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An Historical and Phylogenetic Perspective of Islet-Cell Development

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Molecular Basis of Pancreas Development and Function

Part of the book series: Endocrine Updates ((ENDO,volume 11))

Abstract

Before the discovery of insulin the diagnosis of diabetes mellitus was equivalent to being sentenced to death. It was thus a miracle that insulin treatment would rescue the lives of diabetics, and Banting and MacLeod were awarded the Nobel Prize in 1923 for their pioneering work in Toronto (1). As time went by, it became apparent that diabetic patients suffer from late complications such as neuropathy, retinopathy, vascular diseases and kidney failure. Such complications are now ascribed to inappropriate fluctuations in blood glucose levels as revealed in recent clinical trials (DCCT &UKPDS) (2-4). Insulin thus provides a treatment of diabetes - not a cure.

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Authors and Affiliations

  1. Hagedorn Research Institute, DK-2820, Gentofte, Denmark

    Ole D. Madsen Ph.D., Palle Serup Ph.D., Jan Jensen Ph.D., Helle V. Petersen Ph.D. & R. Scott Heller Ph.D.

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  1. Ole D. Madsen Ph.D.
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  2. Palle Serup Ph.D.
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  3. Jan Jensen Ph.D.
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  4. Helle V. Petersen Ph.D.
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Editors and Affiliations

  1. Laboratory of Molecular Endocrinology, Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA

    Joel F. Habener M.D.

  2. Department of Medicine, Clinical and Molecular Endocrinology, New York University Medical Center, New York, NY

    Mehboob A. Hussain M.D.

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Madsen, O.D., Serup, P., Jensen, J., Petersen, H.V., Heller, R.S. (2001). An Historical and Phylogenetic Perspective of Islet-Cell Development. In: Habener, J.F., Hussain, M.A. (eds) Molecular Basis of Pancreas Development and Function. Endocrine Updates, vol 11. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1669-9_1

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