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Metastasis Suppressor Genes

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Experimental and Clinical Metastasis

Abstract

Below is a list of the most extensively studied MSGs, describing their initial characterization as well as what possible mechanism has been characterized for each .

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References

  • Bakalian S et al (2007) Expression of nm23-H1 in uveal melanoma. Melanoma Res 17(5):284–290

    Article  PubMed  CAS  Google Scholar 

  • Bandyopadhyay S et al (2003) The Drg-1 gene suppresses tumor metastasis in prostate cancer. Cancer Res 63(8):1731–1736

    PubMed  CAS  Google Scholar 

  • Bandyopadhyay S et al (2004) Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression. Oncogene 23(33):5675–5681

    Article  PubMed  CAS  Google Scholar 

  • Boissan M et al (2005) Increased lung metastasis in transgenic NM23-Null/SV40 mice with hepatocellular carcinoma. J Natl Cancer Inst 97(11):836–845

    Article  PubMed  CAS  Google Scholar 

  • Cacace AM et al (1999) Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression. Mol Cell Biol 19(1):229–240

    PubMed  CAS  Google Scholar 

  • Caligo MA et al (1994) A low NM23.H1 gene expression identifying high malignancy human melanomas. Melanoma Res 4(3):179–184

    Article  PubMed  CAS  Google Scholar 

  • Chekmareva MA et al (1998) Chromosome 17-mediated dormancy of AT6.1 prostate cancer micrometastases. Cancer Res 58(21):4963–4969

    PubMed  CAS  Google Scholar 

  • Dhar DK et al (2004) Downregulation of KiSS-1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma. Int J Cancer 111(6):868–872

    Article  PubMed  CAS  Google Scholar 

  • Dong JT et al (1995) KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. Science 268(5212):884–886

    Article  PubMed  CAS  Google Scholar 

  • Ferrari D et al (2007) Dermatopathological indicators of poor melanoma prognosis are significantly inversely correlated with the expression of NM23 protein in primary cutaneous melanoma. J Cutan Pathol 34(9):705–712

    Article  PubMed  Google Scholar 

  • Freije JM et al (1997) Site-directed mutation of Nm23-H1. Mutations lacking motility suppressive capacity upon transfection are deficient in histidine-dependent protein phosphotransferase pathways in vitro. J Biol Chem 272(9):5525–5532

    Article  PubMed  CAS  Google Scholar 

  • Fu Z et al (2003) Effects of raf kinase inhibitor protein expression on suppression of prostate cancer metastasis. J Natl Cancer Inst 95(12):878–889

    Article  PubMed  CAS  Google Scholar 

  • Fu Z et al (2006) Metastasis suppressor gene Raf kinase inhibitor protein (RKIP) is a novel prognostic marker in prostate cancer. Prostate 66(3):248–256

    Article  PubMed  CAS  Google Scholar 

  • Goldberg SF et al (1999) Metastasis-suppressed C8161 melanoma cells arrest in lung but fail to proliferate. Clin Exp Metastasis 17(7):601–607

    Article  PubMed  CAS  Google Scholar 

  • Guan RJ et al (2000) Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancer. Cancer Res 60(3):749–755

    PubMed  CAS  Google Scholar 

  • Hartsough MT, Steeg PS (2000) Nm23/nucleoside diphosphate kinase in human cancers. J Bioenerg Biomembr 32(3):301–308

    Article  PubMed  CAS  Google Scholar 

  • Hartsough MT et al (2002) Nm23-H1 metastasis suppressor phosphorylation of kinase suppressor of Ras via a histidine protein kinase pathway. J Biol Chem 277(35):32389–32399

    Article  PubMed  CAS  Google Scholar 

  • Heimann R, Ferguson DJ, Hellman S (1998) The relationship between nm23, angiogenesis, and the metastatic proclivity of node-negative breast cancer. Cancer Res 58(13):2766–2771

    PubMed  CAS  Google Scholar 

  • Ichikawa T et al (1992) Localization of metastasis suppressor gene(s) for prostatic cancer to the short arm of human chromosome 11. Cancer Res 52(12):3486–3490

    PubMed  CAS  Google Scholar 

  • Ikeguchi M, Yamaguchi K, Kaibara N (2004) Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma. Clin Cancer Res 10(4):1379–1383

    Article  PubMed  CAS  Google Scholar 

  • Kim HL et al (2001) Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers. Cancer Res 61(7):2833–2837

    PubMed  CAS  Google Scholar 

  • Klysik J et al (2008) Signaling crossroads: the function of Raf kinase inhibitory protein in cancer, the central nervous system and reproduction. Cell Signal 20(1):1–9

    Article  PubMed  CAS  Google Scholar 

  • Kovacevic Z, Richardson DR (2006) The metastasis suppressor, Ndrg-1: a new ally in the fight against cancer. Carcinogenesis 27(12):2355–2366

    Article  PubMed  CAS  Google Scholar 

  • Lacombe ML et al (2000) The human Nm23/nucleoside diphosphate kinases. J Bioenerg Biomembr 32(3):247–258

    Article  PubMed  CAS  Google Scholar 

  • Lee JH, Welch DR (1997) Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1. Cancer Res 57(12):2384–2387

    PubMed  CAS  Google Scholar 

  • Lee JH et al (1996) KiSS-1, a novel human malignant melanoma metastasis-suppressor gene. J Natl Cancer Inst 88(23):1731–1737

    Article  PubMed  CAS  Google Scholar 

  • Liu WM, Zhang XA (2006) KAI1/CD82, a tumor metastasis suppressor. Cancer Lett 240(2):183–194

    Article  PubMed  CAS  Google Scholar 

  • Liu YN et al (2005) Regulatory mechanisms controlling human E-cadherin gene expression. Oncogene 24(56):8277–8290

    Article  PubMed  CAS  Google Scholar 

  • Malik FA, Sanders AJ, Jiang WG (2009) KAI-1/CD82, the molecule and clinical implication in cancer and cancer metastasis. Histol Histopathol 24(4):519–30

    PubMed  CAS  Google Scholar 

  • Meehan WJ, Welch DR (2003) Breast cancer metastasis suppressor 1: update. Clin Exp Metastasis 20(1):45–50

    Article  PubMed  CAS  Google Scholar 

  • Metge BJ et al (2010) Elevated Osteopontin Levels in Metastatic Melanoma Correlate with Epigenetic Silencing of Breast Cancer Metastasis Suppressor 1. Oncology 78(1):75–86

    Article  PubMed  CAS  Google Scholar 

  • Miele ME et al (1996) Metastasis suppressed, but tumorigenicity and local invasiveness unaffected, in the human melanoma cell line MelJuSo after introduction of human chromosomes 1 or 6. Mol Carcinog 15(4):284–299

    Article  PubMed  CAS  Google Scholar 

  • Morrison DK (2001) KSR: a MAPK scaffold of the Ras pathway? J Cell Sci 114(Pt 9):1609–1612

    PubMed  CAS  Google Scholar 

  • Nash KT, Welch DR (2006) The KISS1 metastasis suppressor: mechanistic insights and clinical utility. Front Biosci 11:647–659

    Article  PubMed  CAS  Google Scholar 

  • Nash KT et al (2007) Requirement of KISS1 secretion for multiple organ metastasis suppression and maintenance of tumor dormancy. J Natl Cancer Inst 99(4):309–321

    Article  PubMed  CAS  Google Scholar 

  • Ohtaki T et al (2001) Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature 411(6837):613–617

    Article  PubMed  CAS  Google Scholar 

  • Orsini MJ et al (2007) Metastin (KiSS-1) mimetics identified from peptide structure-activity relationship-derived pharmacophores and directed small molecule database screening. J Med Chem 50(3):462–471

    Article  PubMed  CAS  Google Scholar 

  • Pacifico MD et al (2005) nm23 as a prognostic marker in primary cutaneous melanoma: evaluation using tissue microarray in a patient group with long-term follow-up. Melanoma Res 15(5):435–440

    Article  PubMed  CAS  Google Scholar 

  • Sanchez-Carbayo M, Capodieci P, Cordon-Cardo C (2003) Tumor suppressor role of KiSS-1 in bladder cancer: loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome. Am J Pathol 162(2):609–617

    Article  PubMed  CAS  Google Scholar 

  • Seraj MJ et al (2000a) The relationship of BRMS1 and RhoGDI2 gene expression to metastatic potential in lineage related human bladder cancer cell lines. Clin Exp Metastasis 18(6):519–525

    Article  CAS  Google Scholar 

  • Seraj MJ et al (2000b) Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13. Cancer Res 60(11):2764–2769

    CAS  Google Scholar 

  • Shirasaki F et al (2001) Loss of expression of the metastasis suppressor gene KiSS1 during melanoma progression and its association with LOH of chromosome 6q16.3-q23. Cancer Res 61(20):7422–7425

    PubMed  CAS  Google Scholar 

  • Stark AM et al (2005) Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases. J Cancer Res Clin Oncol 131(3):191–198

    Article  PubMed  CAS  Google Scholar 

  • Steeg PS (2003) Metastasis suppressors alter the signal transduction of cancer cells. Nat Rev Cancer 3(1):55–63

    Article  PubMed  CAS  Google Scholar 

  • Steeg PS (2004) Perspectives on classic article: metastasis suppressor genes. J Natl Cancer Inst 96(6):E4

    Google Scholar 

  • Steeg PS, Theodorescu D (2008) Metastasis: a therapeutic target for cancer. Nat Clin Pract Oncol 5(4):206–219

    Article  PubMed  CAS  Google Scholar 

  • Theodorescu D et al (2004) Reduced expression of metastasis suppressor RhoGDI2 is associated with decreased survival for patients with bladder cancer. Clin Cancer Res 10(11):3800–3806

    Article  PubMed  CAS  Google Scholar 

  • Titus B et al (2005) Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2. Cancer Res 65(16):7320–7327

    Article  PubMed  CAS  Google Scholar 

  • van Belzen N et al (1997) A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms. Lab Invest 77(1):85–92

    PubMed  CAS  Google Scholar 

  • Vander Griend DJ et al (2005) Suppression of metastatic colonization by the context-dependent activation of the c-Jun NH2-terminal kinase kinases JNKK1/MKK4 and MKK7. Cancer Res 65(23):10984–10991

    Article  PubMed  CAS  Google Scholar 

  • Volle DJ et al (1999) Phosphorylation of the kinase suppressor of ras by associated kinases. Biochemistry 38(16):5130–5137

    Article  PubMed  CAS  Google Scholar 

  • Wagner PD, Steeg PS, Vu ND (1997) Two-component kinase-like activity of nm23 correlates with its motility-suppressing activity. Proc Natl Acad Sci U S A 94(17):9000–9005

    Article  PubMed  CAS  Google Scholar 

  • Whitmarsh AJ, Davis RJ (2007) Role of mitogen-activated protein kinase kinase 4 in cancer. Oncogene 26(22):3172–3184

    Article  PubMed  CAS  Google Scholar 

  • Wu Y et al (2007) Neuromedin U is regulated by the metastasis suppressor RhoGDI2 and is a novel promoter of tumor formation, lung metastasis and cancer cachexia. Oncogene 26(5):765–773

    Article  PubMed  CAS  Google Scholar 

  • Yamada SD et al (2002) Mitogen-activated protein kinase kinase 4 (MKK4) acts as a metastasis suppressor gene in human ovarian carcinoma. Cancer Res 62(22):6717–6723

    PubMed  CAS  Google Scholar 

  • Yoshida BA et al (1999) Mitogen-activated protein kinase kinase 4/stress-activated protein/Erk kinase 1 (MKK4/SEK1), a prostate cancer metastasis suppressor gene encoded by human chromosome 17. Cancer Res 59(21):5483–5487

    PubMed  CAS  Google Scholar 

  • Yoshida S et al (2001) The c-Jun NH2-terminal kinase3 (JNK3) gene: genomic structure, chromosomal assignment, and loss of expression in brain tumors. J Hum Genet 46(4):182–187

    Article  PubMed  CAS  Google Scholar 

  • Zhu S et al (2005) A chemical inhibitor reveals the role of Raf kinase inhibitor protein in cell migration. Chem Biol 12(9):981–991

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Jean-Claude Marshall MSc., PhD. .

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Marshall, JC., Bakalian, S., Maria de Oliveira Martins, C. (2013). Metastasis Suppressor Genes. In: Burnier, J., Burnier, Jr., M. (eds) Experimental and Clinical Metastasis. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3685-0_4

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