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TRIM Proteins in Development

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TRIM/RBCC Proteins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 770))

Abstract

TRIM proteins play important roles in several patho-physiological processes. Their common activity within the ubiquity lation pathway makes them amenable to a number of diverse biological roles. Many of the TRIM genes are highly and sometimes specifically expressed during embryogenesis, it is therefore not surprising that several of them might be involved in developmental processes. Here, we primarily discuss the developmental implications of two subgroups of TRIM proteins that conserved domain composition and functions from their invertebrate ancestors. The two groups are: the TRIM-NHL proteins implicated in miRNA processing regulation and the TRIM-FN3 proteins involved in ventral midline development.

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Authors and Affiliations

  1. Cluster in Biomedicine, CBM S.c.r.l, AREA Science Park, Trieste, Italy

    Francesca Petrera & Germana Meroni

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  1. Francesca Petrera
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  2. Germana Meroni
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  1. Cluster in Biomedicine, CBM S.c.r.l., AREA Science Park, Trieste, Italy

    Germana Meroni Phd

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Petrera, F., Meroni, G. (2012). TRIM Proteins in Development. In: Meroni, G. (eds) TRIM/RBCC Proteins. Advances in Experimental Medicine and Biology, vol 770. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5398-7_10

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