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Soluble Factors Important for Pancreas Development

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Molecular Basis of Pancreas Development and Function

Part of the book series: Endocrine Updates ((ENDO,volume 11))

Abstract

The pancreas belongs to a family of organs such as the kidney, the lung and the mammary gland, whose development depends on inductive interactions between an epithelium and a mesenchyme. These interactions control proliferation, branching and differentiation of the epithelial cells. Interactions between mesenchymal and epithelial cells are mediated, at least in part, by soluble, diffusible factors. While some of soluble factors that control development of epithelial cells of the lung or the kidney have been identified (1,2), the soluble factors implicated in pancreatic development are less well known. From a theoretical point of view, soluble factors could control different crucial events during pancreatic development: 1) proliferation of immature epithelial cells, 2) their differentiation into endocrine or exocrine cells, and 3) the association of endocrine cells to form islets of Langerhans. These different events are summarized in Figure 1. In the present review, we concentrate on three families of soluble factors that are implicated in pancreatic development. These soluble factors are: ligands for tyrosine kinase receptors such as members of the Fibroblast Growth Factor (FGF) family or members of the Epidermal Growth Factor (EGF) family and members of the Transforming Growth Factor (TGF) superfamily.

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Authors and Affiliations

  1. INSERM U457, Hospital R. Debré, 48 Bd Sérurier, 75019 Paris, France

    Raphael Scharfmann Ph.D. & Paul Czernichow M.D.

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  1. Raphael Scharfmann Ph.D.
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  2. Paul Czernichow M.D.
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Editors and Affiliations

  1. Laboratory of Molecular Endocrinology, Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA

    Joel F. Habener M.D.

  2. Department of Medicine, Clinical and Molecular Endocrinology, New York University Medical Center, New York, NY

    Mehboob A. Hussain M.D.

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Scharfmann, R., Czernichow, P. (2001). Soluble Factors Important for Pancreas Development. In: Habener, J.F., Hussain, M.A. (eds) Molecular Basis of Pancreas Development and Function. Endocrine Updates, vol 11. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1669-9_9

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