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Transcription Factors, Cofactors and Target Genes Mediating Prolactin Signals

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Prolactin

Part of the book series: Endocrine Updates ((ENDO,volume 12))

Abstract

More than 300 different biological functions have been ascribed to prolactin (PRL) in vertebrates. They comprise six areas of biological regulation: water and electrolyte balance, growth and development, endocrinology and metabolism, brain and behavior, reproduction, immunoregulation and protection (for review see 1). PRL influences these processes via the regulation of gene expression in various tissues. The multitude of processes regulated in different tissues suggests differential modes of action in individual target cells, but many of these mechanisms remain undefined. PRL may affect gene expression directly, for example through transcriptional control, or may do so by indirect mechanisms involving other cellular processes such as regulation of mRNA stability, protein synthesis or secondary modifications of proteins.

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  1. Georg-Speyer-Haus, Institute for Biomedical Research, Paul Ehrlich Str. 42-44, Frankfurt am Main, D-60596, Germany

    Carrie S. Shemanko & Bernd Groner

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  1. Carrie S. Shemanko
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  2. Bernd Groner
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  1. University of Cincinnati, USA

    Nelson D. Horseman

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© 2001 Springer Science+Business Media New York

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Shemanko, C.S., Groner, B. (2001). Transcription Factors, Cofactors and Target Genes Mediating Prolactin Signals. In: Horseman, N.D. (eds) Prolactin. Endocrine Updates, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1683-5_19

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  • DOI: https://doi.org/10.1007/978-1-4615-1683-5_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5676-9

  • Online ISBN: 978-1-4615-1683-5

  • eBook Packages: Springer Book Archive

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