Abstract
The first two amino acids to be isolated from protein hydrolysates were glycine and leucine, both by Braconnot and both in 1820.(1) Of these two, leucine was isolated from wool, which can thus lay claim to a long history in protein chemistry. Other early investigators attempted to use the techniques of elementary analysis to derive an empirical formula for wool, but it was speedily recognized that the molecule was far too complex to be handled in this way. With the establishment in 1901 by Fischer of the polypeptide theory of protein structure, it was realized that the first step in the elucidation of the chemical structure of proteins was the determination of the relative amounts of the differing amino acids in a hydrolysate of the protein, and interest in elementary analysis became restricted to nitrogen and sulfur estimations, which permitted estimates of the total recovery of amino acids and sulfur-containing amino acids to be made.
All the facts of Nature are so indissolubly linked together that it is only by first grasping the simpler ones that we can even begin to understand the superb craftsmanship that finds expression in the structure of living things.
W. T. Astbury
Fundamentals of Fibre Structure
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Lindley, H. (1977). The Chemical Composition and Structure of Wool. In: Asquith, R.S. (eds) Chemistry of Natural Protein Fibers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4109-3_4
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