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TRIM Involvement in Transcriptional Regulation

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TRIM/RBCC Proteins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 770))

Abstract

Members of the tripartite motif (TRIM) protein family are found in all multicellular eukaryotes and function in a wide range of cellular processes such as cell cycle regulation, differentiation, development, oncogenesis and viral response. Over the past few years, several TRIM proteins have been reported to control gene expression through regulation of the transcriptional activity of numerous sequence-specific transcription factors. These proteins include the transcriptional intermediary factor 1 (TIF1) regulators, the promyelocytic leukemia tumor suppressor PML and the RET finger protein (RFP). In this chapter, we will consider the molecular interactions made by these TRIM proteins and will attempt to clarify some of the molecular mechanisms underlying their regulatory effect on transcription.

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Authors and Affiliations

  1. Department of Functional Genomics, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP/Collège de France, Illkirch, France

    Florence Cammas, Konstantin Khetchoumian, Pierre Chambon & Régine Losson

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  1. Florence Cammas
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  2. Konstantin Khetchoumian
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  3. Pierre Chambon
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  4. Régine Losson
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  1. Cluster in Biomedicine, CBM S.c.r.l., AREA Science Park, Trieste, Italy

    Germana Meroni Phd

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Cammas, F., Khetchoumian, K., Chambon, P., Losson, R. (2012). TRIM Involvement in Transcriptional Regulation. In: Meroni, G. (eds) TRIM/RBCC Proteins. Advances in Experimental Medicine and Biology, vol 770. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5398-7_5

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