Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis

  • George G. Harrigan
  • Royston Goodacre

Table of contents

  1. Front Matter
    Pages i-xiv
  2. George G. Harrigan, Royston Goodacre
    Pages 1-8
  3. Seetharaman Vaidyanathan, Royston Goodacre
    Pages 9-38
  4. Julian L. Griffin, Elizabeth Sang
    Pages 39-68
  5. Alan P. Breau, Glenn H. Cantor
    Pages 69-82
  6. Yeun-Li Chung, Marion Stubbs, John R. Griffiths
    Pages 83-94
  7. Sarah Clarke, Royston Goodacre
    Pages 95-110
  8. David I. Ellis, George G. Harrigan, Royston Goodacre
    Pages 111-124
  9. László G. Boros, Marta Cascante, Wai-Nang Paul Lee
    Pages 141-169
  10. Jan van der Greef, Eugene Davidov, Elwin Verheij, Jack Vogels, Rob van der Heijden, Aram S. Adourian et al.
    Pages 171-198
  11. Jaideep Chaudhary, Tim Compton, Jeff A. Parrott
    Pages 217-238
  12. Royston Goodacre, Douglas B. Kell
    Pages 239-256
  13. Eberhard O. Voit, Jonas Almeida
    Pages 257-276
  14. Nigel Hardy, Helen Fuell
    Pages 277-291
  15. X. Jing Li, Olga Brazhnik, Aejaaz Kamal, Dianjing Guo, Christine Lee, Stefan Hoops et al.
    Pages 293-309
  16. Chris W. W. Beecher
    Pages 311-319
  17. Back Matter
    Pages 321-335

About this book

Introduction

It is evident that biochemical control is not strictly hierarchical and that intermediary metabolism can contribute to control of regulatory pathways. Metabolic studies are therefore increasingly important in gene function analyses, and an increased interest in metabolites as biomarkers for disease progression or response to therapeutic intervention is also evident in the pharmaceutical industry. This book offers guidelines to currently available technology and bioinformatics and database strategies now being developed. Evidence is presented that metabolic profiling is a valuable addition to genomics and proteomics strategies devoted to drug discovery and development, and that metabolic profiling offers numerous advantages.

Keywords

Proteomics biology metabolism nuclear magnetic resonance (NMR) spectroscopy

Editors and affiliations

  • George G. Harrigan
    • 1
  • Royston Goodacre
    • 2
  1. 1.Pharmacia CorporationChesterfieldUSA
  2. 2.Department of ChemistryUMISTManchesterUK

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-0333-0
  • Copyright Information Springer-Verlag US 2003
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-5025-5
  • Online ISBN 978-1-4615-0333-0
  • About this book