

    Article  PubMed  CAS  Google Scholar 

  • Cejic, S.S., and Kennedy, T.G., 1991a, Effects of piriprost (U-60, 257B) and leukotrienes on alkaline phosphatase activity of rat endometrial stromal cells in vitro, Prostaglandins 42:163–177.

    PubMed  CAS  Google Scholar 

  • Cejic, S.S., and Kennedy, T.G., 1991b, Examination of the effects of piriprost (U-60, 257B) on alkaline phosphatase activity in rat endometrial stromal cells in vitro, Prostaglandins 42:179–189.

    PubMed  CAS  Google Scholar 

  • Chegini, N., and Rao, C.V., 1988a, Quantitative light microscopic autoradiographic study on [3H] leukotriene C4 binding to nonpregnant bovine uterine tissue, Endocrinology 122:1732–1736.

    Article  PubMed  CAS  Google Scholar 

  • Chegini, N., and Rao, C.V., 1988b, The presence of leukotriene C4-and prostacyclin-binding sites in nonpregnant human uterine tissue, J. Clin. Endocrinol. Metab. 66:76–87.

    Article  PubMed  CAS  Google Scholar 

  • Chegini, N., Rao, C.V., Wakim, N., and Sanfilippo, J., 1986, Prostaglandin binding to different cell types of human uterus: quantitative light microscope autoradiographic study, Prostaglandins Leukotrienes Med. 22:129–138.

    Article  CAS  Google Scholar 

  • Cherny, R.A., and Findlay, J.K., 1990, Separation and culture of ovine endometrial epithelial and stromal cells: evidence of morphological and functional polarity, Biol. Reprod. 43:241–250.

    Article  PubMed  CAS  Google Scholar 

  • Collier, M., O’Neill, C., Ammit, A.J., and Saunders, D.M., 1988, Biochemical and pharmacological characterization of human embryo-derived platelet-activating factor, Hum. Reprod. 3:993–998.

    PubMed  CAS  Google Scholar 

  • Collier, M., O’Neill, C., Ammit, A.J., and Saunders, D.M., 1990, Measurement of human embryo-derived platelet-activating factor (PAF) using a quantitative bioassay of platelet aggregation, Hum. Reprod. 5:323–328.

    PubMed  CAS  Google Scholar 

  • Cushman, D.W., and Cheung, H.S., 1971, Concentrations of angiotensin-converting enzyme in tissues of the rat, Biochim. Biophys. Acta 250:261–265.

    Article  PubMed  CAS  Google Scholar 

  • Deboben, A., Inagami, T., and Ganten, D., 1983, Tissue renin, in “Hypertension, Pathophysiology and Treatment”, J. Genest, O. Kuchel, P. Hamet, and M. Cantin, eds., McGraw Hill, New York, pp. 194–209.

    Google Scholar 

  • Dey, S.K., and Johnson, D.C., 1987, Embryonic signals in pregnancy, Ann. NY Acad. Sci. 476:49–62.

    Article  Google Scholar 

  • Dey, S.K., Johnson, D.C., Pakrasi, P.L., and Liehr, J.G., 1986, Estrogens with reduced catechol-forming capacity fail to induce implantation in the rat, Proc. Soc. Exp. Biol. Med. 181:215–218.

    PubMed  CAS  Google Scholar 

  • Enders, A.C., and Schlafke, S., 1979, Comparative aspects of blastocyst-endometrial interactions at implantation, CIBA Found. Symp. 64:3–22.

    Google Scholar 

  • Evans, C.A., and Kennedy, T.G., 1980, Blastocyst implantation in ovariectomized, adrenalectomized hamsters treated with inhibitors of steroidogenesis during the pre-implantation period, Steroids 36:41–52.

    Article  PubMed  CAS  Google Scholar 

  • Ferrando, G., and Nalbandov, A.V., 1968, Relative importance of histamine and estrogen on implantation in rats, Endocrinology 83:933–937.

    Article  PubMed  CAS  Google Scholar 

  • Finn, C.A., and Pope, M.D., 1991, Infiltration of neutrophil polymorphonuclear leucocytes into the endometrial stroma at the time of implantation of ova and the initiation of the oil decidual cell reaction in mice, J. Reprod. Fertil 91:365–369.

    Article  PubMed  CAS  Google Scholar 

  • Flint, A.P.F., Burton, R.D., Gadsby, J.E., Saunders, P.T.K., and Heap, R.B., 1979, Blastocyst estrogen synthesis and the maternal recognition of pregnancy, CIBA Found. Symp. 64:209–228.

    CAS  Google Scholar 

  • Gupta, A., Huet, Y.M., and Dey, S.K., 1989, Evidence for prostaglandins and leukotrienes as mediators of phase I of estrogen action in implantation in the mouse, Endocrinology 124:546–548.

    Article  PubMed  CAS  Google Scholar 

  • Hammerström, S., 1983, Leukotrienes, Annu. Rev. Biochem. 52:355–377.

    Article  Google Scholar 

  • Harper, M.J.K., Dowd, D., and Elliott, A.S.W., 1969, Implantation and embryonic development in the ovariectomized-adrenalectomized hamster, Biol. Reprod. 1:253–257.

    Article  PubMed  CAS  Google Scholar 

  • Hoversland, R.C., Dey, S.K., and Johnson, D.C., 1982, Catechol estradiol induced implantation in the mouse, Life Sci. 30:1801–1804.

    Article  PubMed  CAS  Google Scholar 

  • Jacobs, A.L., Decker, G.L., Glasser, S.R., Julian J., and Carson, D.D., 1990, Vectorial secretion of prostaglandins by polarized rodent uterine epithelial cells, Endocrinology 126:2125–2136.

    Article  PubMed  CAS  Google Scholar 

  • Kantor, B.S., Dey, S.K., and Johnson, D.C., 1985, Catechol estrogen induced initiation of implantation in the delayed implanting rat, Acta Endocrinol. 109:418–422.

    PubMed  CAS  Google Scholar 

  • Kasamo, M., Brandt, M., Ishikawa, M., Shimizu, T., and Harper, M.J.K., 1992, In vitro prostaglandin release from and platelet-activating factor accumulation in isolated endometrial cells from pregnant and pseudopregnant rabbits, Biol. Reprod. 46:829–845.

    Article  PubMed  CAS  Google Scholar 

  • Kennedy, T.G., 1983, Embryonic signals and the initiation of blastocyst implantation, Aust. J. Biol. Sci. 36:531–543.

    PubMed  CAS  Google Scholar 

  • Kennedy, T.G., 1990, Eicosanoids and blastocyst implantation, in “Eicosanoids in Reproduction”, M.D. Mitchell, ed., CRC Press, Boca Raton, pp. 123–138.

    Google Scholar 

  • Kennedy, T.G., and Armstrong, D.T., 1981, The role of prostaglandins in endometrial vascular changes at implantation, in “Cellular and Molecular Aspects of Implantation,” S.R. Glasser and D.W. Bullock, eds., Plenum, New York, pp. 349–363.

    Chapter  Google Scholar 

  • Kennedy, T.G., and Doktorcik, P.E., 1988, Effects of analogues of prostaglandin E2 and F2α on the decidual cell reaction in the rat, Prostaglandins 35:207–219.

    PubMed  CAS  Google Scholar 

  • Kennedy, T.G., and Lukash, L.A., 1982, Induction of decidualization in rats by the intrauterine infusion of prostaglandins, Biol. Reprod. 27:253–260.

    Article  PubMed  CAS  Google Scholar 

  • Kennedy, T.G., Martel, D., and Psychoyos, A., 1983, Endometrial prostaglandin E2 binding during the estrous cycle and its hormonal control in ovariectomized rats, Biol. Reprod. 29:565–571.

    Article  PubMed  CAS  Google Scholar 

  • Kennedy, T.G., Squires, P.M. and Yee, G.M., 1989, Mediators involved in decidualization, in “Blastocyst Implantation,” K. Yoshinaga, ed., Serono Symposia, Boston, pp. 135-143.

    Google Scholar 

  • Korach, K.S., Horigoma, T., Tomooka, Y., Yamashita, S., Newbold, R.R., and McLachlan, J.A., 1988, Immunodetection of estrogen receptor in epithelial and stromal tissues of neonatal mouse uterus, Proc. Natl. Acad. Sci. USA 85:3334–3337.

    Article  PubMed  CAS  Google Scholar 

  • Kudolo, G.B., and Harper, M.J.K., 1989, Characterization of platelet-activating factor binding sites on uterine membranes from pregnant rabbits, Biol. Reprod. 41:587–603.

    Article  PubMed  CAS  Google Scholar 

  • Kudolo, G.B., Kasamo, M., and Harper, M.J.K., 1991, Autoradiographic localization of platelet-activating factor (PAF) binding sites in the rabbit endometrium during the peri-implantation period, Cell Tiss. Res. 265:231–241.

    Article  CAS  Google Scholar 

  • Lejeune, B., VanHoeck, J., and Leroy, F., 1981, Transmitter role of the luminal uterine epithelium in the induction of decidualization in rats, J. Reprod. Fertil. 61:235–240.

    Article  PubMed  CAS  Google Scholar 

  • Lin, S.-Y., and Goodfriend, T.L., 1970, Angiotensin receptors, Am. J. Physiol. 218:1319–1328.

    PubMed  CAS  Google Scholar 

  • Malathy, P.V., Cheng, H.C., and Dey, S.K., 1986, Production of leukotrienes and prostaglandins in the rat uterus during periimplantation period, Prostaglandins 32:605–614.

    PubMed  CAS  Google Scholar 

  • Martel, D., Kennedy, T.G., Monier, M.N., and Psychoyos, A., 1985, Failure to detect specific binding sites for prostaglandin F-2α in membrane preparations from rat endometrium, J. Reprod. Fertil. 75:265–274.

    Article  PubMed  CAS  Google Scholar 

  • Milligan, S.R., and Finn, C.A., 1990, Failure of platelet-activating factor (PAF-acether) to induce decidualization in mice and failure of antagonists of PAF to inhibit implantation, J. Reprod. Fertil. 88:105–112.

    Article  PubMed  CAS  Google Scholar 

  • Moulton, B.C., and Russell, P.T., 1989, Arachidonic acid in uterine phospholipid during early pregnancy and following hormone treatment, Biol. Reprod. 41:821–826.

    Article  PubMed  CAS  Google Scholar 

  • Naruse, M., Naruse, K., Kurimoto, F., Sakurai, H., Yoshida, S., Toma, H., Ishii, T., Obana, K., Demura, H., Inagami, T., and Shizume, K., 1985, Evidence for the existence of des-asp1-angiotensin II in human uterine and adrenal tissues, J. Clin. Endocrinol. Metabl. 61:480–483.

    Article  CAS  Google Scholar 

  • O’Neill, C., 1985, Partial characterization of the embryo-derived platelet-activating factor in mice, J. Reprod. Fertil. 75:375–380.

    Article  PubMed  Google Scholar 

  • O’Neill, C., Gidley-Baird, A.A., Pike, I.L., and Saunders, D.M., 1987, Use of a bioassay for embryo-derived platelet-activating factor as a means of assessing quality and pregnancy potential of human embryos, Fertil. Steril. 47:969–975.

    PubMed  Google Scholar 

  • Orlando-Mathur, C.E., and Kennedy, T.G., 1993, An investigation into the role of neutrophils in decidualization and early pregnancy in the rat, Biol. Reprod. 48:1258–1265.

    Article  PubMed  CAS  Google Scholar 

  • Pakrasi, P.L., and Dey, S.K., 1985, Evidence for an inverse relationship between cyclooxygenase and lipoxygenase pathways in the pregnant rabbit endometrium, Prostaglandins Leukotrienes Med. 18:347–352.

    Article  CAS  Google Scholar 

  • Pakrasi, P.L., Becka, R., and Dey, S.K., 1985, Cyclooxygenase and lipoxygenase pathways in the preimplantation rabbit uterus and blastocyst, Prostaglandins 29:481–495.

    PubMed  CAS  Google Scholar 

  • Parr, M.B., Parr, E.L., Munaretto, K., Clark, M.R., and Dey, S.K., 1988, Immunohistochemical localization of prostaglandin synthase in the rat uterus and embryo during the peri-implantation period, Biol. Reprod. 38:333–343.

    Article  PubMed  CAS  Google Scholar 

  • Prasad, M.R.N., Orsini, M.W., and Meyer, R.K., 1960, Nidation in progesterone-treated, estrogen-deficient hamsters, Masocricetus auratus (Waterhouse), Proc. Soc. Exp. Biol. Med. 104:48–51.

    PubMed  CAS  Google Scholar 

  • Psychoyos, A., 1973, Endocrine control of egg implantation, in “Handbook of Physiology,” R.O. Greep, E.B. Astwood and S.R. Geiger, eds., Sect. 7, Vol. II, Part 2, American Physiological Society, Bethesda, pp. 187–215.

    Google Scholar 

  • Rees, M.C.P., DiMarzo, V., Tippins, J.R., Morris, H.R., and Turnbull, A.C., 1987, Leukotriene release by endometrium and myometrium throughout the menstrual cycle and menorrhagia, J. Endocrinol. 113:291–295.

    Article  PubMed  CAS  Google Scholar 

  • Rogers, P.A.W., Macpherson, A.M, and Beaton, L., 1992, Reduction in endometrial neutrophils in proximity to implanting rat blastocysts, J. Reprod. Fertil. 96:283–288.

    Article  PubMed  CAS  Google Scholar 

  • Ryan, J.P., Spinks, N.R., O’Neill, C., Ammit, A.J., and Wales, R.G., 1989, Platelet activating factor (PAF) production by mouse embryos in vitro and its effect on embryonic metabolism, J. Cell. Biochem. 40:387–395.

    Article  PubMed  CAS  Google Scholar 

  • Smal, M.A., Dziadek, M., Cooney, S.J., Attard, M., and Baldo, B.A., 1990, Examination for platelet-activating factor production by preimplantation mouse embryos using a specific radioimmunoassay, J. Reprod. Fertil. 90:419–425.

    Article  PubMed  CAS  Google Scholar 

  • Smith, S.M., Holm-Rutili, L., Perry, M.A., Grisham, M.B., Arfors, K.-E., Granger, D.N., and Kvietys, P.R., 1987, Role of neutrophils in hemorrhagic shock-induced gastric mucosal injury in the rat, Gastroenterology 93:466–471.

    PubMed  CAS  Google Scholar 

  • Snabes, M.C., and Harper, M.J.K., 1984, Site of action of indomethacin on implantation in the rabbit, J. Reprod. Fertil. 71:559–565.

    Article  PubMed  CAS  Google Scholar 

  • Spinks, N.R., and O’Neill, C., 1988, Antagonists of embryo-derived platelet-activating factor prevent implantation of mouse embryos, J. Reprod. Fertil. 84:89–98.

    Article  PubMed  CAS  Google Scholar 

  • Spinks, N.R., Ryan, J.P., and O’Neill, C., 1990, Antagonists of embryo-derived platelet-activating factor act by inhibiting the ability of the mouse embryo to implant, J. Reprod. Fertil. 88:241–248.

    Article  PubMed  CAS  Google Scholar 

  • Squires, P.M., and Kennedy, T.G., 1992, Evidence for a role for a uterine renin-angiotensin system in decidualization in rats, J. Reprod. Fertil. 95:791–802.

    Article  PubMed  CAS  Google Scholar 

  • Squires, P.M., Dixon, S.J., and Kennedy, T.G., 1991, Platelet activating factor increases cytosolic free Ca2+ in rat endometrial cells from uteri sensitized for implantation, Proc. Can. Fed. Biol. Soc. 34:722 (Abstr.).

    Google Scholar 

  • Squires, P.M., Dixon, S.J., and Kennedy, T.G., 1993, Maximal decidualization in rats requires both Ca2+ mobilization and increased prostaglandin production: evidence for involvement of angiotensin II, J. Reprod. Fertil., in press.

    Google Scholar 

  • Tawfik, O.W., and Dey, S.K., 1988, Further evidence for role of leukotrienes as mediators of decidualization in the rat, Prostaglandins 35:279–286.

    Google Scholar 

  • Tawfik, O.W., Huet, Y.M., Malathay, P.V., Johnson, D.C., and Dey, S.K., 1987, Release of prostaglandins and leukotrienes from the rat uterus is an early estrogenic response, Prostaglandins 34:805–815.

    PubMed  CAS  Google Scholar 

  • Vane, J.R., 1971, Inhibition of prostaglandin synthesis as a mechanism of action of aspirin-like drugs, Nature, New Biol. 231:232–235.

    CAS  Google Scholar 

  • Wallace, J.L., Keenan, C.M., and Granger, D.N., 1990, Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process, Am J. Physiol. 259:G462–G467.

    PubMed  CAS  Google Scholar 

  • Yasuda, K., Satouchi, K., and Saito, K., 1986, Platelet-activating factor in normal rat uterus, Biochem. Biophys. Res. Commun. 138:1231–1236.

    Article  PubMed  CAS  Google Scholar 

  • Yee, G.M., and Kennedy, T.G., 1988, Stimulatory effects of prostaglandins upon endometrial alkaline phosphatase activity during the decidual cell reaction in the rat, Biol. Reprod. 38:1129–1136.

    Article  PubMed  CAS  Google Scholar 

  • Yee, G.M., and Kennedy, T.G., 1991, Role of adenosine 3′,5′-monophosphate in mediating the effect of prostaglandin E2 on decidualization in vitro, Biol. Reprod. 45:163–171.

    Article  PubMed  CAS  Google Scholar 

  • Yee, G.M., Squires, P.M., Cejic, S.S., and Kennedy, T.G., 1993, Lipid mediators of implantation and decidualization, J. Lipid Med. 6:525–534.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Obstetrics & Gynaecology and of Physiology, The University of Western Ontario, London, ON, N6A 5A5, Canada

    Thomas G. Kennedy

Authors
  1. Thomas G. Kennedy
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Baylor College of Medicine, Houston, Texas, USA

    Stanley R. Glasser  & Joy Mulholland  & 

  2. Hôpital Bicêtre, Bâtiment INSERM Gregory Pincus, Bicêtre, France

    Alexandre Psychoyos

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Science+Business Media New York

About this chapter

Cite this chapter

Kennedy, T.G. (1994). Involvement of Local Mediators in Blastocyst Implantation. In: Glasser, S.R., Mulholland, J., Psychoyos, A. (eds) Endocrinology of Embryo-Endometrium Interactions. Reproductive Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1881-5_15

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-1881-5_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5766-7

  • Online ISBN: 978-1-4615-1881-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation