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Human Circadian Physiology and Sleep-Wake Regulation

  • Chapter
Circadian Clocks

Part of the book series: Handbook of Behavioral Neurobiology ((HBNE,volume 12))

Abstract

Periodic daily cycles have been observed in a wide range of physiologic and behavioral variables in humans. These include cyclic variations in sleep propensity, neurobehavioral performance, motor performance, as well as thermoregulatory, endocrine, cardiac, gastrointestinal, pulmonary, renal, and neurologic functions, including sensory sensitivity. The rhythms of all of these variables exhibit a specific temporal relationship with each other and with the environmental light—dark cycle. The mechanisms underlying these rhythms, their temporal relationships, and their functional significance have been the subject of numerous investigations (Conroy & Mills, 1970).

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Authors and Affiliations

  1. Circadian, Neuroendocrine and Sleep Disorders Section, Division of Endocrinology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, 02115

    Charles A. Czeisler

  2. Institute of Pharmacology, University of Zürich, Zürich, CH-8057, Switzerland

    Derk-Jan Dijk

  3. Center for Chronobiology, University of Surrey, Guilford, GU27XH, UK

    Derk-Jan Dijk

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  1. Charles A. Czeisler
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  1. Northwestern University, Evanston, Illinois, USA

    Joseph S. Takahashi , Fred W. Turek  & Robert Y. Moore ,  & 

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Czeisler, C.A., Dijk, DJ. (2001). Human Circadian Physiology and Sleep-Wake Regulation. In: Takahashi, J.S., Turek, F.W., Moore, R.Y. (eds) Circadian Clocks. Handbook of Behavioral Neurobiology, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1201-1_21

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