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The Role of Adams in Notch Signaling

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Notch Signaling in Embryology and Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 727))

Abstract

Regulated intramembrane proteolysis (RIP) is a highly conserved signaling paradigm whereby membrane-bound signaling proteins are cleaved in their transmembrane region and then released into the cytoplasm to act as signaling molecules. In most if not all cases intramembrane cleavage is preceded and regulated by a membrane proximal cleavage step called ‘ectodomain shedding’. Here we will review the role of ectodomain shedding in RIP of the NOTCH signaling pathway, a highly conserved cell-cell communication pathway that mediates cell fate decisions during development and in adult tissues.

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Authors and Affiliations

  1. Maastricht Radiation Oncology (MAASTRO) and School for Oncology and Developmental Biology (GROW), University of Maastricht, Maastricht, The Netherlands

    Arjan J. Groot & Marc A. Vooijs

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  1. Arjan J. Groot
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  2. Marc A. Vooijs
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Correspondence to Marc A. Vooijs .

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  1. Department of Dermatology, The Saarland University Hospital, Homburg, Germany

    Jörg Reichrath

  2. Department of Internal Medicine I, The Saarland University Hospital, Homburg, Germany

    Sandra Reichrath

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Groot, A.J., Vooijs, M.A. (2012). The Role of Adams in Notch Signaling. In: Reichrath, J., Reichrath, S. (eds) Notch Signaling in Embryology and Cancer. Advances in Experimental Medicine and Biology, vol 727. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0899-4_2

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