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TRIM/RBCC Proteins

  • Book
  • © 2012

Overview

Editors:
  1. Germana Meroni

    1. Cluster in Biomedicine, CBM S.c.r.l., Trieste, Italy

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  • Gives an overview of state-of-the-art basic findings on the tripartite motif (TRIM, also known as RBCC) family members
  • Discusses physiological and pathological roles of the TRIM
  • Provides the foundation to contribute to foster novel discoveries in the rapidly evolving field of TRIM proteins biology

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 770)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xix
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  2. Genomics and Evolution of the TRIM Gene Family

    • Germana Meroni
    Pages 1-9

  3. The Tripartite Motif

    • Lucia Micale, Evelyne Chaignat, Carmela Fusco, Alexandre Reymond, Giuseppe Merla
    Pages 11-25

  4. Trim Proteins as Ring Finger E3 Ubiquitin Ligases

    • Kazuhiro Ikeda, Satoshi Inoue
    Pages 27-37

  5. PML Nuclear Bodies and Other Trim-Defined Subcellular Compartments

    • Elizabeth C. Batty, Kirsten Jensen, Paul S. Freemont
    Pages 39-58

  6. TRIM Involvement in Transcriptional Regulation

    • Florence Cammas, Konstantin Khetchoumian, Pierre Chambon, Régine Losson
    Pages 59-76

  7. TRIM Proteins in Cancer

    • Valeria Cambiaghi, Virginia Giuliani, Sara Lombardi, Cristiano Marinelli, Francesca Toffalorio, Pier Giuseppe Pelicci
    Pages 77-91

  8. TRIM Proteins and the Innate Immune Response to Viruses

    • Melvyn W. Yap, Jonathan P. Stoye
    Pages 93-104

  9. The Microtubule-Associated C-I Subfamily of TRIM Proteins and the Regulation of Polarized Cell Responses

    • Timothy C. Cox
    Pages 105-118

  10. MuRFs Specialized Members of the TRIM/RBCC Family with Roles in the Regulation of the Trophic State of Muscle and Its Metabolism

    • Olga Mayans, Siegfried Labeit
    Pages 119-129

  11. TRIM Proteins in Development

    • Francesca Petrera, Germana Meroni
    Pages 131-141

  12. Back Matter

    Pages 143-145
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Keywords

About this book

The genomic ‘golden age’ has delivered the sequence of numerous novel genes while leaving us with many unanswered questions about their function. This is particularly true for gene families as, often, members are annotated based on homology rather than function. The tripartite motif family belonged to this category, although, during the last few years, the field boosted an important wealth of biochemical, cellular and physiological breakthrough data. In the first part of this book, we attempt to offer an overview of state‑of‑the‑art basic findings on the tripartite motif (TRIM, also known as RBCC) family members and to deal in the second part with their relevant and growing physiological and pathological roles.

Editors and Affiliations

  • Cluster in Biomedicine, CBM S.c.r.l., Trieste, Italy

    Germana Meroni

About the editor

Germana Meroni is a graduate of the University of Milan, Italy. She was a post‑graduate fellow at the Department of Biotechnology of the San Raffaele Hospital in Milan, Italy, and then post‑doctoral fellow at the Department of Human and Molecular Genetics of Baylor College of Medicine, Houston, TX (USA). She established her research group at the Telethon Institute of Genetics and Medicine (TIGEM) in Naples and then moved as leader of the Functional Genomics Laboratory at the Cluster in Biomedicine within AREA Science Park in Trieste, Italy. Her main research interest is the genetics and biochemistry of the Tripartite Motif family in health and disease.

Bibliographic Information

  • Book Title: TRIM/RBCC Proteins

  • Editors: Germana Meroni

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4614-5398-7

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2012

  • Hardcover ISBN: 978-1-4614-5397-0Published: 04 December 2012

  • Softcover ISBN: 978-1-4939-4660-0Published: 22 October 2016

  • eBook ISBN: 978-1-4614-5398-7Published: 30 July 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIX, 145

  • Topics: Biomedicine general, Molecular Medicine

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