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The Role of Metabolomics in Systems Biology

A New Vision for Drug Discovery and Development

  • Chapter
Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis

Abstract

The recent completion of major milestones of the Human Genome Project has demonstrated the impact of the “omics revolution” on modern research in the life sciences (International Human Genome Sequencing Consortium, 2001; Venter et al., 2001). In turn, the enormous degree of complexity inherent in genomic information has revealed the limitations of purely genomic investigation. Recent research has extended to the study of the proteome, defined as the total protein complement encoded for by a genome. The enormity of this effort becomes evident when it is considered that the estimated 30,000 – 40,000 genes in the human are predicted to yield as many as 1 million distinct proteins due to processes such as transcriptional splicing and post-translational modifications. As such, proteomic analysis has stimulated dramatic technological advances for protein quantification, characterization, and identification (Gygi et al., 1999; Geng et al., 2000; Regnier et al., 2000; Barnes and Clemmer, 2001; McLuckey et al., 2001; Valentine et al., 2001).

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Authors and Affiliations

  1. Beyond Genomics Inc., 40 Bear Hill Rd., Waltham, MA, 02451, USA

    Jan van der Greef, Eugene Davidov, Aram S. Adourian, Matej Oresic, Edward W. Marple & Stephen Naylor

  2. TNO Pharma, PO Box 2215 2031CE, Zernikedreff 9, 2333 CK, Leiden, Netherlands

    Jan van der Greef, Elwin Verheij & Jack Vogels

  3. Division of Analytical Sciences, Leiden University/Amsterdam Center for Drug Research, NL-2300 RA, Leiden, Netherlands

    Jan van der Greef & Rob van der Heijden

Authors
  1. Jan van der Greef
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  2. Eugene Davidov
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  3. Elwin Verheij
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  4. Jack Vogels
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  5. Rob van der Heijden
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  6. Aram S. Adourian
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  7. Matej Oresic
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  8. Edward W. Marple
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  9. Stephen Naylor
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Editor information

Editors and Affiliations

  1. Pharmacia Corporation, Chesterfield, MO, 63198, USA

    George G. Harrigan

  2. Department of Chemistry, UMIST, PO Box 88, Manchester, M60 1QD, UK

    Royston Goodacre

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van der Greef, J. et al. (2003). The Role of Metabolomics in Systems Biology. In: Harrigan, G.G., Goodacre, R. (eds) Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0333-0_10

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  • DOI: https://doi.org/10.1007/978-1-4615-0333-0_10

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