Abstract
The terms “miliary tuberculosis” and “lym-phohematogenous dissemination of tuberculosis” are used commonly, but sometimes with less than precise meaning. In this chapter, miliary tuberculosis defines the presence of innumerable, tiny, discrete tuberculous lesions in the lungs and other organs owing to the seeding of these tissues by blood-borne tubercle bacilli. The word “miliary” was used originally to denote the small size of such lesions, generally less than 2 mm in diameter, or approximately the size of millet seeds. “Hematogenous dissemination” reflects bacillemia due to tubercle bacilli regardless of the mode of entry into the bloodstream. “Lymphohematogenous dissemination” designates the entry of tubercle bacilli, usually from a parenchymal pulmonary focus, into the lymphatics, lymph nodes, and ducts, with ultimate drainage into the bloodstream producing bacillemia.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
American Thoracic Society: Mycobacteriosis and the Acquired Immunodeficiency Syndrome. Am Rev Resp Dis 1987;136:492–496.
Amos A, Denning D, et al: Computed tomography of chest in diagnosis of miliary tuberculosis. Lancet 1987;i:1269–1270.
Barnes PF, Bloch AB, et al: Current concepts: Tuberculosis in patients with Human Immunodeficiency Virus Infection. NEJM 1991; 324:1644–1650.
Bobrowitz ID: Active tuberculosis undiagnosed until autopsy. Am J Med 1982;72:650–658.
Bowry S, Chan CH, et al: Hepatic involvement in pulmonary tuberculosis: histologic and functional characteristics. Am Rev Resp Dis 1970; 101:941–948.
Burk JR, Viroslov J, Bynum LJ: Miliary tuberculosis diagnosed by fiberoptic bronchoscopy and transbronchial biopsy. Tubercle 1978;59: 107–109.
Cameron SJ: Tuberculosis and the blood—a special relationship? Tubercle 1974;55:55–72.
Centers for Disease Control: Tuberculosis and human immunodeficiency virus infection. Recommendations of the Advisory Committee for the Elimination of Tuberculosis (ACET). MMWR 1989;38, No. 17:326–238.
Centers for Disease Control: Tuberculosis and human immunodeficiency virus infection. Recommendations of the Advisory Committee for the Elimination of Tuberculosis (ACET). MMWR 1989;38, No. 17: 243–250.
Chang DK, Hubbard WW: Hyponatremia in untreated active pulmonary tuberculosis. Am Rev Resp Dis 1969;99:595–597.
Coburn RJ, England JM, et al: Tuberculosis and blood disorders. Br J Hem 1973;25:793–799.
Cucin RL, Coleman M, et al: The diagnosis of miliary tuberculosis: utility of peripheral blood abnormalities, bone marrow and liver biopsy. J Chronic Dis 1973;26:355–361.
Debre R: Miliary tuberculosis in children. Lancet 1952;2:545–549.
Ellman L: Bone marrow biopsy in the evaluation of lymphoma, carcinoma and granulomatous disorders. Am J Med 1976;60:1–7.
Freeman RM, Newhouse CE, Rawton RL: Absence of tuberculosis in dialyzed patients. JAMA 1975;233:1356.
Gelb AF, Leffler C, et al: Miliary tuberculosis. Am Rev Resp Dis 1973;108:1327–1333.
Glasser RM, Walker RI, Henon JC: The significance of hematogenous abnormalities in patients with tuberculosis. Arch Intern Med 1970;125:691–695.
Grieco MH, Chmel H: Acute disseminated tuberculosis as a diagnostic problem: a clinical study based on twenty-eight cases. Am Rev Resp Dis 1974;109:554–560.
Guckian JC, Perry JE: Granulomatous hepatitis: an analysis of 63 cases and review of the literature. Ann Intern Med 1966;65:1081–1099.
Gupta RC, Laveogood R, Smith JP: Miliary tuberculosis due to extravesical basillus Calmette-Guerin therapy. Chest 1988;94:1296–1298.
Hawkins CC, Gold JWH, Whimbey E: Mycobacterium avium complex infections in patients with the acquired immunodeficiency syndrome. Ann Intern Med 1986;105:184–188.
Hill AR., Premkumar S, et al.: Disseminated tuberculosis in the acquired immunodeficiency syndrome era. Am Rev Resp Dis 1991; 144:1164–1170.
Hunt BJ, Andrews V Pettengale RW: The significance of pancytopenia in miliary tuberculosis. Postgr ad. Med J 1987;63:801–804.
Illingsworth RS, Wright T: Tubercles of the choroid. Br Med J 1948;2:365–68.
Jacques J, Sloan JM: The changing pattern of miliary tuberculosis. Thorax 1970;25:237–240.
Kaplan MH, Armstrong D, Rosen P: Tuberculosis complicating neoplastic disease: a review of 201 cases. Cancer 1973;33:850–858.
Lincoln EM: Hematogenous tuberculosis in children. Am J Dis Child 1935;50:84–103.
Lincoln EM, Sewell EM: Tuberculosis in Children. New York, McGraw-Hill, 1963.
Lundin AP, Adler AJ, Berdyne GM, et al: Tuberculosis in patients undergoing maintenance hemodialysis. Am J Med 1979;67:597–602.
McClement JH, Renzetti AD Jr, et al: Cardiopulmonary functions in hematogenous pulmonary tuberculosis in patients receiving streptomycin. An Rev Tuberc 1951;64:583–601.
Maartens G., Wilcox PA, Benatar SR.: Miliary tuberculosis: rapid diagnosis, hematologic abnormalities, and outcome in 109 treated adults. Am J Med 1990;89:291–296.
Massaro D, Katz S, Sachs M: Choroidal tubercles: a clue to hematogenous tuberculosis. Ann Intern Med 1964;60:231–241.
Modilevsky T, Sattler FR, Barnes PF: Mycobacterial disease in patients with human immunodeficiency virus infection. Ann Intern Med 1989;149:2201–2205.
Munt PW: Miliary tuberculosis in the chemotherapy era: with a clinical review in 69 American adults. Medicine 1972;51:139–155.
Murray HW, Tuazon CU, et al: The adult respiratory distress syndrome associated with miliary tuberculosis. Chest 1978;73:37–42.
Narang RK, Kumar S, Grupta A: Pneumothorax and pneumo-mediastinum complicating acute miliary tuberculosis. Tubercle 1977;58:79–82.
Pitchenik AE, Rubenson HA: The radiographic appearance of tuberculosis in patients with the acquired immune deficiency syndrome (AIDS) and Pre-AIDS. Am Rev Resp Dis 1985;131:393–396.
Pradhan RP, Katz LA, Nidus BD, et al: Tuberculosis in dialysis. JAMA 1974;229:798–800.
Proudfoot AT, Akhtar AJ, et al: Miliary tuberculosis in adults. Br Med J 1969;2:273–276.
Prout S, Benatar R: Disseminated tuberculosis: a study of 62 cases. S Afr Med J 1980;58:835–842.
Rich AR: The Pathogenesis of Tuberculosis, 2 ed. Springfield, Ill., Charles C. Thomas, 1951.
Rosenthal T, Pitlik S, Michaeli D: Fatal undiagnosed tuberculosis in hospitalized patients. J Infect Dis 1975;131(suppl):551–556.
Sahn SA, Levin DC: Diagnosis of miliary tuberculosis by transbronchial biopsy. Am Med J 1975;2:667–668.
Sahn SA, Neff TA: Miliary tuberculosis. Am J Med 1974;56:495–505.
Scife M, Kessler BJ, et al: A clinical, functional and needle biopsy study of the liver in pulmonary tuberculosis. Am Rev Tuber 1951;63:202–209.
Sesaki S, Takashi A, et al: Ten years’ survey of dialysis-associated tuberculosis. Nephron 1979; 24:141–145.
Skouteles A, Melekos MD, Bassaris HJ: Miliary tuberculosis secondary to transurethral Bacillus Calmette-Guerin administration for superficial transitional cell carcinoma of the bladder. J NCI 1990;82:1219–1220.
Slavin RE, Walsh TJ, Pollack AD: Late generalized tuberculosis: a clinical pathologic analysis and comparison of 100 cases in the pre-antibiotic and antibiotic eras. Medicine 1980;59:352–366.
Small PM, Schecter G, et al: Treatment of tuberculosis in patients with advanced human immunodeficiency virus infection. N Engl J Med 1991;324:289–294.
Stenius-Aarnala B, Tukainen P: Miliary tuberculosis. Acta Med Scand 1979;206:412–422.
Tongnian S, Jiayu Y, Liye Z, et al: Chemotherapy and its complications with corticosteroids in acute miliary tuberculosis in adolescents and adults. Chin Med J 1981;94:309–314.
Yu YL, Chow MJ, Humphries MJ, et al: Cryptic miliary tuberculosis. Quat J Med 1986; 59:421–428.
Williams MH, Jr, Yoo OH, Kane C: Pulmonary function in miliary tuberculosis. Am Rev Resp Dis 1973;107:858–860.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer-Verlag New York, Inc.
About this chapter
Cite this chapter
Harris, H.W., Menitove, S. (1994). Miliary Tuberculosis. In: Schlossberg, D. (eds) Tuberculosis. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8321-5_21
Download citation
DOI: https://doi.org/10.1007/978-1-4613-8321-5_21
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4613-8323-9
Online ISBN: 978-1-4613-8321-5
eBook Packages: Springer Book Archive